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Activation of the CD95 (APO-1/Fas) system in T cells from human
immunodeficiency virus type-1-infected children
CB Baumler, T Bohler, I Herr, A Benner, PH Krammer and KM Debatin
Department of Hematology/Oncology, University Children's Hospital,
Heidelberg, Germany.
Increased apoptosis of CD4+ T cells is considered to be involved in CD4+
T-cell depletion in human immunodeficiency virus type-1 (HIV-1)- infected
individuals progressing toward acquired immunodeficiency syndrome (AIDS).
We have recently shown that CD95 (APO-1/Fas) expression is strongly
increased in T cells of HIV-1-infected children. In this report we provide
further evidence for a deregulated CD95 system in AIDS. CD95 expression in
HIV-1+ children is not restricted to previously activated CD45RO+ T cells
but is also increased on freshly isolated naive CD45RA+ T cells. In
addition, specific CD95-mediated apoptosis is enhanced in both CD4+ and
CD8+ T cells. Furthermore, levels of CD95 ligand mRNA are profoundly
increased. Specific T-cell receptor/CD3-triggered apoptosis in HIV-1+
children is more enhanced in CD8+ than in CD4+ T cells. Accelerated
activation induced cell death of T cells could partially be inhibited by
blocking anti-CD95 antibody fragments. These data suggest an involvement of
the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS
and may open new avenues of rational intervention strategies.
Volume 88,
Issue 5,
pp. 1741-1746,
09/01/1996
Copyright © 1996 by The American Society of Hematology
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