SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Weber-Nordt, R. Articles by Finke, J Search for Related Content PubMed PubMed Citation Articles by Weber-Nordt, R. Articles by Finke, J Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines RM Weber-Nordt, C Egen, J Wehinger, W Ludwig, V Gouilleux-Gruart, R Mertelsmann and J Finke Department of Hematology & Oncology, Albert-Ludwigs-University Medical Center, Freiburg, Germany. Although various molecular mechanisms of STAT protein (signal transducers and activators of transcription) activation have been identified, little is known about the functional role of STAT-dependent transcriptional activation. Herein we report the constitutive nuclear localization, phosphorylation, and DNA-binding activity of STAT proteins in leukemia cells and lymphoma cell lines. With the use of oligonucleotide probes derived from the Fc gamma RI promoter, the beta- casein promoter and a STAT-binding element in the promoter of the Bci-2 gene constitutive activation of STAT proteins was detected in untreated acute T- and C/B-leukemia cells (3 of 5 and 12 of 19 patients, respectively). Supershift analyses using Stats 1-6 specific antisera showed the constitutive DNA binding activity of Stat5 in these cells. Confocal microscopy revealed the nuclear localization of Stat5 and Western blot analyses showed tyrosine phosphorylation of Stat5 in nuclear extracts of acute leukemia cells. In contrast, peripheral blood mononuclear cells did not display constitutive STAT-DNA interaction. Further studies were performed on freshly isolated acute myeloid leukemia cells as well as on cell line derived K562, lymphoblastoid cells (LCL), and Burkitt's lymphoma cells (BL). Fluorescence microscopy, gelshift, and supershift experiments showed the nuclear localization and constitutive DNA-binding activity of Stat5 in K562 cells. Stat1 and Stat3 were constitutively activated in freshly isolated AML cells (10 of 14 patients) and in Epstein Barr virus- positive or interleukin-10 expressing permanent LCL and BL cells. Thus, these data indicate a differential pattern of STAT protein activation in lymphoid or myeloid leukemia and in lymphoma cells. Volume 88, Issue 3, pp. 809-816, 08/01/1996 Copyright © 1996 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. E. Hays Heterogeneity in the AML stem cell pool Blood, November 5, 2009; 114(19): 3976 - 3977. [Full Text] [PDF] M. Heuser, L. M. Sly, B. Argiropoulos, F. Kuchenbauer, C. Lai, A. Weng, M. Leung, G. Lin, C. Brookes, S. Fung, et al. Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal Blood, November 5, 2009; 114(19): 3983 - 3993. [Abstract] [Full Text] [PDF] M. Benekli, H. Baumann, and M. Wetzler Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias J. Clin. Oncol., September 10, 2009; 27(26): 4422 - 4432. [Abstract] [Full Text] [PDF] J. Alvaro-Blanco, L. Martinez-Gac, E. Calonge, M. Rodriguez-Martinez, I. Molina-Privado, J. M. Redondo, J. Alcami, E. K. Flemington, and M. R. Campanero A novel factor distinct from E2F mediates C-MYC promoter activation through its E2F element during exit from quiescence Carcinogenesis, March 1, 2009; 30(3): 440 - 448. [Abstract] [Full Text] [PDF] J. Nakayama, M. Yamamoto, K. Hayashi, H. Satoh, K. Bundo, M. Kubo, R. Goitsuka, M. A. Farrar, and D. Kitamura BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3 Blood, February 12, 2009; 113(7): 1483 - 1492. [Abstract] [Full Text] [PDF] A. Tun-Kyi, J. -Z. Qin, P. A. Oberholzer, A. A. Navarini, J. C. Hassel, R. Dummer, and U. Dobbeling Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model