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Molecular monitoring of minimal residual disease in follicular and mantle
cell non-Hodgkin's lymphomas treated with high-dose chemotherapy and
peripheral blood progenitor cell autografting
P Corradini, M Astolfi, C Cherasco, M Ladetto, C Voena, D Caracciolo, A Pileri and C Tarella
Dipartimento di Medicina ed Oncologia Sperimentale, Divisione Universitaria
di Ematologia-Azienda Ospedaliera San Giovanni Battista, Torino, Italy.
Minimal residual disease (MRD) was evaluated in 30 patients with follicular
or mantle cell non-Hodgkin's lymphoma (NHL) undergoing an intensive
treatment with high-dose sequential (HDS) chemotherapy and peripheral blood
progenitor cell (PBPC) autografting. To minimize the potential tumor cell
contamination, PBPC harvests were scheduled at the end of HDS pretransplant
phase. All patients had advanced-stage disease and most of them presented
with bone marrow (BM) involvement. A tumor marker could be generated in 90%
of patients using bcl-2 or lg heavy- chain genes. MRD was analyzed on PBPC,
BM harvests, and after autografting by polymerase chain reaction (PCR). All
evaluable follicular and 6 of 9 mantle cell patients achieved clinical
complete remission. PCR negativity of PBPC and/or BM harvests was
documented in 68% of follicular and 12% of mantle cell lymphomas. Molecular
remission of PBPC and/or BM harvests was achieved in 9 of 15 patients with
overt marrow involvement and in all patients with only molecular marrow
infiltration at onset. Molecular follow-up was conducted on 14 patients:
all 7 evaluable patients who received at least one PCR- negative graft
maintained the negative status at a median follow-up of 24 months and none
of them relapsed so far. Thus, the results show that (1) a molecular marker
to monitor MRD can be obtained in most follicular and mantle cell NHL
patients, (2) the HDS regimen may provide PCR-negative PBPC and/or BM
harvests even from patients with BM disease, and (3) autograft with at
least one PCR-negative harvest is associated with a durable clinical and
molecular remission.
Volume 89,
Issue 2,
pp. 724-731,
01/15/1997
Copyright © 1997 by The American Society of Hematology
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|
|
|
|
|
|
|
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[Full Text]
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|
|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
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[Full Text]
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|
|
|
|
|
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|
P. Corradini, C. Voena, C. Tarella, M. Astolfi, M. Ladetto, A. Palumbo, M. T. Van Lint, A. Bacigalupo, A. Santoro, M. Musso, et al.
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January 1, 1999;
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208 - 208.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vockerodt, M. Soares, H. Kanzler, R. Kuppers, D. Kube, M.-L. Hansmann, V. Diehl, and H. Tesch
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92(8):
2899 - 2907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. N. Rezuke, E. C. Abernathy, and G. J. Tsongalis
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Clin. Chem.,
October 1, 1997;
43(10):
1814 - 1823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
