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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nador, R. Articles by Knowles, D. Search for Related Content PubMed PubMed Citation Articles by Nador, R. Articles by Knowles, D. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus RG Nador, E Cesarman, A Chadburn, DB Dawson, MQ Ansari, J Sald and DM Knowles Department of Pathology, New York Hospital-Cornell Medical Center, New York 10021, USA. We recently discovered the Kaposi's sarcoma-associated herpes virus (KSHV/HHV-8) in an uncommon and unusual subset of AIDS-related lymphomas that grow mainly in the body cavities as lymphomatous effusions without an identifiable contiguous tumor mass. The consistent presence of KSHV and certain other distinctive features of these body cavity-based lymphomas suggest that they represent a distinct entity. We tested this hypothesis by investigating 19 malignant lymphomatous effusions occurring in the absence of a contiguous tumor mass for their clinical, morphologic, immunophenotypic, viral, and molecular characteristics, KSHV was present in 15 of 19 lymphomas. All four KSHV- negative lymphomatous effusions exhibited Burkitt or Burkitt-like morphology and c-myc gene rearrangements and, therefore, appeared to be Burkitt-type lymphomas occurring in the body cavities. In contrast, all 15 KSHV-positive lymphomatous effusions exhibited a distinctive morphology bridging large-cell immunoblastic lymphoma and anaplastic large-cell lymphoma, and all 12 cases studied lacked c-myc gene rearrangements. In addition, these lymphomas occurred in men (15/15), frequently but not exclusively in association with HIV infection (13/15), in which homosexuality was a risk factor (13/13), presented initially as a lymphomatous effusion (14/15), remained localized to the body cavity of origin (13/15), expressed CD45 (15/15) and one or more activation-associated antigens (9/10) in the frequent absence of B-cell- associated antigens (11/15), exhibited clonal immunoglobulin gene rearrangements (13/13), contained Epstein-Barr virus (14/15), and lacked bcl-2, bcl-6, ras and p53 gene alterations (13/15). These findings strongly suggest that the KSHV-positive malignant lymphomatous effusions represent a distinct clinicopathologic and biologic entity and should be distinguished from other malignant lymphomas occurring in the body cavities. Therefore, we recommend that these malignant lymphomas be designated primary effusion lymphomas (PEL), rather than body cavity-based lymphomas, since this term describes them more accurately and avoids their confusion with other malignant lymphomas that occur in the body cavities. We further recommend that these PEL be considered for inclusion as a new entity in the Revised European- American Lymphoma Classification. Volume 88, Issue 2, pp. 645-656, 07/15/1996 Copyright © 1996 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. YIAKOUMIS, G.A. PANGALIS, M-C. KYRTSONIS, T.P. VASSILAKOPOULOS, F.N. KONTOPIDOU, C. KALPADAKIS, P. 