Ann. Onc., August 1, 2008; 19(8): 1488 - 1494. [Abstract] [Full Text] [PDF] J. McLaren, M. Rowe, and P. Brennan Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes J. Gen. Virol., July 1, 2007; 88(7): 1876 - 1886. [Abstract] [Full Text] [PDF] R. Hochreiter, C. Ptaschinski, S. L. Kunkel, and R. Rochford Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation J. Gen. Virol., July 1, 2007; 88(7): 1896 - 1905. [Abstract] [Full Text] [PDF] L. M. Williams, U. Sarma, K. Willets, T. Smallie, F. Brennan, and B. M. J. Foxwell Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages J. Biol. Chem., March 9, 2007; 282(10): 6965 - 6975. [Abstract] [Full Text] [PDF] Z. S. Nagy, H. Rui, S. M. Stepkowski, J. Karras, and R. A. Kirken A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor J. Immunol., October 15, 2006; 177(8): 5032 - 5040. [Abstract] [Full Text] [PDF] J. Kuroda, H. Puthalakath, M. S. Cragg, P. N. Kelly, P. Bouillet, D. C. S. Huang, S. Kimura, O. G. Ottmann, B. J. Druker, A. Villunger, et al. Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic PNAS, October 3, 2006; 103(40): 14907 - 14912. [Abstract] [Full Text] [PDF] Y. Chen, X. Dai, A. L. Haas, R. Wen, and D. Wang Proteasome-dependent down-regulation of activated Stat5A in the nucleus Blood, July 15, 2006; 108(2): 566 - 574. [Abstract] [Full Text] [PDF] M. M. Brinkmann and T. F. Schulz Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae. J. Gen. Virol., May 1, 2006; 87(Pt 5): 1047 - 1074. [Abstract] [Full Text] [PDF] Y. Zhang, R. A. Kirken, L. Furian, S. Janczewska, X. Qu, W. W. Hancock, M. Wang, N. Tejpal, R. Kerman, B. D. Kahan, et al. Allograft Rejection Requires STAT5a/b-Regulated Antiapoptotic Activity in T Cells but Not B Cells J. Immunol., January 1, 2006; 176(1): 128 - 137. [Abstract] [Full Text] [PDF] T. Higashi, J. Tsukada, Y. Yoshida, T. Mizobe, F. Mouri, Y. Minami, H. Morimoto, and Y. Tanaka Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I Genes Cells, December 1, 2005; 10(12): 1153 - 1162. [Abstract] [Full Text] [PDF] R. Avellino, S. Romano, R. Parasole, R. Bisogni, A. Lamberti, V. Poggi, S. Venuta, and M. F. Romano Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells Blood, August 15, 2005; 106(4): 1400 - 1406. [Abstract] [Full Text] [PDF] D. Yu, M. Dews, A. Park, J. W. Tobias, and A. Thomas-Tikhonenko Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies Cancer Res., June 15, 2005; 65(12): 5454 - 5461. [Abstract] [Full Text] [PDF] E. Heck, D. Lengenfelder, M. Schmidt, I. Muller-Fleckenstein, B. Fleckenstein, B. Biesinger, and A. Ensser T-Cell Growth Transformation by Herpesvirus Saimiri Is Independent of STAT3 Activation J. Virol., May 1, 2005; 79(9): 5713 - 5720. [Abstract] [Full Text] [PDF] I. Najjar, F. Baran-Marszak, C. Le Clorennec, C. Laguillier, O. Schischmanoff, I. Youlyouz-Marfak, M. Schlee, G. W. Bornkamm, M. Raphael, J. Feuillard, et al. Latent Membrane Protein 1 Regulates STAT1 through NF-{kappa}B-Dependent Interferon Secretion in Epstein-Barr Virus-Immortalized B Cells J. Virol., April 15, 2005; 79(8): 4936 - 4943. [Abstract] [Full Text] [PDF] V. Moucadel and S. N. Constantinescu Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors J. Biol. Chem., April 8, 2005; 280(14): 13364 - 13373. [Abstract] [Full Text] [PDF] M. Rahmani, E. Reese, Y. Dai, C. Bauer, L. B. Kramer, M. Huang, R. Jove, P. Dent, and S. Grant Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl+ Cells Sensitive and Resistant to STI571 (Imatinib Mesylate) in Association with Down-Regulation of Bcr-Abl, Abrogation of Signal Transducer and Activator of Transcription 5 Activity, and Bax Conformational Change Mol. Pharmacol., April 1, 2005; 67(4): 1166 - 1176. [Abstract] [Full Text] [PDF] F. Baran-Marszak, J. Feuillard, I. Najjar, C. Le Clorennec, J.