|
|
 Previous Article | Table of Contents | Next Article 
p53 functional impairment and high p21waf1/cip1 expression in human T- cell
lymphotropic/leukemia virus type I-transformed T cells
A Cereseto, F Diella, JC Mulloy, A Cara, P Michieli, R Grassmann, G Franchini and ME Klotman
Laboratory of Tumor Cell Biology, National Cancer Institute, National
Institutes of Health, Bethesda, MD 20892-4255, USA.
Human T-cell lymphotropic/leukemia virus type I (HTLV-I) is associated with
T-cell transformation both in vivo and in vitro. Although some of the
mechanisms responsible for transformation remain unknown, increasing
evidence supports a direct role of viral as well as dysregulated cellular
proteins in transformation. We investigated the potential role of the tumor
suppressor gene p53 and of the p53- regulated gene, p21waf1/cip1 (wild-type
p53 activated fragment 1/cycling dependent kinases [cdks] interacting
protein 1), in HTLV-I- infected T cells. We have found that the majority of
HTLV-I-infected T cells have the wild-type p53 gene. However, its function
in HTLV-I- transformed cells appears to be impaired, as shown by the lack
of appropriate p53-mediated responses to ionizing radiation (IR).
Interestingly, the expression of the p53 inducible gene, p21waf1/cip1, is
elevated at the messenger ribonucleic acid and protein levels in all
HTLV-I-infected T-cell lines examined as well as in Taxl-1, a human T- cell
line stably expressing Tax. Additionally, Tax induces upregulation of a
p21waf1/cip1 promoter-driven luciferase gene in p53 null cells, and
increases p21waf1/cip1 expression in Jurkat T cells. These findings suggest
that the Tax protein is at least partially responsible for the
p53-independent expression of p21waf1/cip1 in HTLV-I-infected cells.
Dysregulation of p53 and p21waf1/cip1 proteins regulating cell-cycle
progression, may represent an important step in HTLV-I-induced T-cell
transformation.
Volume 88,
Issue 5,
pp. 1551-1560,
09/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Moarbess, H. El-Hajj, Y. Kfoury, M. E. El-Sabban, Y. Lepelletier, O. Hermine, C. Deleuze-Masquefa, P.-A. Bonnet, and A. Bazarbachi
EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma
Blood,
April 1, 2008;
111(7):
3770 - 3777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dasgupta, K.-J. Jung, S.-J. Jeong, and J. N. Brady
Inhibition of Methyltransferases Results in Induction of G2/M Checkpoint and Programmed Cell Death in Human T-Lymphotropic Virus Type 1-Transformed Cells
J. Virol.,
January 1, 2008;
82(1):
49 - 59.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-M. Mesnard, B. Barbeau, and C. Devaux
HBZ, a new important player in the mystery of adult T-cell leukemia
Blood,
December 15, 2006;
108(13):
3979 - 3982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Babu, M. Waterfield, M. Chang, X. Wu, and S.-C. Sun
Deregulated Activation of Oncoprotein Kinase Tpl2/Cot in HTLV-I-transformed T Cells
J. Biol. Chem.,
May 19, 2006;
281(20):
14041 - 14047.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Tabakin-Fix, I. Azran, Y. Schavinky-Khrapunsky, O. Levy, and M. Aboud
Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications
Carcinogenesis,
April 1, 2006;
27(4):
673 - 681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Murata, T. Hayashibara, K. Sugahara, A. Uemura, T. Yamaguchi, H. Harasawa, H. Hasegawa, K. Tsuruda, T. Okazaki, T. Koji, et al.
A Novel Alternative Splicing Isoform of Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ-SI) Targets Distinct Subnuclear Localization
J. Virol.,
March 1, 2006;
80(5):
2495 - 2505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Watanabe, T. Ohsugi, M. Shoda, T. Ishida, S. Aizawa, M. Maruyama-Nagai, A. Utsunomiya, S. Koga, Y. Yamada, S. Kamihira, et al.
Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-{kappa}B, as a strategy for chemoprevention and therapy of adult T-cell leukemia
Blood,
October 1, 2005;
106(7):
2462 - 2471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Awasthi, A. Sharma, K. Wong, J. Zhang, E. F. Matlock, L. Rogers, P. Motloch, S. Takemoto, H. Taguchi, M. D. Cole, et al.