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[Abstract] [Full Text] [PDF] A. Carbone, E. Cesarman, M. Spina, A. Gloghini, and T. F. Schulz HIV-associated lymphomas and gamma-herpesviruses Blood, February 5, 2009; 113(6): 1213 - 1224. [Abstract] [Full Text] [PDF] A. Cassoni, U. Ali, J. Cave, S. G. Edwards, A. Ramsay, R. F. Miller, and S. M. Lee Remission After Radiotherapy for a Patient With Chemotherapy-Refractory HIV-Associated Primary Effusion Lymphoma J. Clin. Oncol., November 10, 2008; 26(32): 5297 - 5299. [Full Text] [PDF] P. Gasperini, S. Sakakibara, and G. Tosato Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis J. Leukoc. Biol., October 1, 2008; 84(4): 994 - 1000. [Abstract] [Full Text] [PDF] A. Kreuter, S. Bischoff, M. Skrygan, U. Wieland, N. H. Brockmeyer, M. Stucker, P. Altmeyer, and T. Gambichler High Association of Human Herpesvirus 8 in Large-Plaque Parapsoriasis and Mycosis Fungoides Arch Dermatol, August 1, 2008; 144(8): 1011 - 1016. [Abstract] [Full Text] [PDF] A. Carbone, A. Gloghini, and G. Dotti EBV-Associated Lymphoproliferative Disorders: Classification and Treatment Oncologist, May 1, 2008; 13(5): 577 - 585. [Abstract] [Full Text] [PDF] P.-C. Chang and M. Li Kaposi's Sarcoma-Associated Herpesvirus K-Cyclin Interacts with Cdk9 and Stimulates Cdk9-Mediated Phosphorylation of p53 Tumor Suppressor J. Virol., January 1, 2008; 82(1): 278 - 290. [Abstract] [Full Text] [PDF] D. Niino, K. Tsukasaki, K. Torii, D. Imanishi, T. Tsuchiya, Y. Onimaru, H. Tsushima, S. Yoshida, Y. Yamada, S. Kamihira, et al. Human Herpes virus 8-negative primary effusion lymphoma with BCL6 rearrangement in a patient with idiopathic CD4 positive T-lymphocytopenia Haematologica, January 1, 2008; 93(1): e21 - e23. [Abstract] [Full Text] [PDF] S. J. Wilson, E. H. Tsao, B. L. J. Webb, H. Ye, L. Dalton-Griffin, C. Tsantoulas, C. V. Gale, M.-Q. Du, A. Whitehouse, and P. Kellam X Box Binding Protein XBP-1s Transactivates the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF50 Promoter, Linking Plasma Cell Differentiation to KSHV Reactivation from Latency J. Virol., December 15, 2007; 81(24): 13578 - 13586. [Abstract] [Full Text] [PDF] M-Q Du, C M Bacon, and P G Isaacson Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders J. Clin. Pathol., December 1, 2007; 60(12): 1350 - 1357. [Abstract] [Full Text] [PDF] K L Grogg, R F Miller, and A Dogan HIV infection and lymphoma J. Clin. Pathol., December 1, 2007; 60(12): 1365 - 1372. [Abstract] [Full Text] [PDF] K. D. Carroll, F. Khadim, S. Spadavecchia, D. Palmeri, and D. M. Lukac Direct Interactions of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Protein with the Cellular Protein Octamer-1 and DNA Are Critical for Specifying Transactivation of a Delayed-Early Promoter and Stimulating Viral Reactivation J. Virol., August 15, 2007; 81(16): 8451 - 8467. [Abstract] [Full Text] [PDF] T. K. Nun, D. J. Kroll, N. H. Oberlies, D. D. Soejarto, R. J. Case, P. Piskaut, T. Matainaho, C. Hilscher, L. Wang, D. P. Dittmer, et al. Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus Mol. Cancer Ther., August 1, 2007; 6(8): 2360 - 2370. [Abstract] [Full Text] [PDF] D. A. Davis, K. E. Singer, I. P. Reynolds, M. Haque, and R. Yarchoan Hypoxia Enhances the Phosphorylation and Cytotoxicity of Ganciclovir and Zidovudine in Kaposi's Sarcoma-Associated Herpesvirus Infected Cells Cancer Res., July 15, 2007; 67(14): 7003 - 7010. [Abstract] [Full Text] [PDF] W. Bu, K. D. Carroll, D. Palmeri, and D. M. Lukac Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Lytic Switch Protein Functions as a Tetramer J. Virol., June 1, 2007; 81(11): 5788 - 5806. [Abstract] [Full Text] [PDF] Y.