-M. Bechet, I. Dusanter-Fourt, G. W. Bornkamm, M. Raphael, and R. Fagard Differential roles of STAT1{alpha} and STAT1{beta} in fludarabine-induced cell cycle arrest and apoptosis in human B cells Blood, October 15, 2004; 104(8): 2475 - 2483. [Abstract] [Full Text] [PDF] H. Siavash, N.G. Nikitakis, and J.J. Sauk SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 298 - 307. [Abstract] [Full Text] [PDF] L. Gate, R. S. Majumdar, A. Lunk, and K. D. Tew Increased Myeloproliferation in Glutathione S-Transferase {pi}-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways J. Biol. Chem., March 5, 2004; 279(10): 8608 - 8616. [Abstract] [Full Text] [PDF] D. W. Sternberg and D. G. Gilliland The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis J. Clin. Oncol., January 15, 2004; 22(2): 361 - 371. [Abstract] [Full Text] [PDF] F. Behbod, Z. S. Nagy, S. M. Stepkowski, J. Karras, C. R. Johnson, W. D. Jarvis, and R. A. Kirken Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells J. Immunol., October 15, 2003; 171(8): 3919 - 3927. [Abstract] [Full Text] [PDF] A. C. Bharti, N. Donato, and B. B. Aggarwal Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells J. Immunol., October 1, 2003; 171(7): 3863 - 3871. [Abstract] [Full Text] [PDF] R. R. Nepomuceno, C. E. Balatoni, Y. Natkunam, A. L. Snow, S. M. Krams, and O. M. Martinez Rapamycin Inhibits the Interleukin 10 Signal Transduction Pathway and the Growth of Epstein Barr Virus B-cell Lymphomas Cancer Res., August 1, 2003; 63(15): 4472 - 4480. [Abstract] [Full Text] [PDF] V. Sriuranpong, J. I. Park, P. Amornphimoltham, V. Patel, B. D. Nelkin, and J. S. Gutkind Epidermal Growth Factor Receptor-independent Constitutive Activation of STAT3 in Head and Neck Squamous Cell Carcinoma Is Mediated by the Autocrine/Paracrine Stimulation of the Interleukin 6/gp130 Cytokine System Cancer Res., June 1, 2003; 63(11): 2948 - 2956. [Abstract] [Full Text] [PDF] K. Spiekermann, K. Bagrintseva, R. Schwab, K. Schmieja, and W. Hiddemann Overexpression and Constitutive Activation of FLT3 Induces STAT5 Activation in Primary Acute Myeloid Leukemia Blast Cells Clin. Cancer Res., June 1, 2003; 9(6): 2140 - 2150. [Abstract] [Full Text] [PDF] M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler Signal transducer and activator of transcription proteins in leukemias Blood, April 15, 2003; 101(8): 2940 - 2954. [Abstract] [Full Text] [PDF] C. Richardson, C. Fielding, M. Rowe, and P. Brennan Epstein-Barr Virus Regulates STAT1 through Latent Membrane Protein 1 J. Virol., April 1, 2003; 77(7): 4439 - 4443. [Abstract] [Full Text] [PDF] P. L. Leong, G. A. Andrews, D. E. Johnson, K. F. Dyer, S. Xi, J. C. Mai, P. D. Robbins, S. Gadiparthi, N. A. Burke, S. F. Watkins, et al. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth PNAS, April 1, 2003; 100(7): 4138 - 4143. [Abstract] [Full Text] [PDF] S. Alas and B. Bonavida Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin's Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis Clin. Cancer Res., January 1, 2003; 9(1): 316 - 326. [Abstract] [Full Text] [PDF] T. Ikeda, K. Sato, N. Kuwada, T. Matsumura, T. Yamashita, F. Kimura, K. Hatake, K. Ikeda, and K. Motoyoshi Interleukin-10 differently regulates monocyte chemoattractant protein-1 gene expression depending on the environment in a human monoblastic cell line, UG3 J. Leukoc. Biol., December 1, 2002; 72(6): 1198 - 1205. [Abstract] [Full Text] [PDF] H. Ben-Bassat, Z. Hartzstark, R. Levitzki, B. Y. Klein, Z. Shlomai, A. Gazit, and A. Levitzki Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 163 - 171. [Abstract] [Full Text] [PDF] U. Testa, R. Riccioni, S. Militi, E. Coccia, E. Stellacci, P. Samoggia, R. Latagliata, G. Mariani, A. Rossini, A. Battistini, et al. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis Blood, September 26, 2002; 100(8): 2980 - 2988. [Abstract] [Full Text] [PDF] L. Burdelya, R. Catlett-Falcone, A. Levitzki, F. Cheng, L. B. Mora, E. Sotomayor, D. Coppola, J. Sun, S. Sebti, W. S. Dalton, et al. Combination Therapy with AG-490 and Interleukin 12 Achieves Greater Antitumor Effects than Either Agent Alone Mol. Cancer Ther., September 1, 2002; 1(11): 893 - 899. [Abstract] [Full Text] [PDF] Y. Gwack, S. Hwang, C. Lim, Y. S. Won, C. H. Lee, and J. Choe Kaposi's Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3 J. Biol. Chem., February 15, 2002; 277(8): 6438 - 6442. [Abstract] [Full Text] [PDF] M. Benekli, Z. Xia, K. A. Donohue, L. A. Ford, L. A. Pixley, M. R. Baer, H. Baumann, and M. Wetzler Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival Blood, January 1, 2002; 99(1): 252 - 257. [Abstract] [Full Text] [PDF] H. H. Lemmink, L. Tuyt, G. Knol, E. Krikke, and E. Vellenga Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma Blood, December 15, 2001; 98(13): 3849 - 3852. [Abstract] [Full Text] [PDF] G. Guasch, V. Ollendorff, J.-P. Borg, D. Birnbaum, and M.-J. Pebusque 8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways Mol. Cell. Biol., December 1, 2001; 21(23): 8129 - 8142. [Abstract] [Full Text] [PDF] J.-Z. Qin, C.-L. Zhang, J. Kamarashev, R. Dummer, G. Burg, and U. Dobbeling Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells Blood, November 1, 2001; 98(9): 2778 - 2783. [Abstract] [Full Text] [PDF] C. A. Fielding, K. Sandvej, A. Mehl, P. Brennan, M. Jones, and M. Rowe Epstein-Barr Virus LMP-1 Natural Sequence Variants Differ in Their Potential To Activate Cellular Signaling Pathways J. Virol., October 1, 2001; 75(19): 9129 - 9141. [Abstract] [Full Text] [PDF] M. G. Ferrari, E. D. Rivadeneira, R. Jarrett, L. Stevceva, S. Takemoto, P. Markham, and G. Franchini HVMNE, a novel lymphocryptovirus related to Epstein-Barr virus, induces lymphoma in New Zealand White rabbits Blood, October 1, 2001; 98(7): 2193 - 2199. [Abstract] [Full Text] [PDF] D. Kube, U. Holtick, M. Vockerodt, T. Ahmadi, B. Haier, I. Behrmann, P. C. Heinrich, V. Diehl, and H. Tesch STAT3 is constitutively activated in Hodgkin cell lines Blood, August 1, 2001; 98(3): 762 - 770. [Abstract] [Full Text] [PDF] S. Alas and B. Bonavida Rituximab Inactivates Signal Transducer and Activation of Transcription 3 (STAT3) Activity in B-Non-Hodgkin's Lymphoma through Inhibition of the Interleukin 10 Autocrine/Paracrine Loop and Results in Down-Regulation of Bcl-2 and Sensitization to Cytotoxic Drugs Cancer Res., July 1, 2001; 61(13): 5137 - 5144. [Abstract] [Full Text] [PDF] Z.-Q. Ning, J. Li, and R. J. Arceci Signal transducer and activator of transcription 3 activation is required for Asp816 mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells Blood, June 1, 2001; 97(11): 3559 - 3567. [Abstract] [Full Text] [PDF] G. Niu, K. H. Shain, M. Huang, R. Ravi, A. Bedi, W. S. Dalton, R. Jove, and H. Yu Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest Cancer Res., April 1, 2001; 61(8): 3276 - 3280. [Abstract] [Full Text] H. Chen, J. M. Lee, Y. Zong, M. Borowitz, M. H. Ng, R. F. Ambinder, and S. D. Hayward Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors J. Virol., March 15, 2001; 