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Human immunodeficiency virus (HIV) phenotype and interleukin-2/
interleukin-10 ratio are associated markers of protection and progression
in HIV infection
M Clerici, C Balotta, A Salvaggio, C Riva, D Trabattoni, L Papagno, A Berlusconi, S Rusconi, ML Villa, M Moroni and M Galli
Cattedra di Immunologia, Universita degli Studi di Milano, Padiglione
L.I.T.A., Ospedale Luigi Sacco, Italy.
Human immunodeficiency virus (HIV) isolability, rate of viral replication,
HIV phenotype, type 1 and type 2 cytokine production, and CD4 counts were
cross sectionally analyzed in 63 HIV seropositive (HIV+) individuals to
establish possible correlations between virologic and immunologic markers
of protection and progression. We observed that these markers are tightly
correlated. Thus, lack or low prevalence of HIV isolability and the
presence of nonsyncitium inducing strains are associated with the strongest
type 1 cytokine production, the weakest type 2 cytokine production, and
highest CD4 counts. Conversely, the isolation of highly replicating,
syncitium-inducing HIV strains is associated with the weakest type 1
cytokine production, the strongest type 2 cytokine production, and lowest
CD4 counts. Additionally, it was determined that the interleukin
(IL)-10/IL-2 ratio best discriminates among different virologic scenarios.
These data suggest that the virologic and immunologic correlates of disease
protection and progression might be associated variables that define two
different subsets of HIV+ individuals and lend support to a
viro-immunologic hypothesis of HIV infection.
Volume 88,
Issue 2,
pp. 574-579,
07/15/1996
Copyright © 1996 by The American Society of Hematology
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