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Functional properties of murine macrophages promoted by nerve growth factor
Y Susaki, S Shimizu, K Katakura, N Watanabe, K Kawamoto, M Matsumoto, M Tsudzuki, T Furusaka, Y Kitamura and H Matsuda
Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University
of Agriculture and Technology, Japan.
The stimulating effect of nerve growth factor (NGF) on phagocytosis,
parasite killing, and interleukin-1beta (IL-1beta) production of murine
peritoneal macrophages was assessed. In the presence of various doses of
NGF, macrophages showed the increased phagocytosis of both nonspecific
hydrophilic microspheres and sheep red blood cells (SRBC) opsonized with
anti-SRBC antibodies (Ab) or complement in a dose- dependent manner. NGF
also enhanced killing of Leishmania donovani promastigotes by macrophages,
and its ability was comparable with that of an optimal dose of recombinant
granulocyte-macrophage colony- stimulating factor or recombinant
interferon-gamma. The addition of NGF to peritoneal macrophages and
monocyte-macrophage J774A.1 cells led to a significant release of IL-1beta
in a dose-dependent manner and expression of IL-1beta mRNA. Because
pretreatment of peritoneal macrophages and J774A.1 cells with K-252a, a
tyrosine kinase inhibitor, completely suppressed these NGF-mediated
stimulating effects and p140trk phosphorylation and because flow cytometric
analysis with specific Ab against two distinct NGF receptors showed the
expression of p140trk, unlike p75LNGFR, on the surface of macrophages, the
stimulating activity of NGF to murine macrophages may be mediated through
p140trk. Thus, NGF may act as an activator for murine macrophages in the
process of inflammatory and immune actions.
Volume 88,
Issue 12,
pp. 4630-4637,
12/15/1996
Copyright © 1996 by The American Society of Hematology
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