-B. Chen, A. Rahemtullah, and E. Hochberg Primary Effusion Lymphoma Oncologist, May 1, 2007; 12(5): 569 - 576. [Abstract] [Full Text] [PDF] A. R. Hussain, N. A. Al-Jomah, A. K. Siraj, P. Manogaran, K. Al-Hussein, J. Abubaker, L. C. Platanias, K. S. Al-Kuraya, and S. Uddin Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells Cancer Res., April 15, 2007; 67(8): 3888 - 3897. [Abstract] [Full Text] [PDF] C. E. Petre, S.-H. Sin, and D. P. Dittmer Functional p53 Signaling in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas: Implications for Therapy J. Virol., February 15, 2007; 81(4): 1912 - 1922. [Abstract] [Full Text] [PDF] H Narimatsu, Y Ota, M Kami, K Takeuchi, R Suzuki, K Matsuo, T Matsumura, K Yuji, Y Kishi, T Hamaki, et al. Clinicopathological features of pyothorax-associated lymphoma; a retrospective survey involving 98 patients Ann. Onc., January 1, 2007; 18(1): 122 - 128. [Abstract] [Full Text] [PDF] S Inoue, T Miyamoto, T Yoshino, I Yamadori, Y Hagari, and O Yamamoto Primary effusion lymphoma with skin involvement. J. Clin. Pathol., November 1, 2006; 59(11): 1221 - 1222. [Abstract] [Full Text] [PDF] D. Chen and J. Nicholas Structural Requirements for gp80 Independence of Human Herpesvirus 8 Interleukin-6 (vIL-6) and Evidence for gp80 Stabilization of gp130 Signaling Complexes Induced by vIL-6 J. Virol., October 1, 2006; 80(19): 9811 - 9821. [Abstract] [Full Text] [PDF] D. T. Scadden, V. V. Muse, and R. P. Hasserjian Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy. N. Engl. J. Med., September 28, 2006; 355(13): 1358 - 1368. [Full Text] [PDF] M. Kovaleva, I. Bussmeyer, B. Rabe, J. Grotzinger, E. Sudarman, J. Eichler, U. Conrad, S. Rose-John, and J. Scheller Abrogation of Viral Interleukin-6 (vIL-6)-Induced Signaling by Intracellular Retention and Neutralization of vIL-6 with an Anti-vIL-6 Single-Chain Antibody Selected by Phage Display J. Virol., September 1, 2006; 80(17): 8510 - 8520. [Abstract] [Full Text] [PDF] M. Arguello, S. Paz, E. Hernandez, C. Corriveau-Bourque, L. M. Fawaz, J. Hiscott, and R. Lin Leukotriene A4 Hydrolase Expression in PEL Cells Is Regulated at the Transcriptional Level and Leads to Increased Leukotriene B4 Production. J. Immunol., June 1, 2006; 176(11): 7051 - 7061. [Abstract] [Full Text] [PDF] C. L. Langlais, J. M. Jones, R. D. Estep, and S. W. Wong Rhesus Rhadinovirus R15 Encodes a Functional Homologue of Human CD200 J. Virol., March 15, 2006; 80(6): 3098 - 3103. [Abstract] [Full Text] [PDF] E. L. Wong and B. Damania Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus K15 Gene J. Virol., February 1, 2006; 80(3): 1385 - 1392. [Abstract] [Full Text] [PDF] A. L. Steed, E. S. Barton, S. A. Tibbetts, D. L. Popkin, M. L. Lutzke, R. Rochford, and H. W. Virgin IV Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency J. Virol., January 1, 2006; 80(1): 192 - 200. [Abstract] [Full Text] [PDF] L. Chen and M. Lagunoff Establishment and Maintenance of Kaposi's Sarcoma-Associated Herpesvirus Latency in B Cells J. Virol., November 15, 2005; 79(22): 14383 - 14391. [Abstract] [Full Text] [PDF] E. Trento, C. Castilletti, C. Ferraro, I. Lesnoni La Parola, A. Mussi, L. Muscardin, V. Bordignon, G. D'Agosto, A. Amantea, A. Mastroianni, et al. Human Herpesvirus 8 Infection in Patients With Cutaneous Lymphoproliferative Diseases Arch Dermatol, October 1, 2005; 141(10): 1235 - 1242. [Abstract] [Full Text] [PDF] E. Boulanger, L. Gerard, J. Gabarre, J.