|
|
 Previous Article | Table of Contents | Next Article 
Platelet adhesion to collagen type IV under flow conditions
G Henrita van Zanten, EU Saelman, KM Schut-Hese, YP Wu, PJ Slootweg, HK Nieuwenhuis, PG de Groot and JJ Sixma
Department of Haematology, University Hospital Utrecht, The Netherlands.
Collagen type IV is a sheet-forming collagen and a major constituent of the
vessel wall. To find out which conditions are important for platelet
adhesion to collagen type IV, we performed perfusion studies with
anticoagulated blood in parallel plate perfusion chambers. The role of
divalent cations was investigated by using plasmas with variable
concentrations of Mg2+ and Ca2+ ions. When Mg2+ concentration was decreased
from 2.00 mmol/L to 0.25 mmol/L at a fixed Ca2+ concentration of 1.25
mmol/L, platelet coverage on the collagen type IV surface decreased from
22.8% +/- 1.8% (n = 4) to 4.6% +/- 0.6% (n = 4) at a shear rate of 1,600
s-1. Also, platelet aggregate formation on collagen type IV was strongly
impaired. A monoclonal antibody against the glycoprotein (Gp) Ib receptor
and von Willebrand factor (vWF)- depleted plasma reduced the platelet
coverage to collagen type IV to, respectively, 10% and 45% of the control
value. Electron microscopy showed that vWF was only present between
platelets and between the platelet and the collagen type IV surface, but
did not bind elsewhere to collagen type IV. These data indicate that
collagen type IV is a reactive collagen for platelets. Differences in
physiologic plasma magnesium concentrations may in part explain the
differences in platelet reactivity to collagen type IV between individuals,
and perhaps contribute to differences in the risk for thrombosis.
Volume 88,
Issue 10,
pp. 3862-3871,
11/15/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Drewniak, J.-J. Boelens, H. Vrielink, A. T.J. Tool, M. C.A. Bruin, M. van den Heuvel-Eibrink, L. Ball, M. D. van de Wetering, D. Roos, and T. W. Kuijpers
Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes
Haematologica,
July 1, 2008;
93(7):
1058 - 1067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, V. M. Kamp, C. W. van Aalst, L. P. Verhagen, M. E. Sanders, K. A. Reedquist, M. Buitenhuis, and L. Koenderman
Homeostatic Intracellular-Free Ca2+ Is Permissive for Rap1-Mediated Constitutive Activation of {alpha}4 Integrins on Eosinophils
J. Immunol.,
April 15, 2008;
180(8):
5512 - 5519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. d. C. Martins, J. M. van Gils, A. Mol, P. L. Hordijk, and J. J. Zwaginga
Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of {beta}1 and {beta}2 integrins
J. Leukoc. Biol.,
March 1, 2006;
79(3):
499 - 507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, J. Alblas, C. W. van Aalst, J. J. Zwaginga, and L. Koenderman
Differences in Potency of CXC Chemokine Ligand 8-, CC Chemokine Ligand 11-, and C5a-Induced Modulation of Integrin Function on Human Eosinophils
J. Immunol.,
November 1, 2005;
175(9):
6092 - 6099.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. P. E. M. Spijkers, P. da Costa Martins, E. Westein, C. G. Gahmberg, J. J. Zwaginga, and P. J. Lenting
LDL-receptor-related protein regulates {beta}2-integrin-mediated leukocyte adhesion
Blood,
January 1, 2005;
105(1):
170 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Ellerbroek, D. J. Lefeber, R. van Veghel, J. Scharringa, E. Brouwer, G. J. Gerwig, G. Janbon, A. I. M. Hoepelman, and F. E. J. Coenjaerts
O-Acetylation of Cryptococcal Capsular Glucuronoxylomannan Is Essential for Interference with Neutrophil Migration
J. Immunol.,
December 15, 2004;
173(12):
7513 - 7520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. da Costa Martins, N. van den Berk, L. H. Ulfman, L. Koenderman, P.L. Hordijk, and J.J. Zwaginga
Platelet-Monocyte Complexes Support Monocyte Adhesion to Endothelium by Enhancing Secondary Tethering and Cluster Formation
Arterioscler Thromb Vasc Biol,
January 1, 2004;
24(1):
193 - 199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Polanowska-Grabowska, J. M. Gibbins, and A. R.L. Gear
Platelet Adhesion to Collagen and Collagen-Related Peptide Under Flow: Roles of the {alpha}2{beta}1 Integrin, GPVI, and Src Tyrosine Kinases
Arterioscler Thromb Vasc Biol,
October 1, 2003;
23(10):
1934 - 1940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. C. H. Lutters, R. H. W. M. Derksen, W. L. Tekelenburg, P. J. Lenting, J. Arnout, and P. G. de Groot
Dimers of {beta}2-Glycoprotein I Increase Platelet Deposition to Collagen via Interaction with Phospholipids and the Apolipoprotein E Receptor 2'
J. Biol. Chem.,
September 5, 2003;
278(36):
33831 - 33838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, D. P. H. Joosten, C. W. van Aalst, J.-W. J. Lammers, E. A. van de Graaf, L. Koenderman, and J. J. Zwaginga
Platelets Promote Eosinophil Adhesion of Patients with Asthma to Endothelium under Flow Conditions
Am. J. Respir. Cell Mol. Biol.,
April 1, 2003;
28(4):
512 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. MAZZUCATO, M. R. COZZI, P. PRADELLA, D. PERISSINOTTO, A. MALMSTROM, M. MORGELIN, P. SPESSOTTO, A. COLOMBATTI, L. DE MARCO, and R. PERRIS
Vascular PG-M/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation
FASEB J,
December 1, 2002;
16(14):
1903 - 1916.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Windecker, I. Mayer, G. De Pasquale, W. Maier, O. Dirsch, P. De Groot, Y.-P. Wu, G. Noll, B. Leskosek, B. Meier, et al.