75(6): 2929 - 2937. [Abstract] [Full Text] C. L. Campbell, Z. Jiang, D. M. F. Savarese, and T. M. Savarese Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma Am. J. Pathol., January 1, 2001; 158(1): 25 - 32. [Abstract] [Full Text] [PDF] R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas Blood, November 15, 2000; 96(10): 3514 - 3521. [Abstract] [Full Text] [PDF] R. A. Kirken, R. A. Erwin, L. Wang, Y. Wang, H. Rui, and W. L. Farrar Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells J. Immunol., November 1, 2000; 165(9): 5097 - 5104. [Abstract] [Full Text] [PDF] J.-B. Demoulin, C. Uyttenhove, D. Lejeune, A. Mui, B. Groner, and J.-C. Renauld STAT5 Activation Is Required for Interleukin-9-dependent Growth and Transformation of Lymphoid Cells Cancer Res., July 1, 2000; 60(14): 3971 - 3977. [Abstract] [Full Text] Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation Mol. Cell. Biol., March 15, 2000; 20(6): 2043 - 2054. [Abstract] [Full Text] I. Grigorieva, V. G. Grigoriev, M. K. Rowney, and R. G. Hoover Regulation of c-myc Transcription by Interleukin-2 (IL-2). IDENTIFICATION OF A NOVEL IL-2 RESPONSE ELEMENT INTERACTING WITH STAT-4 J. Biol. Chem., March 15, 2000; 275(10): 7343 - 7350. [Abstract] [Full Text] [PDF] A. C. Ward, I. Touw, and A. Yoshimura The Jak-Stat pathway in normal and perturbed hematopoiesis Blood, January 1, 2000; 95(1): 19 - 29. [Full Text] [PDF] G. S. Foss and H. Prydz Interferon Regulatory Factor 1 Mediates the Interferon-gamma Induction of the Human Immunoproteasome Subunit Multicatalytic Endopeptidase Complex-like 1 J. Biol. Chem., December 3, 1999; 274(49): 35196 - 35202. [Abstract] [Full Text] [PDF] J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al. Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein Mol. Cell. Biol., November 1, 1999; 19(11): 7519 - 7528. [Abstract] [Full Text] [PDF] G. Niu, R. Heller, R. Catlett-Falcone, D. Coppola, M. Jaroszeski, W. Dalton, R. Jove, and H. Yu Gene Therapy with Dominant-negative Stat3 Suppresses Growth of the Murine Melanoma B16 Tumor in Vivo Cancer Res., October 1, 1999; 59(20): 5059 - 5063. [Abstract] [Full Text] [PDF] F. M. Uckun, O. Ek, X.-P. Liu, and C.-L. Chen In Vivo Toxicity and Pharmacokinetic Features of the Janus Kinase 3 Inhibitor WHI-P131 [4-(4'Hydroxyphenyl)-Amino-6,7-Dimethoxyquinazoline] Clin. Cancer Res., October 1, 1999; 5(10): 2954 - 2962. [Abstract] [Full Text] [PDF] E.D. Rivadeneira, M.G. Ferrari, R.F. Jarrett, A.A. Armstrong, P. Markham, T. Birkebak, S. Takemoto, C. Johnson-Delaney, J. Pecon-Slattery, E.A. Clark, et al. A Novel Epstein-Barr Virus-Like Virus, HVMNE, in a Macaca Nemestrina With Mycosis Fungoides Blood, September 15, 1999; 94(6): 2090 - 2101. [Abstract] [Full Text] [PDF] A. V. Kazansky, E. B. Kabotyanski, S. L. Wyszomierski, M. A. Mancini, and J. M. Rosen Differential Effects of Prolactin and src/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A J. Biol. Chem., August 6, 1999; 274(32): 22484 - 22492. [Abstract] [Full Text] [PDF] H. Chen, J. M. Lee, Y. Wang, D. P. Huang, R. F. Ambinder, and S. D. Hayward The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activity PNAS, August 3, 1999; 96(16): 9339 - 9344. [Abstract] [Full Text] [PDF] R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells Blood, August 1, 1999; 94(3): 1108 - 1112. [Abstract] [Full Text] [PDF] R. L. Ilaria Jr, R. G. Hawley, and R. A. Van Etten Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation Blood, June 15, 1999; 93(12): 4154 - 4166. [Abstract] [Full Text] [PDF] J. M.