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 Previous Article | Table of Contents | Next Article 
A single genetic origin for a common Caucasian risk factor for venous
thrombosis
A Zivelin, JH Griffin, X Xu, I Pabinger, M Samama, J Conard, B Brenner, A Eldor and U Seligsohn
Department of Hematology, Sheba Medical Center, Tel-Aviv University,
Israel.
A common genetic risk factor for venous thrombosis among Caucasoid
subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V
that replaces Arg506 with Gln and imparts resistance of factor Va to the
anticoagulant, activated protein C. Haplotype analyses using six dimorphic
sites in the factor V gene for 117 Caucasian subjects of Jewish, Arab,
Austrian, and French origin who were homozygous for nt A1691 compared with
167 controls (nt G1691) support a single origin for this polymorphism. The
nt G1691A mutation is estimated to have arisen circa 21,000 to 34,000 years
ago, ie, after the evolutionary divergence of Africans from non-Africans
and of Caucasoid from Mongoloid subpopulations.
Volume 89,
Issue 2,
pp. 397-402,
01/15/1997
Copyright © 1997 by The American Society of Hematology
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