-M. Molina, C. Rapp, J.-F. Abino, J. Cadranel, S. Chevret, and E. Oksenhendler Prognostic Factors and Outcome of Human Herpesvirus 8-Associated Primary Effusion Lymphoma in Patients With AIDS J. Clin. Oncol., July 1, 2005; 23(19): 4372 - 4380. [Abstract] [Full Text] [PDF] H. Chang, Y. Gwack, D. Kingston, J. Souvlis, X. Liang, R. E. Means, E. Cesarman, L. Hutt-Fletcher, and J. U. Jung Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA J. Virol., April 15, 2005; 79(8): 4651 - 4663. [Abstract] [Full Text] [PDF] S. Uddin, A. R. Hussain, K. A. Al-Hussein, P. S. Manogaran, A. Wickrema, M. I. Gutierrez, and K. G. Bhatia Inhibition of Phosphatidylinositol 3'-Kinase/AKT Signaling Promotes Apoptosis of Primary Effusion Lymphoma Cells Clin. Cancer Res., April 15, 2005; 11(8): 3102 - 3108. [Abstract] [Full Text] [PDF] A. Godfrey, J. Anderson, A. Papanastasiou, Y. Takeuchi, and C. Boshoff Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA Blood, March 15, 2005; 105(6): 2510 - 2518. [Abstract] [Full Text] [PDF] S. Borah, S. C. Verma, and E. S. Robertson ORF73 of Herpesvirus Saimiri, a Viral Homolog of Kaposi's Sarcoma-Associated Herpesvirus, Modulates the Two Cellular Tumor Suppressor Proteins p53 and pRb J. Virol., October 1, 2004; 78(19): 10336 - 10347. [Abstract] [Full Text] [PDF] I. Guasparri, S. A. Keller, and E. Cesarman KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells J. Exp. Med., April 5, 2004; 199(7): 993 - 1003. [Abstract] [Full Text] [PDF] M. G. Alexandrakis, F. H. Passam, D. S. Kyriakou, and D. Bouros Pleural Effusions in Hematologic Malignancies Chest, April 1, 2004; 125(4): 1546 - 1555. [Abstract] [Full Text] [PDF] J. An, Y. Sun, and M. B. Rettig Transcriptional coactivation of c-Jun by the KSHV-encoded LANA Blood, January 1, 2004; 103(1): 222 - 228. [Abstract] [Full Text] [PDF] P. Trivedi, K. Takazawa, C. Zompetta, L. Cuomo, E. Anastasiadou, A. Carbone, S. Uccini, F. Belardelli, K. Takada, L. Frati, et al. Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein-Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression Blood, January 1, 2004; 103(1): 313 - 316. [Abstract] [Full Text] [PDF] S. C. Verma and E. S. Robertson ORF73 of Herpesvirus Saimiri Strain C488 Tethers the Viral Genome to Metaphase Chromosomes and Binds to cis-Acting DNA Sequences in the Terminal Repeats J. Virol., December 1, 2003; 77(23): 12494 - 12506. [Abstract] [Full Text] [PDF] S. Delorme, I. Houde, and L. Deschenes Seroprevalence of Antibodies against Human Herpesvirus 8 in a Population of Renal Transplant Recipients at Hotel-Dieu de Quebec Hospital J. Clin. Microbiol., November 1, 2003; 41(11): 5207 - 5208. [Abstract] [Full Text] [PDF] C. Simonelli, M. Spina, R. Cinelli, R. Talamini, R. Tedeschi, A. Gloghini, E. Vaccher, A. Carbone, and U. Tirelli Clinical Features and Outcome of Primary Effusion Lymphoma in HIV-Infected Patients: A Single-Institution Study J. Clin. Oncol., November 1, 2003; 21(21): 3948 - 3954. [Abstract] [Full Text] [PDF] L. A. Dourmishev, A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis Microbiol. Mol. Biol. Rev., June 1, 2003; 67(2): 175 - 212. [Abstract] [Full Text] [PDF] S. K. Ghosh, C. Wood, L. H. Boise, A. M. Mian, V. V. Deyev, G. Feuer, N. L. Toomey, N. C. Shank, L. Cabral, G. N. Barber, et al. Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-kappa B Blood, March 15, 2003; 101(6): 2321 - 2327. [Abstract] [Full Text] [PDF] H.-G. Guo, M. Sadowska, W. Reid, E. Tschachler, G. Hayward, and M. Reitz Kaposi's Sarcoma-Like Tumors in a Human Herpesvirus 8 ORF74 Transgenic Mouse J. Virol., February 15, 2003; 77(4): 2631 - 2639. [Abstract] [Full Text] [PDF] Y. Aoki, G. M. Feldman, and G. Tosato Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma Blood, February 15, 2003; 101(4): 1535 - 1542. [Abstract] [Full Text] [PDF] R. D. Estep, M. K. Axthelm, and S. W. Wong A G Protein-Coupled Receptor Encoded by Rhesus Rhadinovirus Is Similar to ORF74 of Kaposi's Sarcoma-Associated Herpesvirus J. Virol., February 1, 2003; 77(3): 1738 - 1746. [Abstract] [Full Text] [PDF] P. A. Volberding, K. R. Baker, and A. M. Levine Human Immunodeficiency Virus Hematology Hematology, January 1, 2003; 2003(1): 294 - 313. [Abstract] [Full Text] [PDF] M.-Q. Du, T. C. Diss, H. Liu, H. Ye, R. A. Hamoudi, J. Cabecadas, H. Y. Dong, N. L. Harris, J. K. C. Chan, J. W. Rees, et al. KSHV- and EBV-associated germinotropic lymphoproliferative disorder Blood, October 16, 2002; 100(9): 3415 - 3418. [Abstract] [Full Text] [PDF] P Ryan, S Aarons, D Murray, T Markham, S O'Sullivan, F Lyons, G Lee, and J Fitzgibbon Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma J. Clin. Pathol., August 1, 2002; 55(8): 619 - 622. [Abstract] [Full Text] [PDF] D. V. Ablashi, L. G. Chatlynne, J. E. Whitman Jr., and E. Cesarman Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases Clin. Microbiol. Rev., July 1, 2002; 15(3): 439 - 464. [Abstract] [Full Text] [PDF] H. Li and J. Nicholas Identification of Amino Acid Residues of gp130 Signal Transducer and gp80 {alpha} Receptor Subunit That Are Involved in Ligand Binding and Signaling by Human Herpesvirus 8-Encoded Interleukin-6 J. Virol., June 1, 2002; 76(11): 5627 - 5636. [Abstract] [Full Text] [PDF] M. W. Otieno, C. Banura, E. Katongole-Mbidde, J. L. Johnson, M. Ghannoum, A. Dowlati, R. Renne, E. Arts, C. Whalen, M. M. Lederman, et al. Therapeutic Challenges of AIDS-Related Non-Hodgkin's Lymphoma in the United States and East Africa J Natl Cancer Inst, May 15, 2002; 94(10): 718 - 732. [Abstract] [Full Text] [PDF] S. Tang and Z.-M. Zheng Kaposi's Sarcoma-associated Herpesvirus K8 Exon 3 Contains Three 5'-Splice Sites and Harbors a K8.1 Transcription Start Site J. Biol. Chem., April 19, 2002; 277(17): 14547 - 14556. [Abstract] [Full Text] [PDF] M. J. Lock, N. Thorley, J. Teo, and V. C. Emery Azidodeoxythymidine and didehydrodeoxythymidine as inhibitors and substrates of the human herpesvirus 8 thymidine kinase J. Antimicrob. Chemother., February 1, 2002; 49(2): 359 - 366. [Abstract] [Full Text] [PDF] O. Kirk, C. Pedersen, A. Cozzi-Lepri, F. Antunes, V. Miller, J. M. Gatell, C. Katlama, A. Lazzarin, P. Skinhoj, and S. E. Barton Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy Blood, December 1, 2001; 98(12): 3406 - 3412. [Abstract] [Full