-Y. Ho, B. K. Beattie, J. A. Squire, D. A. Frank, and D. L. Barber Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling Blood, June 15, 1999; 93(12): 4354 - 4364. [Abstract] [Full Text] [PDF] H. Bao, S. M. Jacobs-Helber, A. E. Lawson, K. Penta, A. Wickrema, and S. T. Sawyer Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells) Blood, June 1, 1999; 93(11): 3757 - 3773. [Abstract] [Full Text] [PDF] T. C. Lund, P. C. Prator, M. M. Medveczky, and P. G. Medveczky The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells J. Virol., February 1, 1999; 73(2): 1689 - 1694. [Abstract] [Full Text] J.F. BROMBERG and J.E. DARNELL Jr. Potential Roles of Stat1 and Stat3 in Cellular Transformation Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 425 - 428. [Abstract] [PDF] C. S. Zong, L. Zeng, Y. Jiang, H. B. Sadowski, and L.-H. Wang Stat3 Plays an Important Role in Oncogenic Ros- and Insulin-like Growth Factor I Receptor-induced Anchorage-independent Growth J. Biol. Chem., October 23, 1998; 273(43): 28065 - 28072. [Abstract] [Full Text] [PDF] L. M.L. Tuyt, K. Bregman, C. Lummen, W. H.A. Dokter, and E. Vellenga Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells Blood, August 15, 1998; 92(4): 1364 - 1373. [Abstract] [Full Text] [PDF] K. Kirito, M. Uchida, M. Takatoku, K. Nakajima, T. Hirano, Y. Miura, and N. Komatsu A Novel Function of Stat1alpha and Stat3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line Blood, July 15, 1998; 92(2): 462 - 471. [Abstract] [Full Text] [PDF] M. Onishi, T. Nosaka, K. Misawa, A. L.-F. Mui, D. Gorman, M. McMahon, A. Miyajima, and T. Kitamura Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation Mol. Cell. Biol., July 1, 1998; 18(7): 3871 - 3879. [Abstract] [Full Text] J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation J. Virol., May 1, 1998; 72(5): 4408 - 4412. [Abstract] [Full Text] [PDF] J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation Mol. Cell. Biol., May 1, 1998; 18(5): 2545 - 2552. [Abstract] [Full Text] J. F. Bromberg, C. M. Horvath, D. Besser, W. W. Lathem, and J. E. Darnell Jr. Stat3 Activation Is Required for Cellular Transformation by v-src Mol. Cell. Biol., May 1, 1998; 18(5): 2553 - 2558. [Abstract] [Full Text] S. Takemoto, J. C. Mulloy, A. Cereseto, T.-S. Migone, B. K. R. Patel, M. Matsuoka, K. Yamaguchi, K. Takatsuki, S. Kamihira, J. D. White, et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins PNAS, December 9, 1997; 94(25): 13897 - 13902. [Abstract] [Full Text] [PDF] P. Saharinen, N. Ekman, K. Sarvas, P. Parker, K. Alitalo, and O. Silvennoinen The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cdelta Blood, December 1, 1997; 90(11): 4341 - 4353. [Abstract] [Full Text] [PDF] S. Priel-Halachmi, I. Ben-Dor, S. Shpungin, T. Tennenbaum, H. Molavani, M. Bachrach, S. Salzberg, and U. Nir FER Kinase Activation of Stat3 Is Determined by the N-terminal Sequence J. Biol. Chem., September 8, 2000; 275(37): 28902 - 28910. [Abstract] [Full Text] [PDF] P. Brennan, J. E. Floettmann, A. Mehl, M. Jones, and M. Rowe Mechanism of Action of a Novel Latent Membrane Protein-1 Dominant Negative J. Biol. Chem., January 5, 2001; 276(2): 1195 - 1203. [Abstract] [Full Text] [PDF] H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases J. Biol. Chem., December 22, 2000; 275(52): 41124 - 41132. [Abstract] [Full Text] [PDF] K. Ariyoshi, T. Nosaka, K. Yamada, M. Onishi, Y. Oka, A. Miyajima, and T. Kitamura Constitutive Activation of STAT5 by a Point Mutation in the SH2 Domain J. Biol. Chem., August 4, 2000; 275(32): 24407 - 24413. [Abstract] [Full Text] [PDF]

	Copyright © 1996 by American Society of Hematology         Online ISSN: 1528-0020