A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions
Mol. Cell. Biol.,
July 15, 2005;
25(14):
6178 - 6198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-M. Peloponese Jr., H. Iha, V. R. K. Yedavalli, A. Miyazato, Y. Li, K. Haller, M. Benkirane, and K.-T. Jeang
Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity
J. Virol.,
November 1, 2004;
78(21):
11686 - 11695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sieburg, A. Tripp, J.-W. Ma, and G. Feuer
Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Tax Oncoproteins Modulate Cell Cycle Progression and Apoptosis
J. Virol.,
October 1, 2004;
78(19):
10399 - 10409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-J. Jeong, M. Radonovich, J. N. Brady, and C. A. Pise-Masison
HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity
Blood,
September 1, 2004;
104(5):
1490 - 1497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mori, T. Matsuda, M. Tadano, T. Kinjo, Y. Yamada, K. Tsukasaki, S. Ikeda, Y. Yamasaki, Y. Tanaka, T. Ohta, et al.
Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells
J. Virol.,
May 1, 2004;
78(9):
4582 - 4590.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tripp, Y. Liu, M. Sieburg, J. Montalbano, S. Wrzesinski, and G. Feuer
Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+ Cells In Vitro
J. Virol.,
November 15, 2003;
77(22):
12152 - 12164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Haoudi, R. C. Daniels, E. Wong, G. Kupfer, and O. J. Semmes
Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response
J. Biol. Chem.,
September 26, 2003;
278(39):
37736 - 37744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kawata, Y. Ariumi, and K. Shimotohno
p21Waf1/Cip1/Sdi1 Prevents Apoptosis as Well as Stimulates Growth in Cells Transformed or Immortalized by Human T-Cell Leukemia Virus Type 1-Encoded Tax
J. Virol.,
July 1, 2003;
77(13):
7291 - 7299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. H. Chowdhury, M. Radonovich, R. Mahieux, C. Pise-Masison, S. Muralidhar, and J. N. Brady
p53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway
J. Gen. Virol.,
April 1, 2003;
84(4):
897 - 906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Haller, Y. Wu, E. Derow, I. Schmitt, K.-T. Jeang, and R. Grassmann
Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein
Mol. Cell. Biol.,
May 15, 2002;
22(10):
3327 - 3338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Livengood, K. E. S. Scoggin, K. Van Orden, S. J. McBryant, R. S. Edayathumangalam, P. J. Laybourn, and J. K. Nyborg
p53 Transcriptional Activity Is Mediated through the SRC1-interacting Domain of CBP/p300
J. Biol. Chem.,
March 8, 2002;
277(11):
9054 - 9061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Imaizumi, S. Sugita, K. Yamamoto, D. Imanishi, T. Kohno, M. Tomonaga, and T. Matsuyama
Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3{alpha}/CCL20 gene transcription via the NF-{kappa}B pathway
Int. Immunol.,
February 1, 2002;
14(2):
147 - 155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ruckes, D. Saul, J. Van Snick, O. Hermine, and R. Grassmann
Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309
Blood,
August 15, 2001;
98(4):
1150 - 1159.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Portis, W. J. Grossman, J. C. Harding, J. L. Hess, and L. Ratner
Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model
J. Virol.,
March 1, 2001;
75(5):
2185 - 2193.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. de la Fuente, F. Santiago, S. Y. Chong, L. Deng, T. Mayhood, P. Fu, D. Stein, T. Denny, F. Coffman, N. Azimi, et al.
