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Hemophilia and nonprogressing human immunodeficiency virus type 1 infection
E Vicenzi, P Bagnarelli, E Santagostino, S Ghezzi, M Alfano, MS Sinnone, G Fabio, L Turchetto, G Moretti, A Lazzarin, A Mantovani, PM Mannucci, M Clementi, A Gringeri and G Poli
DIBIT, Department of Infectious Diseases, San Raffaele Scientific
Institute, Milan, Italy.
Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1
(HIV-1) before 1986 through contaminated plasma products are currently
healthy, with CD4 T-cell counts above 500 cells/microL, and have never
received antiretroviral therapy (long-term nonprogressors [LTNPs]). Seven
age and sex-matched hemophiliacs infected in the same period but who have
progressive HIV disease (progressors) and one additional slow-progressing
individual were also studied. One hundred- fold, 20-fold, and 10-fold lower
levels of full-length HIV RNA in plasma, peripheral blood mononuclear cells
(PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs
compared with progressors. Plasma and cell-associated HIV RNA and proviral
DNA were lower in LTNPs who tested negative for viral isolation from PBMCs
or who were positive only after removal of CD8+ cells. No substantial
differences were observed in the in vitro production of chemokines
including RANTES, MIP- 1 alpha, MIP-1 beta, MCP-1, and interleukin-8 (IL-8)
in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even
when HIV isolation was simultaneously accomplished exclusively after
removal of CD8+ cells. Low levels of HIV load and replication in peripheral
blood are the strongest correlates of nonprogression in this small number
of infected hemophiliacs.
Volume 89,
Issue 1,
pp. 191-200,
01/01/1997
Copyright © 1997 by The American Society of Hematology
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