Text] [PDF] C. L. Perez and S. Rudoy Anti-CD20 Monoclonal Antibody Treatment of Human Herpesvirus 8-Associated, Body Cavity-Based Lymphoma with an Unusual Phenotype in a Human Immunodeficiency Virus-Negative Patient Clin. Vaccine Immunol., September 1, 2001; 8(5): 993 - 996. [Abstract] [Full Text] [PDF] S. Sakurada, H. Katano, T. Sata, H. Ohkuni, T. Watanabe, and S. Mori Effective Human Herpesvirus 8 Infection of Human Umbilical Vein Endothelial Cells by Cell-Mediated Transmission J. Virol., August 15, 2001; 75(16): 7717 - 7722. [Abstract] [Full Text] [PDF] T. Piolot, M. Tramier, M. Coppey, J.-C. Nicolas, and V. Marechal Close but Distinct Regions of Human Herpesvirus 8 Latency-Associated Nuclear Antigen 1 Are Responsible for Nuclear Targeting and Binding to Human Mitotic Chromosomes J. Virol., April 15, 2001; 75(8): 3948 - 3959. [Abstract] [Full Text] [PDF] M.-Q. Du, H. Liu, T. C. Diss, H. Ye, R. A. Hamoudi, N. Dupin, V. Meignin, E. Oksenhendler, C. Boshoff, and P. G. Isaacson Kaposi sarcoma-associated herpesvirus infects monotypic (IgM{lambda}) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders Blood, April 1, 2001; 97(7): 2130 - 2136. [Abstract] [Full Text] [PDF] F. Samaniego, S. Pati, J. E. Karp, O. Prakash, and D. Bose Human Herpesvirus 8 K1-Associated Nuclear Factor-kappa B-Dependent Promoter Activity: Role in Kaposi's Sarcoma Inflammation? J Natl Cancer Inst Monographs, December 1, 2000; 2000(28): 15 - 23. [Abstract] [Full Text] [PDF] J. S. Cannon, D. Ciufo, A. L. Hawkins, C. A. Griffin, M. J. Borowitz, G. S. Hayward, and R. F. Ambinder A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant J. Virol., November 1, 2000; 74(21): 10187 - 10193. [Abstract] [Full Text] [PDF] A. Krithivas, D. B. Young, G. Liao, D. Greene, and S. D. Hayward Human Herpesvirus 8 LANA Interacts with Proteins of the mSin3 Corepressor Complex and Negatively Regulates Epstein-Barr Virus Gene Expression in Dually Infected PEL Cells J. Virol., October 15, 2000; 74(20): 9637 - 9645. [Abstract] [Full Text] [PDF] S. A. Keller, E. J. Schattner, and E. Cesarman Inhibition of NF-kappa B induces apoptosis of KSHV-infected primary effusion lymphoma cells Blood, October 1, 2000; 96(7): 2537 - 2542. [Abstract] [Full Text] [PDF] B. Lubyova and P. M. Pitha Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors J. Virol., September 1, 2000; 74(17): 8194 - 8201. [Abstract] [Full Text] [PDF] Y. Aoki, R. Yarchoan, J. Braun, A. Iwamoto, and G. Tosato Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions Blood, August 15, 2000; 96(4): 1599 - 1601. [Abstract] [Full Text] [PDF] Y.-J. Zhang, J.-H. Deng, C. Rabkin, and S.-J. Gao Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR-RFLP J. Gen. Virol., August 1, 2000; 81(8): 2049 - 2058. [Abstract] [Full Text] R. Weiss and C. Boshoff Addressing Controversies Over Kaposi's Sarcoma J Natl Cancer Inst, May 3, 2000; 92(9): 677 - 679. [Full Text] [PDF] J.