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Upregulation of cortactin expression during the maturation of
megakaryocytes
X Zhan, CC Haudenschild, Y Ni, E Smith and C Huang
Department of Experimental Pathology, Jeremy H. Holland Laboratory,
American Red Cross, Rockville, MD 20855, USA.
Cortactin is a potent filamentous actin-binding protein acting as a
prominent substrate of Src tyrosine kinases. We have evaluated cortactin
expression in a series of murine tissues and shown an abundant expression
of cortactin in megakaryocytes and platelets. Cortactin, but not its
related protein HS1, is upregulated during the phorbol 12-myristate
13-acetate (PMA)-mediated maturation of a human megakaryoblastic cell line
CMK. Although the expression of Src-related kinases is also upregulated
more rapidly than cortactin in PMA-treated CMK cells, tyrosine
phosphorylation of cortactin appears to be only transiently elevated 4 days
after PMA stimulation. In addition, cortactin expression is induced by
thrombopoietin and interleukin-3 in megakaryocytes derived from murine bone
marrow cells. Thus, cortactin represents a megakaryocyte-specific gene in
bone marrow and the interaction of Src kinases with cortactin may be
involved in the maturation of megakaryocytes.
Volume 89,
Issue 2,
pp. 457-464,
01/15/1997
Copyright © 1997 by The American Society of Hematology
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