|
|
 Previous Article | Table of Contents | Next Article 
Hematologic effects of flt3 ligand in vivo in mice
K Brasel, HJ McKenna, PJ Morrissey, K Charrier, AE Morris, CC Lee, DE Williams and SD Lyman
Immunex Corp, Seattle, WA 98101, USA.
We have investigated the effects of in vivo treatment with flt3 ligand (FL)
on murine hematopoiesis, including mobilization of progenitors into the
peripheral blood (PB). Mice were injected once daily with 10 micrograms
recombinant human FL for 15 days. On days 3, 5, 8, 10, 15, and 22, mice
were killed and analyzed for the number of leukocytes and colony-forming
units (CFU) in bone marrow (BM), spleen, and PB. Splenic and PB cellularity
increased with time in FL-treated mice. In the spleen, there was an
increase in B cells, myeloid cells, and nucleated erythroid cells; in the
PB, there was an increase in lymphocytes, granulocytes, and monocytic
cells. The maximal number of CFU in the BM was observed after 3 days of FL
treatment, giving 3.7- and 7.3-fold increases in CFU-granulocyte-macrophage
(CFU-GM) and CFU-granulocyte, erythrocyte, monocyte, megakaryocyte
(CFU-GEMM), respectively, compared with mouse serum albumin (MSA)-treated
controls. After 8 days of FL treatment, there was a maximal 123- and
108-fold increase in splenic CFU-GM and CFU-GEMM, respectively. The maximal
number CFU-GM and CFU- GEMM were seen in PB on day 10, with 537- and
585-fold increases, respectively. Burst-forming units-erythroid (BFU-E)
increased in the same time frame as those of CFU-GM and CFU-GEMM in BM,
spleen, and PB, although the magnitude was not as great. Primitive day-13
CFU-spleen (CFU-S) and phenotypically defined stem cells were also
mobilized into the PB of FL-treated mice with similar kinetics and
magnitude to that of CFU-GM and CFU-GEMM. We conclude from these studies
that FL, when administered as a single agent, is a potent mobilizer of
hematopoietic progenitors into the PB.
Volume 88,
Issue 6,
pp. 2004-2012,
09/15/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Auffray, D. K. Fogg, E. Narni-Mancinelli, B. Senechal, C. Trouillet, N. Saederup, J. Leemput, K. Bigot, L. Campisi, M. Abitbol, et al.
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
J. Exp. Med.,
March 16, 2009;
206(3):
595 - 606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Martin, S. Rankin, S. Pitchford, I. F. Charo, G. C. Furtado, and S. A. Lira
Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
Diabetes,
November 1, 2008;
57(11):
3025 - 3033.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sekine, K. Kataoka, Y. Fukuyama, Y. Adachi, J. Davydova, M. Yamamoto, R. Kobayashi, K. Fujihashi, H. Suzuki, D. T. Curiel, et al.
A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration
J. Immunol.,
June 15, 2008;
180(12):
8126 - 8134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Papenfuss, A. P. Kithcart, N. D. Powell, M. A. McClain, I. E. Gienapp, T. M. Shawler, and C. C. Whitacre
Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis
J. Leukoc. Biol.,
December 1, 2007;
82(6):
1510 - 1518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. von Wulffen, M. Steinmueller, S. Herold, L. M. Marsh, P. Bulau, W. Seeger, T. Welte, J. Lohmeyer, and U. A. Maus
Lung Dendritic Cells Elicited by Fms-like Tyrosin 3-Kinase Ligand Amplify the Lung Inflammatory Response to Lipopolysaccharide
Am. J. Respir. Crit. Care Med.,
November 1, 2007;
176(9):
892 - 901.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, P. Atmaca-Sonmez, C. L. Schanie, S. T. Ildstad, H. J. Kaplan, and V. Enzmann
Endogenous Bone Marrow Derived Cells Express Retinal Pigment Epithelium Cell Markers and Migrate to Focal Areas of RPE Damage
Invest. Ophthalmol. Vis. Sci.,
September 1, 2007;
48(9):
4321 - 4327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Buza-Vidas, M. Cheng, S. Duarte, H. Nozad, S. E. W. Jacobsen, and E. Sitnicka
Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
Blood,
July 1, 2007;
110(1):
424 - 432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Tussiwand, N. Onai, L. Mazzucchelli, and M. G. Manz