-G. Judde, V. Lacoste, J. Briere, E. Kassa-Kelembho, E. Clyti, P. Couppie, C. Buchrieser, M. Tulliez, J. Morvan, and A. Gessain Monoclonality or Oligoclonality of Human Herpesvirus 8 Terminal Repeat Sequences in Kaposi's Sarcoma and Other Diseases J Natl Cancer Inst, May 3, 2000; 92(9): 729 - 736. [Abstract] [Full Text] [PDF] J. Mullberg, T. Geib, T. Jostock, S. H. Hoischen, P. Vollmer, N. Voltz, D. Heinz, P. R. Galle, M. Klouche, and S. Rose-John IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6 J. Immunol., May 1, 2000; 164(9): 4672 - 4677. [Abstract] [Full Text] [PDF] F. Pica, A. Volpi, A. Serafino, M. Fraschetti, O. Franzese, and E. Garaci Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8-infected primary effusion lymphoma cells Blood, May 1, 2000; 95(9): 2905 - 2912. [Abstract] [Full Text] [PDF] H. Katano, T. Iwasaki, N. Baba, M. Terai, S. Mori, A. Iwamoto, T. Kurata, and T. Sata Identification of Antigenic Proteins Encoded by Human Herpesvirus 8 and Seroprevalence in the General Population and among Patients with and without Kaposi's Sarcoma J. Virol., April 15, 2000; 74(8): 3478 - 3485. [Abstract] [Full Text] [PDF] L. Alexander, L. Denekamp, A. Knapp, M. R. Auerbach, B. Damania, and R. C. Desrosiers The Primary Sequence of Rhesus Monkey Rhadinovirus Isolate 26-95: Sequence Similarities to Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Monkey Rhadinovirus Isolate 17577 J. Virol., April 1, 2000; 74(7): 3388 - 3398. [Abstract] [Full Text] [PDF] T. Hideshima, D. Chauhan, G. Teoh, N. Raje, S. P. Treon, Y.-T. Tai, Y. Shima, and K. C. Anderson Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi's Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6 Clin. Cancer Res., March 1, 2000; 6(3): 1180 - 1189. [Abstract] [Full Text] N. Dupin, T. L. Diss, P. Kellam, M. Tulliez, M.-Q. Du, D. Sicard, R. A. Weiss, P. G. Isaacson, and C. Boshoff HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma Blood, February 15, 2000; 95(4): 1406 - 1412. [Abstract] [Full Text] [PDF] T.-Y. Yang, S.-C. Chen, M. W. Leach, D. Manfra, B. Homey, M. Wiekowski, L. Sullivan, C.-H. Jenh, S. K. Narula, S. W. Chensue, et al. Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma J. Exp. Med., February 7, 2000; 191(3): 445 - 454. [Abstract] [Full Text] [PDF] A. J. Aguirre and E. S. Robertson Epstein-Barr Virus Recombinants from BC-1 and BC-2 Can Immortalize Human Primary B Lymphocytes with Different Levels of Efficiency and in the Absence of Coinfection by Kaposi's Sarcoma-Associated Herpesvirus J. Virol., January 15, 2000; 74(2): 735 - 743. [Abstract] [Full Text] [PDF] Y. Aoki and G. Tosato Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas Blood, December 15, 1999; 94(12): 4247 - 4254. [Abstract] [Full Text] [PDF] K. D. Jones, Y. Aoki, Y. Chang, P. S. Moore, R. Yarchoan, and G. Tosato Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi's Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells Blood, October 15, 1999; 94(8): 2871 - 2879. [Abstract] [Full Text] [PDF] A. Ibrahimbacha, M. Farah, and J. Saluja An HIV-Infected Patient With Pleural Effusion Chest, October 1, 1999; 116(4): 1113 - 1115. [Full Text] [PDF] S. W. Wong, E. P. Bergquam, R. M. Swanson, F. W. Lee, S. M. Shiigi, N. A. Avery, J. W. Fanton, and M. K. Axthelm Induction of B Cell Hyperplasia in Simian Immunodeficiency Virus-Infected Rhesus Macaques with the Simian Homologue of Kaposi's Sarcoma-Associated Herpesvirus J. Exp. Med., September 20, 1999; 190(6): 827 - 840. [Abstract] [Full Text] [PDF] M. Teitell, M. A. Damore, G. G. Sulur, D. E. Turner, M.