|
|
 Previous Article | Table of Contents | Next Article 
Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of
cytotoxic gamma delta T-cell origin
CB Cooke, L Krenacs, M Stetler-Stevenson, TC Greiner, M Raffeld, DW Kingma, L Abruzzo, C Frantz, M Kaviani and ES Jaffe
Hematopathology Section, National Cancer Institute, National Institutes of
Health, Bethesda, MD 20892-1500, USA.
We identified eight cases of T-cell lymphoma with evidence of a gamma delta
phenotype over a 13-year period. Seven of these cases conformed to a
distinct clinicopathologic entity of hepatosplenic gamma delta T- cell
lymphoma. Nearly all of these patients were young adult males (five of
seven), with a median age at presentation of 20 years. They presented with
marked hepatosplenomegaly, without lymphadenopathy or significant
peripheral blood lymphocytosis. Thrombocytopenia was seen in all patients,
and five of seven were mildly anemic. The clinical course was aggressive,
and despite multiagent chemotherapy, the median survival duration was less
than 1 year. The morphologic findings were uniform; a monomorphic
population of medium-sized lymphoid cells with moderately clumped chromatin
and a rim of pale cytoplasm infiltrated the sinusoids of the spleen, liver,
and bone marrow. The cells had a characteristic immunophenotype: CD2+,
CD3+, CD4-, CD5-, CD7+, CD16+, CD57-, CD25-, T-cell receptor (TCR)delta +,
beta F1-. CD8 was positive in four of seven cases tested, and CD56 was
positive in five of six. All cases expressed the cytotoxic
granule-associated protein, TIA1, but perforin was detected in only one
case. All cases with assessable DNA had a TCR gamma gene rearrangement, and
lacked Epstein-Barr virus sequences. Isochromosome 7q was identified in two
cases with cytogenetic information. The one case of cutaneous gamma delta
T-cell lymphoma differed in its clinical manifestations, histologic
appearance, and immunophenotype. We conclude that hepatosplenic gamma delta
T-cell lymphoma is a distinct clinicopathologic entity derived from
cytotoxic gamma delta T cells, and should be distinguished from other
lymphomas of T-cell and natural-killer cell (NK)-like T-cell derivation.
Volume 88,
Issue 11,
pp. 4265-4274,
12/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. S. Falchook, F. Vega, N. H. Dang, F. Samaniego, M. A. Rodriguez, R. E. Champlin, C. Hosing, S. Verstovsek, and B. Pro
Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment
Ann. Onc.,
June 1, 2009;
20(6):
1080 - 1085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Abramson, M. Chatterji, and A. Rahemtullah
Case 39-2008 -- A 51-Year-Old Woman with Splenomegaly and Anemia
N. Engl. J. Med.,
December 18, 2008;
359(25):
2707 - 2718.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Abramson, C. N. Kotton, N. Elias, D. V. Sahani, and R. P. Hasserjian
Case 8-2008 -- A 33-Year-Old Man with Fever, Abdominal Pain, and Pancytopenia after Renal Transplantation
N. Engl. J. Med.,
March 13, 2008;
358(11):
1176 - 1187.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Jaffe
Pathobiology of Peripheral T-cell Lymphomas
Hematology,
January 1, 2006;
2006(1):
317 - 322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nagato, H. Kobayashi, K. Kishibe, M. Takahara, T. Ogino, H. Ishii, K. Oikawa, N. Aoki, K. Sato, S. Kimura, et al.
Expression of Interleukin-9 in Nasal Natural Killer/T-Cell Lymphoma Cell Lines and Patients
Clin. Cancer Res.,
December 1, 2005;
11(23):
8250 - 8257.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Aldinucci, D. Poletto, D. Lorenzon, P. Nanni, M. Degan, K. Olivo, B. Rapana, A. Pinto, and V. Gattei
CD26 Expression Correlates with a Reduced Sensitivity to 2'-Deoxycoformycin-Induced Growth Inhibition and Apoptosis in T-Cell Leukemia/Lymphomas
Clin. Cancer Res.,
January 15, 2004;
10(2):
508 - 520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Belhadj, F. Reyes, J.-P. Farcet, H. Tilly, C. Bastard, R. Angonin, E. Deconinck, F. Charlotte, V. Leblond, E. Labouyrie, et al.
Hepatosplenic {gamma}{delta} T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients
Blood,
December 15, 2003;
102(13):
4261 - 4269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Aljurf, T. W. Owaidah, A. Ezzat, E. Ibrahim, and A. Tbakhi
Antigen- and/or immune-driven lymphoproliferative disorders
Ann. Onc.,
November 1, 2003;
14(11):
1595 - 1606.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Fry, W. Vernau, P. A. Pesavento, C. Bromel, and P. F. Moore
Hepatosplenic Lymphoma in a Dog
Veterinary Pathology,
September 1, 2003;
40(5):
556 - 562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Sadahira, K Notohara, and T Manabe
Hepatosplenic T cell lymphoma with no expression of cytotoxic molecules
J. Clin. Pathol.,
August 1, 2003;
56(8):
631 - 633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Toro, D. J. Liewehr, N. Pabby, L. Sorbara, M. Raffeld, S. M. Steinberg, and E. S. Jaffe
Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma
Blood,
May 1, 2003;
101(9):
3407 - 3412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Krenacs, M. J. Smyth, E. Bagdi, T. Krenacs, L. Kopper, T. Rudiger, A. Zettl, H. K. Muller-Hermelink, E. S. Jaffe, and M. Raffeld
The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity
Blood,
May 1, 2003;
101(9):
3590 - 3593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Nagata, A. Konno, N. Kimura, Y. Zhang, M. Kimura, A. Demachi, T. Sekine, K. Yamamoto, and N. Shimizu
Characterization of novel natural killer (NK)-cell and {gamma}{delta} T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus
Blood,
February 1, 2001;
97(3):
708 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Greer, M. C. Kinney, and T. P. Loughran Jr.
