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Shiga-like toxin purges human lymphoma from bone marrow of severe combined
immunodeficient mice
EC LaCasse, MT Saleh, B Patterson, MD Minden and J Gariepy
Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Shiga-like toxin-1 (SLT-1) is a bacterial toxin that kills cells by
inhibiting protein synthesis. SLT-1 is composed of one cytotoxic A- subunit
and five B-subunits that bind to CD77, a cell-surface glycolipid. In the
human hematopoietic system, CD77 expression is restricted to a subset of
activated B cells and derived cancers. Here we report that SLT-1 treatment
of murine bone marrow ex vivo effectively cures severe combined
immunodeficient mice of a human B- cell lymphoma xenograft while sparing
normal hematopoietic precursor cells. Flow cytometry results using
fluorescein isothiocyanate-labeled SLT-1 B-subunit show the high prevalence
of expression of SLT-1 receptors (CD77) in human non-Hodgkin's lymphomas,
especially follicular lymphomas. These results suggest the use of SLT-1 for
the purging of human bone marrow before autologous bone marrow transplant
in the case of CD77+ B-cell lymphomas as just one of many possible uses.
Volume 88,
Issue 5,
pp. 1561-1567,
09/01/1996
Copyright © 1996 by The American Society of Hematology
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