-H. Stern, J. W. Said, C. T. Denny, and R. Wall TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues PNAS, August 17, 1999; 96(17): 9809 - 9814. [Abstract] [Full Text] [PDF] M. Burger, J. A. Burger, R. C. Hoch, Z. Oades, H. Takamori, and I. U. Schraufstatter Point Mutation Causing Constitutive Signaling of CXCR2 Leads to Transforming Activity Similar to Kaposi's Sarcoma Herpesvirus-G Protein-Coupled Receptor J. Immunol., August 15, 1999; 163(4): 2017 - 2022. [Abstract] [Full Text] [PDF] H. Katano, Y. Sato, T. Kurata, S. Mori, and T. Sata High Expression of HHV-8-Encoded ORF73 Protein in Spindle-Shaped Cells of Kaposi's Sarcoma Am. J. Pathol., July 1, 1999; 155(1): 47 - 52. [Abstract] [Full Text] [PDF] M. J. Endres, C. G. Garlisi, H. Xiao, L. Shan, and J. A. Hedrick The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8 J. Exp. Med., June 21, 1999; 189(12): 1993 - 1998. [Abstract] [Full Text] [PDF] Y. Aoki, E. S. Jaffe, Y. Chang, K. Jones, J. Teruya-Feldstein, P. S. Moore, and G. Tosato Angiogenesis and Hematopoiesis Induced by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Interleukin-6 Blood, June 15, 1999; 93(12): 4034 - 4043. [Abstract] [Full Text] [PDF] N. Dupin, C. Fisher, P. Kellam, S. Ariad, M. Tulliez, N. Franck, E. van Marck, D. Salmon, I. Gorin, J.-P. Escande, et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma PNAS, April 13, 1999; 96(8): 4546 - 4551. [Abstract] [Full Text] [PDF] R. P. Searles, E. P. Bergquam, M. K. Axthelm, and S. W. Wong Sequence and Genomic Analysis of a Rhesus Macaque Rhadinovirus with Similarity to Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 J. Virol., April 1, 1999; 73(4): 3040 - 3053. [Abstract] [Full Text] [PDF] A. Matolcsy, R. G. Nador, E. Cesarman, and D. M. Knowles Immunoglobulin VH Gene Mutational Analysis Suggests that Primary Effusion Lymphomas Derive from Different Stages of B Cell Maturation Am. J. Pathol., November 1, 1998; 153(5): 1609 - 1614. [Abstract] [Full Text] [PDF] E. Geras-Raaka, A. Varma, H. Ho, I. Clark-Lewis, and M. C. Gershengorn Human Interferon-{gamma}-inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor J. Exp. Med., July 20, 1998; 188(2): 405 - 408. [Abstract] [Full Text] [PDF] J. A. Reed, R. G. Nador, D. Spaulding, Y. Tani, E. Cesarman, and D. M. Knowles Demonstration of Kaposi's Sarcoma-Associated Herpes Virus Cyclin D Homolog in Cutaneous Kaposi's Sarcoma by Colorimetric In Situ Hybridization Using a Catalyzed Signal Amplification System Blood, May 15, 1998; 91(10): 3825 - 3832. [Abstract] [Full Text] [PDF] L. D. Kaplan Clinical Management of Human Immunodeficiency Virus-Associated Non-Hodgkin's Lymphoma J Natl Cancer Inst Monographs, April 1, 1998; 1998(23): 101 - 105. [Full Text] H. Asou, J. W. Said, R. Yang, R. Munker, D. J. Park, N. Kamada, and H. P. Koeffler Mechanisms of Growth Control of Kaposi's Sarcoma-Associated Herpes Virus-Associated Primary Effusion Lymphoma Cells Blood, April 1, 1998; 91(7): 2475 - 2481. [Abstract] [Full Text] [PDF] E. Geras-Raaka, L. Arvanitakis, C. Bais, E. Cesarman, E. A. Mesri, and M. C. Gershengorn Inhibition of Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-Coupled Receptor by Protein Kinases in Mammalian Cells in Culture J. Exp. Med., March 2, 1998; 187(5): 801 - 806. [Abstract] [Full Text] [PDF]

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