|
|
 Previous Article | Table of Contents | Next Article 
Involvement of transcription factor encoded by the mi locus in the
expression of c-kit receptor tyrosine kinase in cultured mast cells of mice
T Tsujimura, E Morii, M Nozaki, K Hashimoto, Y Moriyama, K Takebayashi, T Kondo, Y Kanakura and Y Kitamura
Department of Pathology, Medical School, Osaka University, Suita, Japan.
The mi locus of mice encodes a member of the basic-helix-loop-helix-
leucine zipper (bHLH-Zip) protein family of transcription factors
(hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs)
did not normally respond to stem cell factor (SCF), a ligand for the c-kit
receptor tyrosine kinase. The poor response of mi/mi CMCs to SCF was
attributed to the deficient expression of c-kit both the mRNA and protein
levels. The purpose of the present study is to investigate the effect of
MITF on the transcription of the c-kit gene. First, we introduced cDNA
encoding normal (+) MITF or mutant (mi) MITF into mi/mi CMCs using the
retroviral vector. Overexpression of (+)-MITF but not mi- MITF normalized
the expression of the c-kit and the poor response of mi/mi CMCs to SCF,
indicating the involvement of (+)-MITF in the c-kit gene transactivation.
Second, we analyzed the promoter of the c-kit gene. Three CANNTG motifs
recognized by bHLH-Zip-type transcription factors were conserved between
the mouse and human c-kit promoters. Among these three CANNTG motifs, only
the CACCTG motif (nt -356 to - 351) was specifically bound by (+)-MITF.
When the luciferase gene under the control of the c-kit promoter was
contransfected into NIH/3T3 fibroblasts with cDNA encoding (+)-MITF or
mi-MITF, the luciferase activity significantly increased only when (+)-MITF
cDNA was cotransfected. The deletion of the promoter region containing the
CACCTG motif or the mutation of the CACCTG to CTCCAG abolished the
transactivation effect of (+)-MITF, indicating that (+)-MITF transactivated
the c-kit gene through the CACCTG motif. When the luciferase gene under the
control of the c-kit promoter was introduced into the FMA3 mastocytoma and
FEC-P1 myeloid cell lines, remarkable luciferase activity was observed only
in FMA3 cells. Thus, the involvement of (+)-MITF in the c-kit
transactivation appeared to be specific to the mast cell lineage.
Volume 88,
Issue 4,
pp. 1225-1233,
08/15/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. Murase, A. Hachiya, Y. Amano, A. Ohuchi, T. Kitahara, and Y. Takema
The Essential Role of p53 in Hyperpigmentation of the Skin via Regulation of Paracrine Melanogenic Cytokine Receptor Signaling
J. Biol. Chem.,
February 13, 2009;
284(7):
4343 - 4353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhao, G. Gomez, S.-H. Yu, J. J. Ryan, and L. B. Schwartz
TGF-{beta}1 Attenuates Mediator Release and De Novo Kit Expression by Human Skin Mast Cells through a Smad-Dependent Pathway
J. Immunol.,
November 15, 2008;
181(10):
7263 - 7272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Carmi-Levy, N. Yannay-Cohen, G. Kay, E. Razin, and H. Nechushtan
Diadenosine Tetraphosphate Hydrolase Is Part of the Transcriptional Regulation Network in Immunologically Activated Mast Cells
Mol. Cell. Biol.,
September 15, 2008;
28(18):
5777 - 5784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Diwakar, D. Zhang, S. Jiang, and T. J. Hornyak
Neurofibromin as a regulator of melanocyte development and differentiation
J. Cell Sci.,
January 15, 2008;
121(2):
167 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Meadows, S. M. Sharma, G. J. Faulkner, M. C. Ostrowski, D. A. Hume, and A. I. Cassady
The Expression of Clcn7 and Ostm1 in Osteoclasts Is Coregulated by Microphthalmia Transcription Factor
J. Biol. Chem.,
January 19, 2007;
282(3):
1891 - 1904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. Shahlaee, S. Brandal, Y.-N. Lee, C. Jie, and C. M. Takemoto
Distinct and Shared Transcriptomes Are Regulated by Microphthalmia-Associated Transcription Factor Isoforms in Mast Cells
J. Immunol.,
January 1, 2007;
178(1):
