|
|
 Previous Article | Table of Contents | Next Article 
Platelet and fibrin deposition at the damaged vessel wall: cooperative
substrates for neutrophil adhesion under flow conditions
PH Kuijper, HI Gallardo Torres, JW Lammers, JJ Sixma, L Koenderman and JJ Zwaginga
Department of Haematology, University Hospital Utrecht, The Netherlands.
At sites of vessel wall damage, the primary hemostatic reaction involves
platelet and fibrin deposition. At these sites, circulating leukocytes
marginate and become activated. Adhered platelets can support leukocyte
localization; however, the role of fibrin in this respect is not known. We
studied the adhesion of human neutrophils (polymorphonuclear leukocytes
[PMNs]) to endothelial extracellular matrix (ECM)-bound fibrin and
platelets under flow conditions. ECM alone did not show PMN adhesion.
ECM-coated cover slips were perfused with plasma to form a surface-bound
fibrin network, and/or with whole blood to allow platelet adhesion.
Unstimulated PMNs adhered to fibrin at moderate shear stress (20 to 200
mPa). ECM-bound platelets induced rolling adhesion and allowed more PMNs to
adhere at higher shear (320 mPa). ECM coated with both platelets and fibrin
induced more static and shear-resistant PMN adhesion. PMN adhesion to
fibrin alone but not to platelet/fibrin surfaces was inhibited by soluble
fibrinogen. Adhesion to fibrin alone was inhibited by CD11b and CD18
blocking antibodies. Furthermore, fibrin formed under flow conditions
showed up to threefold higher PMN adhesion compared with fibrin formed
under static conditions, due to structural differences. These results
indicate that circulating PMNs adhere to fibrin in an integrin-dependent
manner at moderate shear stresses. However, at higher shear rates (> 200
mPa), additional mechanisms (ie, activated platelets) are necessary for an
interaction of PMNs with a fibrin network.
Volume 89,
Issue 1,
pp. 166-175,
01/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. Yang, S. Lang, Z. Zhai, L. Li, W. H. A. Kahr, P. Chen, J. Brkic, C. M. Spring, M. J. Flick, J. L. Degen, et al.
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
Blood,
July 9, 2009;
114(2):
425 - 436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Pluskota, N. M. Woody, D. Szpak, C. M. Ballantyne, D. A. Soloviev, D. I. Simon, and E. F. Plow
Expression, activation, and function of integrin {alpha}M{beta}2 (Mac-1) on neutrophil-derived microparticles
Blood,
September 15, 2008;
112(6):
2327 - 2335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. U. Eisenhardt, M. Schwarz, N. Schallner, J. Soosairajah, N. Bassler, D. Huang, C. Bode, and K. Peter
Generation of activation-specific human anti-{alpha}M{beta}2 single-chain antibodies as potential diagnostic tools and therapeutic agents
Blood,
April 15, 2007;
109(8):
3521 - 3528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. K. Lishko, T. Burke, and T. Ugarova
Antiadhesive effect of fibrinogen: a safeguard for thrombus stability
Blood,
February 15, 2007;
109(4):
1541 - 1549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Houard, A. Leclercq, V. Fontaine, M. Coutard, J.-L. Martin-Ventura, B. Ho-Tin-Noe, Z. Touat, O. Meilhac, and J.-B. Michel
Retention and Activation of Blood-Borne Proteases in the Arterial Wall: Implications for Atherothrombosis
J. Am. Coll. Cardiol.,
October 27, 2006;
48(9_Suppl_A):
A3 - A9.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.C. de Boer, C. Verseyden, L.H. Ulfman, J.J. Zwaginga, I. Bot, E.A. Biessen, T.J. Rabelink, and A.J. van Zonneveld
Fibrin and Activated Platelets Cooperatively Guide Stem Cells to a Vascular Injury and Promote Differentiation Towards an Endothelial Cell Phenotype
Arterioscler Thromb Vasc Biol,
July 1, 2006;
26(7):
1653 - 1659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Iwaki, M. J. Sandoval-Cooper, M. Brechmann, V. A. Ploplis, and F. J. Castellino
A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice
Blood,
May 15, 2006;
107(10):
3883 - 3891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Lu, Y. Chen, YinHuang, W. Li, and M. Jiang
Venous Hypertension Induces Increased Platelet Reactivity and Accumulation in Patients with Chronic Venous Insufficiency
Angiology,
May 1, 2006;
57(3):
321 - 329.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. Stratmann and D. Tschoepe
Pathobiology and cell interactions of platelets in diabetes
Diabetes and Vascular Disease Research,
February 1, 2005;
2(1):
16 - 23.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Chavakis, S. Santoso, K. J. Clemetson, U. J. H. Sachs, I. Isordia-Salas, R. A. Pixley, P. P. Nawroth, R. W. Colman, and K. T. Preissner
