|
|
 Previous Article | Table of Contents | Next Article 
Tissue factor pathway inhibitor blocks cellular effects of endotoxin by
binding to endotoxin and interfering with transfer to CD14
CT Park, AA Creasey and SD Wright
Laboratory of Cellular Physiology and Immunology, The Rockefeller
University, New York, NY 10021, USA.
Tissue factor pathway inhibitor (TFPI) is a Kunitz-type plasma protease
inhibitor that inhibits factor Xa and the factor VIIa/tissue factor
catalytic complex. It plays an important role in feedback inhibition of the
coagulation cascade (Broze, Annu Rev Med 46:103, 1995). TFPI has also been
used successfully to prevent lethality and attenuate coagulopathic
responses in a baboon model of septic shock (Creasey et al, J Clin Invest
91:2850, 1993; and Carr et al, Circ Shock 44:126, 1995). However, the
mechanism of reduced mortality in these animals could not be explained
merely by the anticoagulant effect of TFPI, because TFPI-treated animals
also had a significantly depressed interleukin-6 response. Moreover,
inhibition of coagulopathic responses by other anticoagulants has failed to
block the organ damage or lethal effect of endotoxic shock (Coalson et al,
Circ Shock 5:423, 1978; Warr et al, Blood 75:1481, 1990; and Taylor et al,
Blood 78:364, 1991). We show here that recombinant TFPI can bind to
endotoxin in vitro. This binding prevents interaction of endotoxin with
both lipopolysaccharide binding protein and CD14, thereby blocking cellular
responses.
Volume 89,
Issue 12,
pp. 4268-4274,
06/15/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. Tang, L. Ivanciu, N. Popescu, G. Peer, E. Hack, C. Lupu, F. B. Taylor Jr, and F. Lupu
Sepsis-Induced Coagulation in the Baboon Lung Is Associated with Decreased Tissue Factor Pathway Inhibitor
Am. J. Pathol.,
September 1, 2007;
171(3):
1066 - 1077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Munford
Invited review: Detoxifying endotoxin: time, place and person
Innate Immunity,
April 1, 2005;
11(2):
69 - 84.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Levi, T. T Keller, E. van Gorp, and H. ten Cate
Infection and inflammation and the coagulation system
Cardiovasc Res,
October 15, 2003;
60(1):
26 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kato
Regulation of Functions of Vascular Wall Cells by Tissue Factor Pathway Inhibitor: Basic and Clinical Aspects
Arterioscler. Thromb. Vasc. Biol.,
April 1, 2002;
22(4):
539 - 548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Munford and J. Pugin
The crucial role of systemic responses in the innate (non-adaptive) host defense
Innate Immunity,
August 1, 2001;
7(4):
327 - 332.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Tapper and H. Herwald
Modulation of hemostatic mechanisms in bacterial infectious diseases
Blood,
October 1, 2000;
96(7):
2329 - 2337.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. de Jonge, P. E. P. Dekkers, A. A. Creasey, C. E. Hack, S. K. Paulson, A. Karim, J. Kesecioglu, M. Levi, S. J. H. van Deventer, and T. van der Poll
Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
Blood,
February 15, 2000;
95(4):
1124 - 1129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nieuwland, R. J. Berckmans, S. McGregor, A. N. Boing, F. P. H. Th. M. Romijn, R. G. J. Westendorp, C. E. Hack, and A. Sturk
Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
Blood,
February 1, 2000;
95(3):
930 - 935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Park and S. D. Wright
Fibrinogen is a component of a novel lipoprotein particle: Factor H-related protein (FHRP)-associated lipoprotein particle (FALP)
Blood,
January 1, 2000;
95(1):
198 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ding, N. Thieblemont, J. Zhu, F. Jin, J. Zhang, and S. Wright
Secretory Leukocyte Protease Inhibitor Interferes with Uptake of Lipopolysaccharide by Macrophages
Infect. Immun.,
September 1, 1999;
67(9):
4485 - 4489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kato
Regulation of Functions of Vascular Wall Cells by Tissue Factor Pathway Inhibitor: Basic and Clinical Aspects
Arterioscler. Thromb. Vasc. Biol.,
April 1, 2002;
22(4):
539 - 548.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