Overexpression of p21waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2
J. Virol.,
August 15, 2000;
74(16):
7270 - 7283.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. Mahieux, C. A. Pise-Masison, P. F. Lambert, C. Nicot, L. De Marchis, A. Gessain, P. Green, W. Hall, and J. N. Brady
Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function
J. Virol.,
August 1, 2000;
74(15):
6866 - 6874.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. A. Giebler, I. Lemasson, and J. K. Nyborg
p53 Recruitment of CREB Binding Protein Mediated through Phosphorylated CREB: a Novel Pathway of Tumor Suppressor Regulation
Mol. Cell. Biol.,
July 1, 2000;
20(13):
4849 - 4858.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Nicot, R. Mahieux, S. Takemoto, and G. Franchini
Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples
Blood,
July 1, 2000;
96(1):
275 - 281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Takemoto, R. Trovato, A. Cereseto, C. Nicot, T. Kislyakova, L. Casareto, T. Waldmann, G. Torelli, and G. Franchini
p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14ARF-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells
Blood,
June 15, 2000;
95(12):
3939 - 3944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Harrod, Y.-L. Kuo, Y. Tang, Y. Yao, A. Vassilev, Y. Nakatani, and C.-Z. Giam
p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex
J. Biol. Chem.,
April 14, 2000;
275(16):
11852 - 11857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Van Orden, H. A. Giebler, I. Lemasson, M. Gonzales, and J. K. Nyborg
Binding of p53 to the KIX Domain of CREB Binding Protein. A POTENTIAL LINK TO HUMAN T-CELL LEUKEMIA VIRUS, TYPE I-ASSOCIATED LEUKEMOGENESIS
J. Biol. Chem.,
September 10, 1999;
274(37):
26321 - 26328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Dierov, B. E. Sawaya, M. Prosniak, and R. B. Gartenhaus
Retinoic Acid Modulates a Bimodal Effect on Cell Cycle Progression in Human Adult T-Cell Leukemia Cells
Clin. Cancer Res.,
September 1, 1999;
5(9):
2540 - 2547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Cereseto, T Kislyakova, R. Parks, C Nicot, and G Franchini
Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells
J. Gen. Virol.,
July 1, 1999;
80(7):
1575 - 1581.
[Abstract]
|
|
|
|
|
|
|
P. Hollsberg
Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I
Microbiol. Mol. Biol. Rev.,
June 1, 1999;
63(2):
308 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Mulloy, T. Kislyakova, A. Cereseto, L. Casareto, A. LoMonico, J. Fullen, M. V. Lorenzi, A. Cara, C. Nicot, C.-Z. Giam, et al.
Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain
J. Virol.,
November 1, 1998;
72(11):
8852 - 8860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Uhlik, L. Good, G. Xiao, E. W. Harhaj, E. Zandi, M. Karin, and S.-C. Sun
NF-kappa B-inducing Kinase and Ikappa B Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-kappa B Activation
J. Biol. Chem.,
August 14, 1998;
273(33):
21132 - 21136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Pise-Masison, M. Radonovich, K. Sakaguchi, E. Appella, and J. N. Brady
Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells
J. Virol.,
August 1, 1998;
72(8):
6348 - 6355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini
Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation
J. Virol.,
May 1, 1998;
72(5):
4408 - 4412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Pise-Masison, K.-S. Choi, M. Radonovich, J. Dittmer, S.-J. Kim, and J. N. Brady
Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein
J. Virol.,
February 1, 1998;
72(2):
1165 - 1170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mori, F. Kashanchi, and D. Prager
Repression of Transcription From the Human T-Cell Leukemia Virus Type I Long Terminal Repeat and Cellular Gene Promoters by Wild-Type p53
Blood,
December 15, 1997;
90(12):
4924 - 4932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Rivera-Walsh, M. Waterfield, G. Xiao, A. Fong, and S.-C. Sun
NF-kappa B Signaling Pathway Governs TRAIL Gene Expression and Human T-cell Leukemia Virus-I Tax-induced T-cell Death
J. Biol. Chem.,
October 26, 2001;
276(44):
40385 - 40388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-Y. Kao, F. J. Lemoine, and S. J. Marriott
Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway
J. Biol. Chem.,
November 10, 2000;
275(46):
35926 - 35931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Pise-Masison, R. Mahieux, M. Radonovich, H. Jiang, and J. N. Brady
Human T-lymphotropic Virus Type I Tax Protein Utilizes Distinct Pathways for p53 Inhibition That Are Cell Type-dependent
J. Biol. Chem.,
January 5, 2001;
276(1):
200 - 205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Lemasson and J. K. Nyborg
Human T-cell Leukemia Virus Type I Tax Repression of p73beta Is Mediated through Competition for the C/H1 Domain of CBP
J. Biol. Chem.,
May 4, 2001;
276(19):
15720 - 15727.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Lemoine and S. J. Marriott
Accelerated G1 Phase Progression Induced by the Human T Cell Leukemia Virus Type I (HTLV-I) Tax Oncoprotein
J. Biol. Chem.,
August 17, 2001;
276(34):
31851 - 31857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
