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Human eosinophils express functional CD30 ligand and stimulate
proliferation of a Hodgkin's disease cell line
A Pinto, D Aldinucci, A Gloghini, V Zagonel, M Degan, S Improta, S Juzbasic, M Todesco, V Perin, V Gattei, F Herrmann, HJ Gruss and A Carbone
Leukemia Unit, Centro di Riferimento Oncologico, Aviano, Italy.
The presence of a prominent tissue eosinophilia represents a typical
histopathologic hallmark of Hodgkin's disease (HD). To evaluate the
putative role of eosinophils on tumor cell regulation in HD, we have
analyzed these cells for the functional expression of CD30 ligand (CD30L),
a surface molecule able to transduce CD30-mediated proliferation signals on
Hodgkin's (H) and Reed-Sternberg (RS) cells. The results demonstrate that
circulating and tissue eosinophils from normal donors and patients with HD
or hypereosinophilic syndrome (HES), display CD30L mRNA and express CD30L
protein, as shown by immunostaining with a specific monoclonal antibody
(M80) and with a biotinylated soluble CD30-Fc fusion protein. The surface
density of CD30L on eosinophils from HD and HES patients was remarkably
higher compared with healthy donors, probably reflecting a
cytokine-mediated upregulation in these pathologic conditions. Accordingly,
we provide evidence that cytokines regulating eosinophils proliferation and
activation, ie, interleukin-5 (IL-5), IL-3, and granulocyte-macrophage
colony-stimulating factor (GM-CSF), are able to enhance the cellular
density of CD30L on purified eosinophils from normal subjects. Finally, we
show that native CD30L on human eosinophils is a functionally active
surface structure able to transduce proliferative signals on CD30+ target
cells, including cultured H-RS cells. Our data suggest that eosinophils may
not merely represent innocent bystanders, but rather act as important
elements in the pathology of HD by contributing to the deregulated network
of CD30/CD30L-mediated interactive signals between H-RS cells and
surrounding reactive cells.
Volume 88,
Issue 9,
pp. 3299-3305,
11/01/1996
Copyright © 1996 by The American Society of Hematology
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