Inhibition of Natural Type I IFN-Producing and Dendritic Cell Development by a Small Molecule Receptor Tyrosine Kinase Inhibitor with Flt3 Affinity
J. Immunol.,
September 15, 2005;
175(6):
3674 - 3680.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Smyth, M. E. Wallace, S. L. Nutt, H. Yagita, D. I. Godfrey, and Y. Hayakawa
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
J. Exp. Med.,
June 20, 2005;
201(12):
1973 - 1985.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Franchini, H. Hefti, S. Vollstedt, B. Glanzmann, M. Riesen, M. Ackermann, P. Chaplin, K. Shortman, and M. Suter
Dendritic Cells from Mice Neonatally Vaccinated with Modified Vaccinia Virus Ankara Transfer Resistance against Herpes Simplex Virus Type I to Naive One-Week-Old Mice
J. Immunol.,
May 15, 2004;
172(10):
6304 - 6312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. C. O'Neill and H. L. Wilson
Limitations with in vitro production of dendritic cells using cytokines
J. Leukoc. Biol.,
April 1, 2004;
75(4):
600 - 603.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Velders, R. van Os, H. Hagoort, P. Verzaal, H. F. L. Guiot, I. J. D. Lindley, R. Willemze, G. Opdenakker, and W. E. Fibbe
Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization
Blood,
January 1, 2004;
103(1):
340 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wodnar-Filipowicz
Flt3 Ligand: Role in Control of Hematopoietic and Immune Functions of the Bone Marrow
Physiology,
December 1, 2003;
18(6):
247 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Karsunky, M. Merad, A. Cozzio, I. L. Weissman, and M. G. Manz
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
J. Exp. Med.,
July 21, 2003;
198(2):
305 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Toliver-Kinsky, C. Y. Lin, D. N. Herndon, and E. R. Sherwood
Stimulation of Hematopoiesis by the Fms-Like Tyrosine Kinase 3 Ligand Restores Bacterial Induction of Th1 Cytokines in Thermally Injured Mice
Infect. Immun.,
June 1, 2003;
71(6):
3058 - 3067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Manfra, S.-C. Chen, K. K. Jensen, J. S. Fine, M. T. Wiekowski, and S. A. Lira
Conditional Expression of Murine Flt3 Ligand Leads to Expansion of Multiple Dendritic Cell Subsets in Peripheral Blood and Tissues of Transgenic Mice
J. Immunol.,
March 15, 2003;
170(6):
2843 - 2852.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Siegel, D. Yeldell, D. M. Goldenberg, M. G. Stabin, R. B. Sparks, R. M. Sharkey, A. Brenner, and R. D. Blumenthal
Red Marrow Radiation Dose Adjustment Using Plasma FLT3-L Cytokine Levels: Improved Correlations Between Hematologic Toxicity and Bone Marrow Dose for Radioimmunotherapy Patients
J. Nucl. Med.,
January 1, 2003;
44(1):
67 - 76.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Weigel, N. Nath, P. A. Taylor, A. Panoskaltsis-Mortari, W. Chen, A. M. Krieg, K. Brasel, and B. R. Blazar
Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses
Blood,
December 1, 2002;
100(12):
4169 - 4176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Williamson, J. M. Bilsborough, and J. L. Viney
Regulation of Mucosal Dendritic Cell Function by Receptor Activator of NF-{kappa}B (RANK)/RANK Ligand Interactions: Impact on Tolerance Induction
J. Immunol.,
October 1, 2002;
169(7):
3606 - 3612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Gilliland and J. D. Griffin
The roles of FLT3 in hematopoiesis and leukemia
Blood,
August 13, 2002;
100(5):
1532 - 1542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Velders, J. F. M. Pruijt, P. Verzaal, R. van Os, Y. van Kooyk, C. G. Figdor, E.-J. F. M. de Kruijf, R. Willemze, and W. E. Fibbe
Enhancement of G-CSF-induced stem cell mobilization by antibodies against the beta 2 integrins LFA-1 and Mac-1
Blood,
June 17, 2002;
100(1):
327 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Steptoe, J. M. Ritchie, and L. C. Harrison
Increased Generation of Dendritic Cells from Myeloid Progenitors in Autoimmune-Prone Nonobese Diabetic Mice
J. Immunol.,
May 15, 2002;
168(10):
