|
|
 Previous Article | Table of Contents | Next Article 
Relapse of hairy cell leukemia after 2-chlorodeoxyadenosine: long-term
follow-up of the Northwestern University experience
MS Tallman, D Hakimian, AW Rademaker, C Zanzig, E Wollins, E Rose and LC Peterson
Department of Medicine, Northwestern University Medical School, Robert H.
Lurie Cancer Center of Northwestern University, Chicago, IL 60611, USA.
Although 2-chlorodeoxyadenosine (2-CdA) is effective in inducing complete
remissions (CRs) in the majority of patients with hairy cell leukemia
(HCL), neither the actual relapse rate, the clinical factors that may
predict relapse, the long-term outcome, nor the response rate to
re-treatment at relapse has been clearly determined. Fifty-two consecutive
patients with previously untreated or treated HCL were treated with 2-CdA
at a dose of 0.1 mg/kg/d by continuous intravenous infusion for 7 days. Of
50 assessable patients, 40 (80%) achieved CR, and 9 (18%) achieved partial
remission (PR). A total of 7 patients (14%) have relapsed, at a median
duration of 24 months (range, 12 to 44). Of the 7 relapsed patients, 5 were
re-treated with a second cycle of 2-CdA; 2 achieved a second CR and 3
attained a PR. The progression- free survival (PFS) rate is 72% at 4 years
for all 52 patients and 83% for patients achieving CR. The overall survival
(OS) rate is 86% at 4 years. Only prior therapy was predictive of relapse.
The majority of patients achieve durable CRs with a single cycle of 2-CdA.
The relapse rate is low and the long-term prognosis is excellent. The few
patients who relapse can attain second remissions after re-treatment with
2-CdA.
Volume 88,
Issue 6,
pp. 1954-1959,
09/15/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. J. Kreitman, M. Stetler-Stevenson, I. Margulies, P. Noel, D. J.P. FitzGerald, W. H. Wilson, and I. Pastan
Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell Leukemia
J. Clin. Oncol.,
June 20, 2009;
27(18):
2983 - 2990.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Robak, K. Jamroziak, J. Gora-Tybor, J. Z. Blonski, M. Kasznicki, J. Dwilewicz-Trojaczek, E. Wiater, A. Zdunczyk, J. Dybowicz, A. Dmoszynska, et al.
Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial
Blood,
May 1, 2007;
109(9):
3672 - 3675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ravandi, J. L. Jorgensen, S. M. O'Brien, S. Verstovsek, C. A. Koller, S. Faderl, F. J. Giles, A. Ferrajoli, W. G. Wierda, S. Odinga, et al.
Eradication of minimal residual disease in hairy cell leukemia
Blood,
June 15, 2006;
107(12):
4658 - 4662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Arons, I. Margulies, L. Sorbara, M. Raffeld, M. Stetler-Stevenson, I. Pastan, and R. J. Kreitman
Minimal residual disease in hairy cell leukemia patients assessed by clone-specific polymerase chain reaction.
Clin. Cancer Res.,
May 1, 2006;
12(9):
2804 - 2811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ravandi and S. O'Brien
Chronic Lymphoid Leukemias Other Than Chronic Lymphocytic Leukemia: Diagnosis and Treatment
Mayo Clin. Proc.,
December 1, 2005;
80(12):
1660 - 1674.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Chadha, A. W. Rademaker, P. Mendiratta, B. Kim, D. M. Evanchuk, D. Hakimian, L. C. Peterson, and M. S. Tallman
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience
Blood,
July 1, 2005;
106(1):
241 - 246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Thomas, S. O'Brien, C. Bueso-Ramos, S. Faderl, M. J. Keating, F. J. Giles, J. Cortes, and H. M. Kantarjian
Rituximab in relapsed or refractory hairy cell leukemia
Blood,
December 1, 2003;
102(12):
3906 - 3911.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Goodman, C. Burian, J. A. Koziol, and A. Saven
Extended Follow-Up of Patients With Hairy Cell Leukemia After Treatment With Cladribine
J. Clin. Oncol.,
March 1, 2003;
21(5):
891 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. von Rohr, S.-F. H. Schmitz, A. Tichelli, U. Hess, D. Piguet, M. Wernli, N. Frickhofen, G. Konwalinka, G. Zulian, M. Ghielmini, et al.
Treatment of hairy cell leukemia with cladribine (2-chlorodeoxyadenosine) by subcutaneous bolus injection: a phase II study
Ann. Onc.,
October 1, 2002;
13(10):
1641 - 1649.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Federico, P. L. Zinzani, A. Frassoldati, M. Vinceti, A. Mode, L. Annino, T. Chisesi, G. Pagnucco, R. Invernizzi, M. Spriano, et al.
Risk of Second Cancer in Patients With Hairy Cell Leukemia: Long-Term Follow-Up
J. Clin. Oncol.,
February 1, 2002;
20(3):
638 - 646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. W. Flinn, K. J. Kopecky, M. K. Foucar, D. Head, J. M. Bennett, R. Hutchison, W. Corbett, P. Cassileth, T. Habermann, H. Golomb, et al.
Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin
Blood,
November 1, 2000;
96(9):
2981 - 2986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Cheson, D. A. Vena, J. Barrett, and B. Freidlin
Second Malignancies as a Consequence of Nucleoside Analog Therapy for Chronic Lymphoid Leukemias
J. Clin. Oncol.,
August 1, 1999;
17(8):
2454 - 2454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Tallman, D. Hakimian, K. J. Kopecky, S. Wheaton, E. Wollins, K. Foucar, P. A. Cassileth, T. Habermann, M. Grever, J. M. Rowe, et al.
Minimal Residual Disease in Patients with Hairy Cell Leukemia in Complete Remission Treated with 2-Chlorodeoxyadenosine or 2'-Deoxycoformycin and Prediction of Early Relapse
Clin. Cancer Res.,
July 1, 1999;
5(7):
1665 - 1670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Saven, C. Burian, J. Adusumalli, and J. A. Koziol
Filgrastim for Cladribine-Induced Neutropenic Fever in Patients With Hairy Cell Leukemia
Blood,
April 15, 1999;
93(8):
2471 - 2477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Saven, C. Burian, J. A. Koziol, and L. D. Piro
Long-Term Follow-Up of Patients With Hairy Cell Leukemia After Cladribine Treatment
Blood,
September 15, 1998;
92(6):
1918 - 1926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K Morris, J. M Kolesar, and J. G Kuhn
Review : Purine nucleoside analogs: fludarabine, entostatin and cladribine: Part 3: cladribine
Journal of Oncology Pharmacy Practice,
June 1, 1997;
3(2):
94 - 109.
[PDF]
|
|
|
|
|