Stent Coating With Titanium-Nitride-Oxide for Reduction of Neointimal Hyperplasia
Circulation,
August 21, 2001;
104(8):
928 - 933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, D. P. H. Joosten, J. A. M. van der Linden, J.-W. J. Lammers, J. J. Zwaginga, and L. Koenderman
IL-8 Induces a Transient Arrest of Rolling Eosinophils on Human Endothelial Cells
J. Immunol.,
January 1, 2001;
166(1):
588 - 595.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Roest, J. J. Sixma, Y.-P. Wu, M. J. W. Ijsseldijk, M. Tempelman, P. J. Slootweg, P. G. de Groot, and G. H. van Zanten
Platelet adhesion to collagen in healthy volunteers is influenced by variation of both alpha 2beta 1 density and von Willebrand factor
Blood,
August 15, 2000;
96(4):
1433 - 1437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-P. Wu, T. Vink, M. Schiphorst, G. H. van Zanten, M. J. W. IJsseldijk, P. G. de Groot, and J. J. Sixma
Platelet Thrombus Formation on Collagen at High Shear Rates Is Mediated by von Willebrand Factor-Glycoprotein Ib Interaction and Inhibited by von Willebrand Factor-Glycoprotein IIb/IIIa Interaction
Arterioscler Thromb Vasc Biol,
June 1, 2000;
20(6):
1661 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, P. H. M. Kuijper, J. A. M. van der Linden, J.-W. J. Lammers, J. J. Zwaginga, and L. Koenderman
Characterization of Eosinophil Adhesion to TNF-{alpha}-Activated Endothelium Under Flow Conditions: {alpha}4 Integrins Mediate Initial Attachment, and E-Selectin Mediates Rolling
J. Immunol.,
July 1, 1999;
163(1):
343 - 350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mazzucato, P. Spessotto, A. Masotti, L. De Appollonia, M. R. Cozzi, A. Yoshioka, R. Perris, A. Colombatti, and L. De Marco
Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow
J. Biol. Chem.,
January 29, 1999;
274(5):
3033 - 3041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Verkleij, L. F. Morton, C. G. Knight, P. G. de Groot, M. J. Barnes, and J. J. Sixma
Simple Collagen-Like Peptides Support Platelet Adhesion Under Static But Not Under Flow Conditions: Interaction Via alpha 2beta 1 and von Willebrand Factor With Specific Sequences in Native Collagen Is a Requirement to Resist Shear Forces
Blood,
May 15, 1998;
91(10):
3808 - 3816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. van Zanten, H. F.G. Heijnen, Y. Wu, K. M. Schut-Hese, P. J. Slootweg, P. G. de Groot, J. J. Sixma, and R. Nieuwland
A Fifty Percent Reduction of Platelet Surface Glycoprotein Ib Does Not Affect Platelet Adhesion Under Flow Conditions
Blood,
April 1, 1998;
91(7):
2353 - 2359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lankhof, C. Damas, M. E. Schiphorst, M. J.W. IJsseldijk, M. Bracke, J. J. Sixma, T. Vink, and P. G. de Groot
Functional Studies on Platelet Adhesion With Recombinant von Willebrand Factor Type 2B Mutants R543Q and R543W Under Conditions of Flow
Blood,
April 15, 1997;
89(8):
2766 - 2772.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. C. H. Lutters, J. C. M. Meijers, R. H. W. M. Derksen, J. Arnout, and P. G. de Groot
Dimers of beta 2-Glycoprotein I Mimic the in Vitro Effects of beta 2-Glycoprotein I-Anti-beta 2-glycoprotein I Antibody Complexes
J. Biol. Chem.,
January 26, 2001;
276(5):
3060 - 3067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
