|
|
 Previous Article | Table of Contents | Next Article 
Primary non-Hodgkin's lymphoma of the intestine: high prevalence of
Epstein-Barr virus in Mexican lymphomas as compared with European cases
L Quintanilla-Martinez, C Lome-Maldonado, G Ott, A Gschwendtner, E Gredler, E Reyes, A Angeles-Angeles and F Fend
Department of Pathology, Instituto Nacional de la Nutricion, Mexico City.
Recent studies in Western European populations have shown that peripheral
T-cell non-Hodgkin's lymphomas (T-NHLs) are associated with Epstein-Barr
virus (EBV) in a higher percentage than sporadic B-cell NHL (B-NHLs), and
that the frequency of EBV-positivity might be influenced by the primary
site of the tumor. Because of the geographic differences in EBV expression
in Burkitt's lymphoma (BL) and Hodgkin's disease (HD), and the lack of
studies of sporadic NHL from developing countries, we decided to survey the
presence of EBV in a series of primary intestinal lymphomas from patients
in Mexico and in Western Europe, and to analyze whether EBV status is
influenced by tumor phenotype, and geographic or ethnic determinants.
Paraffin-embedded tissue from 43 primary intestinal NHLs (19 cases from
Mexico and 24 from Western Europe) were examined, including 17 high grade
B-NHLs, 9 low grade B-NHLs, and 17 T-NHLs; 6 of which were enteropathy
associated T-cell lymphomas. The distribution of histologic subtypes was
similar in both groups. The presence of EBV was investigated with a
combined approach using a nested polymerase chain reaction technique as
well as immunohistochemistry for latent membrane protein-1 and in situ
hybridization for EBV early RNA transcripts (EBER 1/2) RNAs. The median age
of the Mexican patients was significantly lower than the median age of the
European patients (32 v 62 years). This difference was most pronounced in
patients with T-cell lymphoma (24 v 63 years). EBER- positive tumor cells
were detected in 13 of the 43 (30%) cases of primary intestinal lymphoma,
including 5 of 26 sporadic B-NHL (3 high grade and 2 low grade), and 8 of
17 T-NHL, all of which were classified as pleomorphic, medium and large
cell. The rates of EBV-positivity were markedly different for European and
Mexican cases. Whereas 7 of 7 (100%) T-NHL and 5 of 12 (42%) sporadic B-NHL
of Mexican origin were EBER-positive, only 1 of 10 T-NHL and 0 of 14
sporadic B-NHL from Europe showed EBER expression in tumor cells. Latent
membrane protein was positive in only 2 of 43 cases, 1 of which was an
EBER-negative high grade B-NHL from Mexico that showed intact total mRNA in
control hybridization. CD30 expression was found in 4 of 8 EBV-positive
T-NHL and in none of the EBV-positive B-NHL. In contrast to European cases,
intestinal NHLs from Mexico show a very high frequency of EBV- positivity,
which is not limited to T-NHL, but includes a significant proportion of
B-NHL. This study strongly suggests that similar to HD and probably BL,
there are important epidemiologic differences in EBV association in
intestinal T-cell NHL between European and Mexican populations. These
differences might be the result of environmental factors, for example,
earlier contact with childhood viruses on intestinal lymphomagenesis.
Volume 89,
Issue 2,
pp. 644-651,
01/15/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. A. Rizvi, A. M. Evens, M. S. Tallman, B. P. Nelson, and S. T. Rosen
T-cell non-Hodgkin lymphoma
Blood,
February 15, 2006;
107(4):
1255 - 1264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-Q. Du and P. G. Isaacson
First Steps in Unraveling the Genotype of Enteropathy-Type T-Cell Lymphoma
Am. J. Pathol.,
November 1, 2002;
161(5):
1527 - 1529.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Quintanilla-Martinez, S. Kumar, F. Fend, E. Reyes, J. Teruya-Feldstein, D. W. Kingma, L. Sorbara, M. Raffeld, S. E. Straus, and E. S. Jaffe
Fulminant EBV+ T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome
Blood,
July 15, 2000;
96(2):
443 - 451.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Chott, W. Haedicke, I. Mosberger, M. Fodinger, K. Winkler, C. Mannhalter, and H.-K. Muller-Hermelink
Most CD56+ Intestinal Lymphomas Are CD8+CD5- T-Cell Lymphomas of Monomorphic Small to Medium Size Histology
Am. J. Pathol.,
November 1, 1998;
153(5):
1483 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