378 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. R. Kataoka, N. Komazawa, E. Morii, K. Oboki, and T. Nakano
Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression
Blood,
February 1, 2005;
105(3):
1016 - 1020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Planque, G. Raposo, L. Leconte, O. Anezo, P. Martin, and S. Saule
Microphthalmia Transcription Factor Induces Both Retinal Pigmented Epithelium and Neural Crest Melanocytes from Neuroretina Cells
J. Biol. Chem.,
October 1, 2004;
279(40):
41911 - 41917.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, K. Oboki, K. Ishihara, T. Jippo, T. Hirano, and Y. Kitamura
Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments
Blood,
September 15, 2004;
104(6):
1656 - 1661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, A. Ito, T. Jippo, Y.-i. Koma, K. Oboki, T. Wakayama, S. Iseki, M. L. Lamoreux, and Y. Kitamura
Number of Mast Cells in the Peritoneal Cavity of Mice: Influence of Microphthalmia Transcription Factor through Transcription of Newly Found Mast Cell Adhesion Molecule, Spermatogenic Immunoglobulin Superfamily
Am. J. Pathol.,
August 1, 2004;
165(2):
491 - 499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Bejar, Y. Hong, and M. Schartl
Mitf expression is sufficient to direct differentiation of medaka blastula derived stem cells to melanocytes
Development,
December 29, 2003;
130(26):
6545 - 6553.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Funaba, T. Ikeda, M. Murakami, K. Ogawa, K. Tsuchida, H. Sugino, and M. Abe
Transcriptional Activation of Mouse Mast Cell Protease-7 by Activin and Transforming Growth Factor-{beta} Is Inhibited by Microphthalmia-associated Transcription Factor
J. Biol. Chem.,
December 26, 2003;
278(52):
52032 - 52041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pellegrini, P. Grimaldi, P. Rossi, R. Geremia, and S. Dolci
Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation
J. Cell Sci.,
August 15, 2003;
116(16):
3363 - 3372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Saito, K. Takeda, K.-i. Yasumoto, H. Ohtani, K.-i. Watanabe, K. Takahashi, A. Fukuzaki, Y. Arai, H. Yamamoto, and S. Shibahara
Germ Cell-Specific Expression of Microphthalmia-Associated Transcription Factor mRNA in Mouse Testis
J. Biochem.,
July 1, 2003;
134(1):
143 - 150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ito, T. Jippo, T. Wakayama, E. Morii, Y.-i. Koma, H. Onda, H. Nojima, S. Iseki, and Y. Kitamura
SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF
Blood,
April 1, 2003;
101(7):
2601 - 2608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, K. Oboki, T. Jippo, and Y. Kitamura
Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells
Blood,
February 15, 2003;
101(4):
1344 - 1350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Takemoto, Y.-J. Yoon, and D. E. Fisher
The Identification and Functional Characterization of a Novel Mast Cell Isoform of the Microphthalmia-associated Transcription Factor
J. Biol. Chem.,
August 9, 2002;
277(33):
30244 - 30252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, K. Oboki, T. R. Kataoka, K. Igarashi, and Y. Kitamura
Interaction and Cooperation of mi Transcription Factor (MITF) and Myc-associated Zinc-finger Protein-related Factor (MAZR) for Transcription of Mouse Mast Cell Protease 6 Gene
J. Biol. Chem.,
March 1, 2002;
277(10):
8566 - 8571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, H. Ogihara, K. Oboki, T. R. Kataoka, K. Maeyama, D. E. Fisher, M. L. Lamoreux, and Y. Kitamura
Effect of a large deletion of the basic domain of mi transcription factor on differentiation of mast cells
Blood,
October 15, 2001;
98(8):
2577 - 2579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, H. Ogihara, K. Oboki, C. Sawa, T. Sakuma, S. Nomura, J. D. Esko, H. Handa, and Y. Kitamura
Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells
Blood,
May 15, 2001;
97(10):
3032 - 3039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Morii, H. Ogihara, D.-K. Kim, A. Ito, K. Oboki, Y.-M. Lee, T. Jippo, S. Nomura, K. Maeyama, M. L. Lamoreux, et al.
Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mice/mice mutant mice of which MITF lacks the zipper domain
Blood,
April 1, 2001;
97(7):
2038 - 2044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ito, T. R. Kataoka, D.-K. Kim, Y.-i. Koma, Y.-M. Lee, and Y. Kitamura
Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice
Blood,
April 1, 2001;
97(7):
2075 - 2083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ogihara, E. Morii, D.-K. Kim, K. Oboki, and Y. Kitamura
Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene
Blood,
February 1, 2001;
97(3):
645 - 651.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Giannola, W. D. Shlomchik, M. Jegathesan, D. Liebowitz, C. S. Abrams, T. Kadesch, A. Dancis, and S. G. Emerson
Hematopoietic Expression of Hoxb4 Is Regulated in Normal and Leukemic Stem Cells through Transcriptional Activation of the Hoxb4 Promoter by Upstream Stimulating Factor (Usf)-1 and Usf-2
J. Exp. Med.,
November 20, 2000;
192(10):
1479 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Vitelli, G. Condorelli, V. Lulli, T. Hoang, L. Luchetti, C. M. Croce, and C. Peschle
A Pentamer Transcriptional Complex Including tal-1 and Retinoblastoma Protein Downmodulates c-kit Expression in Normal Erythroblasts
Mol. Cell. Biol.,
July 15, 2000;
20(14):
5330 - 5342.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Wu, T. J. Hemesath, C. M. Takemoto, M. A. Horstmann, A. G. Wells, E. R. Price, D. Z. Fisher, and D. E. Fisher
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
Genes & Dev.,
February 1, 2000;
14(3):
301 - 312.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Adachi, E. Morii, D.-k. Kim, H. Ogihara, T. Jippo, A. Ito, Y.-M. Lee, and Y. Kitamura
Involvement of mi-Transcription Factor in Expression of {alpha}-Melanocyte-Stimulating Hormone Receptor in Cultured Mast Cells of Mice
J. Immunol.,
January 15, 2000;
164(2):
855 - 860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Hou, J. Panthier, and H Arnheiter
Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF
Development,
January 12, 2000;
127(24):
5379 - 5389.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Roundy, A. Kollhoff, E. J. Eichwald, J. J. Weis, and J. H. Weis
Microphthalmic Mice Display a B Cell Deficiency Similar to that Seen for Mast and NK Cells
J. Immunol.,
December 15, 1999;
163(12):
6671 - 6678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-K. Kim, E. Morii, H. Ogihara, Y.-M. Lee, T. Jippo, S. Adachi, K. Maeyama, H.-M. Kim, and Y. Kitamura
Different Effect of Various Mutant MITF Encoded by mi, Mior, or Miwh Allele on Phenotype of Murine Mast Cells
Blood,
June 15, 1999;
93(12):
4179 - 4186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Jippo, Y.-M. Lee, Y. Katsu, K. Tsujino, E. Morii, D.-K. Kim, H.-M. Kim, and Y. Kitamura
Deficient Transcription of Mouse Mast Cell Protease 4 Gene in Mutant Mice of mi/mi Genotype
Blood,
March 15, 1999;
93(6):
1942 - 1950.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ito, E. Morii, D.-K. Kim, T. R. Kataoka, T. Jippo, K. Maeyama, H. Nojima, and Y. Kitamura
Inhibitory Effect of the Transcription Factor Encoded by the mi Mutant Allele in Cultured Mast Cells of Mice
Blood,
February 15, 1999;
93(4):
1189 - 1196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tsujimura, K. Hashimoto, H. Kitayama, H. Ikeda, H. Sugahara, I. Matsumura, T. Kaisho, N. Terada, Y. Kitamura, and Y. Kanakura
Activating Mutation in the Catalytic Domain of c-kit Elicits Hematopoietic Transformation by Receptor Self-Association Not at the Ligand-Induced Dimerization Site
Blood,
February 15, 1999;
93(4):
1319 - 1329.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lister, C. Robertson, T Lepage, S. Johnson, and D. Raible
nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
Development,
January 9, 1999;
126(17):
3757 - 3767.
