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Adult T-cell leukemia/lymphoma on a background of clonally expanding human
T-cell leukemia virus type-1-positive cells
M Cavrois, S Wain-Hobson, A Gessain, Y Plumelle and E Wattel
Unite 124 INSERM, Institut de Recherche sur le Cancer de Lille, France.
Tumorous and nontumorous samples from patients with various forms of adult
T-cell leukemia/lymphoma (ATLL) were analyzed using the sensitive inverse
polymerase chain reaction (PCR) technique. In all samples, oligoclonal
expansion of human T-cell leukemia virus (HTLV)-1 bearing T cells were
detected, even for the tumorous samples that were mainly monoclonal by
Southern blotting. For one case of smouldering ATLL, chemotherapy
apparently reduced the number of detectable clones. Taken together with
similar data on asymptomatic and symptomatic HTLV-1 carriers without
malignancy, it would appear that ATLL appears on a prior background of
HTLV-1-initiated oligoclonal expansion.
Volume 88,
Issue 12,
pp. 4646-4650,
12/15/1996
Copyright © 1996 by The American Society of Hematology
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