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Expression of the T-cell activation antigen, OX-40, identifies alloreactive
T cells in acute graft-versus-host disease
TV Tittle, AD Weinberg, CN Steinkeler and RT Maziarz
Veterans Affairs Medical Center, Portland, OR, USA.
The OX-40 molecule is expressed on the surface of recently activated T
lymphocytes. The presence of OX-40 on CD4+ T cells was analyzed in a rat
haplo-identical (parental --> F1) bone marrow transplant model of acute
graft-versus-host disease (aGVHD). Increased numbers of activated CD4+ T
cells that expressed the OX-40 antigen were detected in peripheral blood
soon after transplantation before the earliest sign of disease. The peak of
OX-40 expression occurred 12 days posttransplantation with a range of 18%
to 36% of circulating T cells and remained 10-fold above background, never
returning to baseline. A slight increase in OX-40 expression (range, 1% to
6%) was also detected on peripheral blood lymphocytes from control
syngeneic F1 --> F1 recipients. OX-40+ T cells were isolated from
spleen, skin, lymph node, and liver tissue of rats undergoing aGVHD, but
not in syngeneic transplants. OX-40+ T cells isolated from these tissues
were of donor origin and were shown to be alloreactive. These data raise
the possibility of using the OX-40 antibody to detect and deplete
selectively the T cells that cause aGVHD.
Volume 89,
Issue 12,
pp. 4652-4658,
06/15/1997
Copyright © 1997 by The American Society of Hematology
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