5032 - 5041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Blumenthal, A. Reising, E. Leon, and D. M. Goldenberg
Modulation of Marrow Proliferation and Chemosensitivity by Tumor-produced Cytokines from Syngeneic Pancreatic Tumor Lines
Clin. Cancer Res.,
May 1, 2002;
8(5):
1301 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Kelly, Q. Liu, J. L. Kutok, I. R. Williams, C. L. Boulton, and D. G. Gilliland
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
Blood,
January 1, 2002;
99(1):
310 - 318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Etchart, P.-O. Desmoulins, K. Chemin, C. Maliszewski, B. Dubois, F. Wild, and D. Kaiserlian
Dendritic Cells Recruitment and In Vivo Priming of CD8+ CTL Induced by a Single Topical or Transepithelial Immunization Via the Buccal Mucosa with Measles Virus Nucleoprotein
J. Immunol.,
July 1, 2001;
167(1):
384 - 391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Leuker, M. Labow, W. Muller, and N. Wagner
Neonatally Induced Inactivation of the Vascular Cell Adhesion Molecule 1 Gene Impairs B Cell Localization and T Cell-Dependent Humoral Immune Response
J. Exp. Med.,
March 19, 2001;
193(6):
755 - 768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Pawlowska, S. Hashino, H. McKenna, B. J. Weigel, P. A. Taylor, and B. R. Blazar
In vitro tumor-pulsed or in vivo Flt3 ligand-generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow-transplanted mice
Blood,
March 1, 2001;
97(5):
1474 - 1482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Maraskovsky, E. Daro, E. Roux, M. Teepe, C. R. Maliszewski, J. Hoek, D. Caron, M. E. Lebsack, and H. J. McKenna
In vivo generation of human dendritic cell subsets by Flt3 ligand
Blood,
August 1, 2000;
96(3):
878 - 884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Morelli, M. A. Antonysamy, T. Takayama, H. Hackstein, Z. Chen, S. Qian, N. B. Zurowski, and A. W. Thomson
Microchimerism, Donor Dendritic Cells, and Alloimmune Reactivity in Recipients of Flt3 Ligand-Mobilized Hemopoietic Cells: Modulation by Tacrolimus
J. Immunol.,
July 1, 2000;
165(1):
226 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mach, S. Gillessen, S. B. Wilson, C. Sheehan, M. Mihm, and G. Dranoff
Differences in Dendritic Cells Stimulated in Vivo by Tumors Engineered to Secrete Granulocyte-Macrophage Colony-stimulating Factor or Flt3-Ligand
Cancer Res.,
June 1, 2000;
60(12):
3239 - 3246.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. J. McKenna, K. L. Stocking, R. E. Miller, K. Brasel, T. De Smedt, E. Maraskovsky, C. R. Maliszewski, D. H. Lynch, J. Smith, B. Pulendran, et al.
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
Blood,
June 1, 2000;
95(11):
3489 - 3497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Liu, J. Poursine-Laurent, and D. C. Link
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF
Blood,
May 15, 2000;
95(10):
3025 - 3031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wang, S. E. Braun, G. Sonpavde, and K. Cornetta
Antileukemic Activity of Flt3 Ligand in Murine Leukemia
Cancer Res.,
April 1, 2000;
60(7):
1895 - 1900.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. P. Ciavarra, K. D. Somers, R. R. Brown, W. F. Glass, P. J. d. Consolvo, G. L. Wright, and P. F. Schellhammer
Flt3-Ligand Induces Transient Tumor Regression in an Ectopic Treatment Model of Major Histocompatibility Complex-negative Prostate Cancer
Cancer Res.,
April 1, 2000;
60(8):
2081 - 2084.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-C. Shih, M. C.-T. Hu, J. Hu, Y. Weng, P. J. Yazaki, J. Medeiros, and S. J. Forman
A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells
Blood,
March 15, 2000;
95(6):
1957 - 1966.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Williamson, G. M. Westrich, and J. L. Viney
Modulating Dendritic Cells to Optimize Mucosal Immunization Protocols
J. Immunol.,
October 1, 1999;
163(7):
3668 - 3675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. C. Dougall, M. Glaccum, K. Charrier, K. Rohrbach, K. Brasel, T. De Smedt, E. Daro, J. Smith, M. E. Tometsko, C. R. Maliszewski, et al.