T Cell and NK Cell Lymphoproliferative Disorders
Hematology,
January 1, 2001;
2001(1):
259 - 281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Suzuki, Y. Kagami, K. Takeuchi, M. Kami, M. Okamoto, R. Ichinohasama, N. Mori, M. Kojima, T. Yoshino, H. Yamabe, et al.
Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype
Blood,
November 1, 2000;
96(9):
2993 - 3000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Toro, M. Beaty, L. Sorbara, M. L. Turner, J. White, D. W. Kingma, M. Raffeld, and E. S. Jaffe
{gamma}{delta} T-Cell Lymphoma of the Skin: A Clinical, Microscopic, and Molecular Study
Arch Dermatol,
August 1, 2000;
136(8):
1024 - 1032.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Kadin
Cutaneous {gamma}{delta} T-Cell Lymphomas--How and Why Should They Be Recognized?
Arch Dermatol,
August 1, 2000;
136(8):
1052 - 1054.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. K. Przybylski, H. Wu, W. R. Macon, J. Finan, D. G. B. Leonard, R. E. Felgar, J. A. DiGiuseppe, P. C. Nowell, S. H. Swerdlow, M. E. Kadin, et al.
Hepatosplenic and Subcutaneous Panniculitis-Like {gamma}/{delta} T Cell Lymphomas Are Derived from Different V{delta} Subsets of {gamma}/{delta} T Lymphocytes
J. Mol. Diagn.,
February 1, 2000;
2(1):
11 - 19.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Berti, D. Tomasini, M. H Vermeer, C. J. Meijer, E. Alessi, and R. Willemze
Primary Cutaneous CD8-Positive Epidermotropic Cytotoxic T Cell Lymphomas : A Distinct Clinicopathological Entity with an AggressiveClinical Behavior
Am. J. Pathol.,
August 1, 1999;
155(2):
483 - 492.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Chott, W. Haedicke, I. Mosberger, M. Fodinger, K. Winkler, C. Mannhalter, and H.-K. Muller-Hermelink
Most CD56+ Intestinal Lymphomas Are CD8+CD5- T-Cell Lymphomas of Monomorphic Small to Medium Size Histology
Am. J. Pathol.,
November 1, 1998;
153(5):
1483 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gisselbrecht, P. Gaulard, E. Lepage, B. Coiffier, J. Briere, C. Haioun, D. Cazals-Hatem, A. Bosly, L. Xerri, H. Tilly, et al.
Prognostic Significance of T-Cell Phenotype in Aggressive Non-Hodgkin's Lymphomas
Blood,
July 1, 1998;
92(1):
76 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Arnulf, C. Copie-Bergman, M.-H. Delfau-Larue, A. Lavergne-Slove, J. Bosq, J. Wechsler, M. Wassef, C. Matuchansky, B. Epardeau, M. Stern, et al.
Nonhepatosplenic gamma delta T-Cell Lymphoma: A Subset of Cytotoxic Lymphomas With Mucosal or Skin Localization
Blood,
March 1, 1998;
91(5):
1723 - 1731.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Suzuki, K. Yamamoto, M. Seto, Y. Kagami, M. Ogura, Y. Yatabe, T. Suchi, Y. Kodera, Y. Morishima, T. Takahashi, et al.
CD7+ and CD56+ Myeloid/Natural Killer Cell Precursor Acute Leukemia: A Distinct Hematolymphoid Disease Entity
Blood,
September 15, 1997;
90(6):
2417 - 2428.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K.C. Chan, V.C. Sin, K.F. Wong, C.S. Ng, W. Y.W. Tsang, C.H. Chan, M.M.C. Cheung, and W.H. Lau
Nonnasal Lymphoma Expressing the Natural Killer Cell Marker CD56: A Clinicopathologic Study of 49 Cases of an Uncommon Aggressive Neoplasm
Blood,
June 15, 1997;
89(12):
4501 - 4513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Salhany, M. Feldman, D. Peritt, and P. C. Nowell
Cytotoxic T-Lymphocyte Differentiation and Cytogenetic Alterations in gamma delta Hepatosplenic T-Cell Lymphoma and Posttransplant Lymphoproliferative Disorders
Blood,
May 1, 1997;
89(9):
3490 - 3490.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Krenacs, A. Wellmann, L. Sorbara, A. W. Himmelmann, E. Bagdi, E. S. Jaffe, and M. Raffeld
Cytotoxic Cell Antigen Expression in Anaplastic Large Cell Lymphomas of T- and Null-Cell Type and Hodgkin's Disease: Evidence for Distinct Cellular Origin
Blood,
February 1, 1997;
89(3):
980 - 989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