[Abstract]
[PDF]
|
|
|
|
|
|
|
I. Aksan and C. R. Goding
Targeting the Microphthalmia Basic Helix-Loop-Helix-Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo
Mol. Cell. Biol.,
December 1, 1998;
18(12):
6930 - 6938.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. H. Park, H. K. Plummer III, and G. W. Krystal
Selective Sp1 Binding Is Critical for Maximal Activity of the Human c-kit Promoter
Blood,
December 1, 1998;
92(11):
4138 - 4149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-K. Kim, E. Morii, H. Ogihara, K. Hashimoto, K. Oritani, Y.-M. Lee, T. Jippo, S. Adachi, Y. Kanakura, and Y. Kitamura
Impaired Expression of Integrin alpha -4 Subunit in Cultured Mast Cells Derived From Mutant Mice of mi/mi Genotype
Blood,
September 15, 1998;
92(6):
1973 - 1980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Krosl, G. He, M. Lefrancois, F. Charron, P.-H. Romeo, P. Jolicoeur, I. R. Kirsch, M. Nemer, and T. Hoang
Transcription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells
J. Exp. Med.,
August 3, 1998;
188(3):
439 - 450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. R. Price, H.-F. Ding, T. Badalian, S. Bhattacharya, C. Takemoto, T.-P. Yao, T. J. Hemesath, and D. E. Fisher
Lineage-specific Signaling in Melanocytes. c-Kit STIMULATION RECRUITS p300/CBP TO MICROPHTHALMIA
J. Biol. Chem.,
July 17, 1998;
273(29):
17983 - 17986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ito, E. Morii, K. Maeyama, T. Jippo, D.-K. Kim, Y.-M. Lee, H. Ogihara, K. Hashimoto, Y. Kitamura, and H. Nojima
Systematic Method to Obtain Novel Genes That Are Regulated by mi Transcription Factor: Impaired Expression of Granzyme B and Tryptophan Hydroxylase in mi/mi Cultured Mast Cells
Blood,
May 1, 1998;
91(9):
3210 - 3221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Z. Ratajczak, D. Perrotti, P. Melotti, M. Powzaniuk, B. Calabretta, K. Onodera, D. A. Kregenow, B. Machalinski, and A. M. Gewirtz
Myb and Ets Proteins Are Candidate Regulators of c-kit Expression in Human Hematopoietic Cells
Blood,
March 15, 1998;
91(6):
1934 - 1946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. N. Weilbaecher, C. L. Hershey, C. M. Takemoto, M. A. Horstmann, T. J. Hemesath, A. H. Tashjian Jr., and D. E. Fisher
Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3
J. Exp. Med.,
March 2, 1998;
187(5):
775 - 785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Wakamatsu, M Mochii, K. Vogel, and J. Weston
Avian neural crest-derived neurogenic precursors undergo apoptosis on the lateral migration pathway
Development,
January 11, 1998;
125(21):
4205 - 4213.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Morii, T. Jippo, T. Tsujimura, K. Hashimoto, D.-K. Kim, Y.-M. Lee, H. Ogihara, K. Tsujino, H.-M. Kim, and Y. Kitamura
Abnormal Expression of Mouse Mast Cell Protease 5 Gene in Cultured Mast Cells Derived From Mutant mi/mi Mice
Blood,
October 15, 1997;
90(8):
3057 - 3066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Jippo, E. Morii, K. Tsujino, T. Tsujimura, Y.-M. Lee, D.-K. Kim, H. Matsuda, H.-M. Kim, and Y. Kitamura
Involvement of Transcription Factor Encoded by the Mouse mi Locus (MITF ) in Expression of p75 Receptor of Nerve Growth Factor in Cultured Mast Cells of Mice
Blood,
October 1, 1997;
90(7):
2601 - 2608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Nechushtan, Z. Zhang, and E. Razin
Microphthalmia (mi) in Murine Mast Cells: Regulation of Its Stimuli-Mediated Expression on the Translational Level
Blood,
April 15, 1997;
89(8):
2999 - 3008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Opdecamp, A Nakayama, M. Nguyen, C. Hodgkinson, W. Pavan, and H Arnheiter
Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor
Development,
January 6, 1997;
124(12):
2377 - 2386.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Imokawa, T. Kobayasi, and M. Miyagishi
Intracellular Signaling Mechanisms Leading to Synergistic Effects of Endothelin-1 and Stem Cell Factor on Proliferation of Cultured Human Melanocytes. CROSS-TALK VIA TRANS-ACTIVATION OF THE TYROSINE KINASE c-KIT RECEPTOR
J. Biol. Chem.,
October 20, 2000;
275(43):
33321 - 33328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
