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Genomic structure, chromosomal localization, start of transcription, and
tissue expression of the human p40-phox, a new component of the
nicotinamide adenine dinucleotide phosphate-oxidase complex
S Zhan, N Vazquez, S Zhan, FB Wientjes, ML Budarf, E Schrock, T Ried, ED Green and SJ Chanock
Pediatric Branch, National Cancer Institute, National Institutes of Health,
Bethesda, MD 20892, USA.
p40-phox is a newly isolated cytosolic component of the nicotinamide
adenine dinucleotide phosphate (NADPH)-oxidase that copurifies with p67-
phox. Although its function is not well defined, preliminary evidence
indicates that it is a component of the cytosolic complex. We report the
characterization of the human p40-phox gene, which is single copy and spans
approximately 18 kb with 10 exons. Based on fluorescent in situ
hybridization (FISH) studies and analysis of somatic hybrid cell lines, the
chromosomal location of p40-phox is human chromosome 22q13.1. The start of
transcription has been mapped to bp -156. The expression of p40-phox
message is restricted to hematopoietic cells. In addition to identifying
the mRNA transcript on Northern blot analysis in cells known to express
components of the NADPH-oxidase, polymorphonuclear leukocytes, monocytes, B
lymphoblastoid cell lines, and eosinophils, p40-phox is also expressed in
two other cell types of white cell lineage, mast cells, and basophils. In
addition, the mRNA for p40-phox is expressed in megakaryocytic cells, but
not in erythroid cells.
Volume 88,
Issue 7,
pp. 2714-2721,
10/01/1996
Copyright © 1996 by The American Society of Hematology
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