RANK is essential for osteoclast and lymph node development
Genes & Dev.,
September 15, 1999;
13(18):
2412 - 2424.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. E. Ohm, M. R. Shurin, C. Esche, M. T. Lotze, D. P. Carbone, and D. I. Gabrilovich
Effect of Vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation In Vivo
J. Immunol.,
September 15, 1999;
163(6):
3260 - 3268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Williams, J. Klem, I. J. Puzanov, P. V. Sivakumar, M. Bennett, and V. Kumar
Differentiation of NK1.1+, Ly49+ NK Cells from flt3+ Multipotent Marrow Progenitor Cells
J. Immunol.,
September 1, 1999;
163(5):
2648 - 2656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Borges, R. E. Miller, J. Jones, K. Ariail, J. Whitmore, W. Fanslow, and D. H. Lynch
Synergistic Action of fms-Like Tyrosine Kinase 3 Ligand and CD40 Ligand in the Induction of Dendritic Cells and Generation of Antitumor Immunity In Vivo
J. Immunol.,
August 1, 1999;
163(3):
1289 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Wolf and L. R. Rohrschneider
Fiz1, a Novel Zinc Finger Protein Interacting with the Receptor Tyrosine Kinase Flt3
J. Biol. Chem.,
July 23, 1999;
274(30):
21478 - 21484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-M. Peron, C. Esche, V. M. Subbotin, C. Maliszewski, M. T. Lotze, and M. R. Shurin
FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells
J. Immunol.,
December 1, 1998;
161(11):
6164 - 6170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Neipp, T. Zorina, M. A. Domenick, B. G. Exner, and S. T. Ildstad
Effect of FLT3 Ligand and Granulocyte Colony-Stimulating Factor on Expansion and Mobilization of Facilitating Cells and Hematopoietic Stem Cells in Mice: Kinetics and Repopulating Potential
Blood,
November 1, 1998;
92(9):
3177 - 3188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Shaw, A. A. Maung, R. J. Steptoe, A. W. Thomson, and N. L. Vujanovic3
Expansion of Functional NK Cells in Multiple Tissue Compartments of Mice Treated with Flt3-Ligand: Implications for Anti-Cancer and Anti-Viral Therapy
J. Immunol.,
September 15, 1998;
161(6):
2817 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Hawley, A. Z.C. Fong, H. Griesser, S. D. Lyman, and R. G. Hawley
Leukemic Predisposition of Mice Transplanted With Gene-Modified Hematopoietic Precursors Expressing flt3 Ligand
Blood,
September 15, 1998;
92(6):
2003 - 2011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Kapp, M. Bhatia, D. Bonnet, B. Murdoch, and J. E. Dick
Treatment of Non-Obese Diabetic (NOD)/Severe-Combined Immunodeficient Mice (SCID) With flt3 Ligand and Interleukin-7 Impairs the B-Lineage Commitment of Repopulating Cells After Transplantation of Human Hematopoietic Cells
Blood,
September 15, 1998;
92(6):
2024 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gratwohl, L. John, H. Baldomero, J. Roth, A. Tichelli, C. Nissen, S.D. Lyman, and A. Wodnar-Filipowicz
FLT-3 Ligand Provides Hematopoietic Protection From Total Body Irradiation in Rabbits
Blood,
August 1, 1998;
92(3):
765 - 769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Antonysamy, R. J. Steptoe, A. Khanna, W. A. Rudert, V. M. Subbotin, and A. W. Thomson
Flt-3 Ligand Increases Microchimerism But Can Prevent the Therapeutic Effect of Donor Bone Marrow in Transiently Immunosuppressed Cardiac Allograft Recipients
J. Immunol.,
April 15, 1998;
160(8):
4106 - 4113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Lyman and S. E. W. Jacobsen
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Blood,
February 15, 1998;
91(4):
1101 - 1134.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Salomon, J. L. Cohen, C. Masurier, and D. Klatzmann
Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics
J. Immunol.,
January 15, 1998;
160(2):
708 - 717.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Brasel, H. J. McKenna, K. Charrier, P. J. Morrissey, D. E. Williams, and S. D. Lyman
Flt3 Ligand Synergizes With Granulocyte-Macrophage Colony-Stimulating Factor or Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Progenitor Cells Into the Peripheral Blood of Mice
Blood,
November 1, 1997;
90(9):
3781 - 3788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Liu, J. Poursine-Laurent, and D. C. Link
The Granulocyte Colony-Stimulating Factor Receptor Is Required for the Mobilization of Murine Hematopoietic Progenitors Into Peripheral Blood by Cyclophosphamide or Interleukin-8 But Not Flt-3 Ligand
Blood,
October 1, 1997;
90(7):
2522 - 2528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S.-C. Juan, I. K. McNiece, G. Van, D. Lacey, C. Hartley, P. McElroy, Y. Sun, J. Argento, D. Hill, X.-Q. Yan, et al.
Chronic Expression of Murine flt3 Ligand in Mice Results in Increased Circulating White Blood Cell Levels and Abnormal Cellular Infiltrates Associated With Splenic Fibrosis
Blood,
July 1, 1997;
90(1):
76 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Molineux, C. McCrea, X. Q. Yan, P. Kerzic, and I. McNiece
Flt-3 Ligand Synergizes With Granulocyte Colony-Stimulating Factor to Increase Neutrophil Numbers and to Mobilize Peripheral Blood Stem Cells With Long-Term Repopulating Potential
Blood,
June 1, 1997;
89(11):
3998 - 4004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sudo, C. Shimazaki, E. Ashihara, T. Kikuta, H. Hirai, T. Sumikuma, N. Yamagata, H. Goto, T. Inaba, N. Fujita, et al.
Synergistic Effect of FLT-3 Ligand on the Granulocyte Colony-Stimulating Factor-Induced Mobilization of Hematopoietic Stem Cells and Progenitor Cells Into Blood in Mice
Blood,
May 1, 1997;
89(9):
3186 - 3191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
