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Cytogenetic and molecular delineation of a region of chromosome 7 commonly
deleted in malignant myeloid diseases
MM Beau, R Espinosa , EM Davis, JD Eisenbart, RA Larson and ED Green
Section of Hematology/Oncology, University of Chicago, IL 60637, USA.
Loss of a whole chromosome 7 or a deletion of the long arm, del(7q), are
recurring abnormalities in malignant myeloid diseases. To determine the
location of genes on 7q that are likely to play a role in leukemogenesis,
we examined the deleted chromosome 7 homologs in a series of 81 patients
with therapy-related or de novo myelodysplastic syndrome or acute myeloid
leukemia. Our analysis showed that the deletions were interstitial and that
there were two distinct deleted segments of 7q. The majority of patients
(65 of 81 [80%]) had proximal breakpoints in bands q11-22 and distal
breakpoints in q31-36; the smallest overlapping deleted segment was within
q22. The remaining 16 patients had deletions involving the distal q arm
with a commonly deleted segment of q32-33. To define the proximal deleted
segment at 7q22 at a molecular level, we used fluorescence in situ
hybridization with a panel of mapped yeast artificial chromosome (YAC)
clones from 7q to examine 15 patients with deletion breakpoints in 7q22. We
determined that the smallest overlapping deleted segment is contained in a
well- defined YAC contig that spans 2 to 3 Mb. These studies delineate the
region of 7q that must be searched to isolate a putative myeloid leukemia
suppressor gene, and provide the necessary cloned DNA for more detailed
physical mapping and gene isolation.
Volume 88,
Issue 6,
pp. 1930-1935,
09/15/1996
Copyright © 1996 by The American Society of Hematology
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