High Molecular Weight Kininogen Regulates Platelet-Leukocyte Interactions by Bridging Mac-1 and Glycoprotein Ib
J. Biol. Chem.,
November 14, 2003;
278(46):
45375 - 45381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Ulfman, D. P. H. Joosten, C. W. van Aalst, J.-W. J. Lammers, E. A. van de Graaf, L. Koenderman, and J. J. Zwaginga
Platelets Promote Eosinophil Adhesion of Patients with Asthma to Endothelium under Flow Conditions
Am. J. Respir. Cell Mol. Biol.,
April 1, 2003;
28(4):
512 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Santoso, U. J.H. Sachs, H. Kroll, M. Linder, A. Ruf, K. T. Preissner, and T. Chavakis
The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1
J. Exp. Med.,
September 2, 2002;
196(5):
679 - 691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Iwaki, M. J. Sandoval-Cooper, M. Paiva, T. Kobayashi, V. A. Ploplis, and F. J. Castellino
Fibrinogen Stabilizes Placental-Maternal Attachment During Embryonic Development in the Mouse
Am. J. Pathol.,
March 1, 2002;
160(3):
1021 - 1034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. K. Lishko, V. P. Yakubenko, K. M. Hertzberg, G. Grieninger, and T. P. Ugarova
The alternatively spliced {alpha}EC domain of human fibrinogen-420 is a novel ligand for leukocyte integrins {alpha}M{beta}2 and {alpha}X{beta}2
Blood,
October 15, 2001;
98(8):
2448 - 2455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-F. Theoret, J.-G. Bienvenu, A. Kumar, and Y. Merhi
P-Selectin Antagonism with Recombinant P-Selectin Glycoprotein Ligand-1 (rPSGL-Ig) Inhibits Circulating Activated Platelet Binding to Neutrophils Induced by Damaged Arterial Surfaces
J. Pharmacol. Exp. Ther.,
August 1, 2001;
298(2):
658 - 664.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. Forsyth, D. A. Solovjov, T. P. Ugarova, and E. F. Plow
Integrin {alpha}M{beta}2-Mediated Cell Migration to Fibrinogen and Its Recognition Peptides
J. Exp. Med.,
May 21, 2001;
193(10):
1123 - 1134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Li, H. Hu, M. Lindqvist, E. Wikstrom-Jonsson, A. H. Goodall, and P. Hjemdahl
Platelet-Leukocyte Cross Talk in Whole Blood
Arterioscler Thromb Vasc Biol,
December 1, 2000;
20(12):
2702 - 2708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. I. Simon, Z. Chen, H. Xu, C. Q. Li, J.-f. Dong, L. V. McIntire, C. M. Ballantyne, L. Zhang, M. I. Furman, M. C. Berndt, et al.
Platelet Glycoprotein Ib{alpha} Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)
J. Exp. Med.,
July 17, 2000;
192(2):
193 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Altman, J. Rouvier, and A. Scazziota
State-of-the-Art Review : Secondary Prevention of Myocardial Infarction: Beneficial Effect of Combining Oral Anticoagulant Plus Aspirin: Therapy Based on Evidence
Clinical and Applied Thrombosis/Hemostasis,
July 1, 2000;
6(3):
126 - 134.
[PDF]
|
|
|
|
|
|
|
G. Theilmeier, T. Lenaerts, C. Remacle, D. Collen, J. Vermylen, and M. F. Hoylaerts
Circulating Activated Platelets Assist THP-1 Monocytoid/Endothelial Cell Interaction Under Shear Stress
Blood,
October 15, 1999;
94(8):
2725 - 2734.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Brummel, S. Butenas, and K. G. Mann
An Integrated Study of Fibrinogen during Blood Coagulation
J. Biol. Chem.,
August 6, 1999;
274(32):
22862 - 22870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Ramos, Y. Huo, U. Jung, S. Ghosh, D. R. Manka, I. J. Sarembock, and K. Ley
Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice
Circ. Res.,
June 11, 1999;
84(11):
1237 - 1244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Zwaginga, H. I. G. Torres, J.-W. J. Lammers, J. J. Sixma, L. Koenderman, and P. H. M. Kuijper
Minimal Platelet Deposition and Activation in Models of Injured Vessel Wall Ensure Optimal Neutrophil Adhesion Under Flow Conditions
Arterioscler Thromb Vasc Biol,
June 1, 1999;
19(6):
1549 - 1554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Merhi, P. Provost, P. Chauvet, J.-F. Theoret, M. L. Phillips, and J.-G. Latour
Selectin Blockade Reduces Neutrophil Interaction With Platelets at the Site of Deep Arterial Injury by Angioplasty in Pigs
Arterioscler Thromb Vasc Biol,
February 1, 1999;
19(2):
372 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. H. Koo, K. I. Welsh, J. A. Roake, P. J. Morris, and S. V. Fuggle
Ischemia/Reperfusion Injury in Human Kidney Transplantation : An Immunohistochemical Analysis of Changes after Reperfusion
Am. J. Pathol.,
August 1, 1998;
153(2):
557 - 566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Sitrin, P. M. Pan, S. Srikanth, and R. F. Todd III
Fibrinogen Activates NF-{kappa}B Transcription Factors in Mononuclear Phagocytes
J. Immunol.,
August 1, 1998;
161(3):
1462 - 1470.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
