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CD73 mediates adhesion of B cells to follicular dendritic cells
L Airas and S Jalkanen
National Public Health Institute, Turku University, Finland.
Lymphocyte-vascular adhesion protein-2 was recently identified as CD73. The
CD73 molecule, otherwise known as ecto-5'-nucleotidase, is a lymphocyte
maturation marker that is involved in intracellular signaling, and
lymphocyte proliferation and activation. We now show that CD73, in addition
to mediating lymphocyte binding to endothelial cells, also mediates
adhesion between B cells and follicular dendritic cells (FDC), as a
monoclonal antibody (MoAb) against CD73 inhibited the aggregation of
isolated germinal center B cells and FDC in vitro. Cytocentrifuge
preparations of isolated germinal center cells and two- color
immunofluorescence stainings of different tonsillar B-cell populations show
that CD73 is expressed on FDC and on small, recirculating IgD+ B cells, but
only on a few B cells inside the germinal center. Thus, we propose that
CD73 on FDC has an important role in controlling B cell-FDC interactions
and B-cell maturation in germinal centers.
Volume 88,
Issue 5,
pp. 1755-1764,
09/01/1996
Copyright © 1996 by The American Society of Hematology
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