|
|
 Previous Article | Table of Contents | Next Article 
Stat1 is induced and activated by all-trans retinoic acid in acute
promyelocytic leukemia cells
M Gianni, M Terao, I Fortino, M LiCalzi, V Viggiano, T Barbui, A Rambaldi and E Garattini
Molecular Biology Unit, Centro Catullo e Daniela Borgomainerio, Istituto di
Ricerche Farmacologiche Mario Negri, Milan, Italy.
Treatment of freshly isolated acute promyelocytic leukemia (APL) cells and
the myelogenous leukemia cell lines, NB4, HL-60, and U937, with all- trans
retinoic acid (ATRA) results in a remarkable elevation in the amounts of
Stat1 alpha and Stat2 proteins. Stat1 alpha protein levels are augmented by
ATRA as a consequence of elevated amounts of the corresponding transcripts.
The retinoid increases the levels of nuclear complexes that are capable of
binding to interferon (IFN)-regulated consensus sequences and contain Stat1
and/or Stat2 proteins, and causes a rapid and long-lasting elevation in
Stat1 alpha tyrosine phosphorylation. Transient transfection experiments
show that ATRA enhances the transactivating properties of Stat1 alpha
observed on an appropriate reporter gene, in the presence of the RAR alpha
retinoic acid receptor, but not in the presence of the PML-RAR protein.
Treatment of NB4 cells with ATRA is associated with a remarkable
upregulation of the two IFN-responsive genes IFN-responsive factor 1 and
2'-5' oligoadenylate synthetase, as well as with an augmentation in the
levels of IFN alpha secretion. Our data show that ATRA is capable of
modulating the amounts and the state of activation of some of the
components of the IFN intracellular signaling pathways. They also suggest
that the retinoid can bypass IFN/IFN-receptor interactions and induce the
expression of IFN-regulated genes.
Volume 89,
Issue 3,
pp. 1001-1012,
02/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Gianni', A. Boldetti, V. Guarnaccia, A. Rambaldi, E. Parrella, I. Raska Jr., C. Rochette-Egly, G. Del Sal, A. Rustighi, M. Terao, et al.
Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RAR{alpha} and PML-RAR{alpha}
Cancer Res.,
February 1, 2009;
69(3):
1016 - 1026.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. M. Luo and A. C. Ross
Physiological and Receptor-selective Retinoids Modulate Interferon {gamma} Signaling by Increasing the Expression, Nuclear Localization, and Functional Activity of Interferon Regulatory Factor-1
J. Biol. Chem.,
October 28, 2005;
280(43):
36228 - 36236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Licht and A. Zelent
Retinoid and growth factor receptor signaling in APL
Blood,
February 15, 2005;
105(4):
1381 - 1382.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Parrella, M. Gianni', V. Cecconi, E. Nigro, M. M. Barzago, A. Rambaldi, C. Rochette-Egly, M. Terao, and E. Garattini
Phosphodiesterase IV Inhibition by Piclamilast Potentiates the Cytodifferentiating Action of Retinoids in Myeloid Leukemia Cells: CROSS-TALK BETWEEN THE cAMP AND THE RETINOIC ACID SIGNALING PATHWAYS
J. Biol. Chem.,
October 1, 2004;
279(40):
42026 - 42040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kambhampati, Y. Li, A. Verma, A. Sassano, B. Majchrzak, D. K. Deb, S. Parmar, N. Giafis, D. V. Kalvakolanu, A. Rahman, et al.
Activation of Protein Kinase C{delta} by All-trans-retinoic Acid
J. Biol. Chem.,
August 29, 2003;
278(35):
32544 - 32551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dimberg, I. Karlberg, K. Nilsson, and F. Oberg
Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells
Blood,
July 1, 2003;
102(1):
254 - 261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler
Signal transducer and activator of transcription proteins in leukemias
Blood,
April 15, 2003;
101(8):
2940 - 2954.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ravandi, M. Talpaz, and Z. Estrov
Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies
Clin. Cancer Res.,
February 1, 2003;
9(2):
535 - 550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pisano, P. Kollar, M. Gianni, Y. Kalac, V. Giordano, F. F. Ferrara, R. Tancredi, A. Devoto, A. Rinaldi, A. Rambaldi, et al.
Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells
Blood,
November 15, 2002;
100(10):
3719 - 3730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Lindner, X. Ma, J. Hu, S. Karra, and D. V. Kalvakolanu
Thioredoxin Reductase Plays a Critical Role in IFN Retinoid-mediated Tumor-Growth Control in Vivo
Clin. Cancer Res.,
October 1, 2002;
8(10):
3210 - 3218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Watanabe, M. Kurabayashi, M. Arai, K. Sekiguchi, and R. Nagai
Combined effect of retinoic acid and basic FGF on PAI-1 gene expression in vascular smooth muscle cells
Cardiovasc Res,
July 1, 2001;
51(1):
151 - 159.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gianni', Y. Kalac, I. Ponzanelli, A. Rambaldi, M. Terao, and E. Garattini
Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RAR{alpha} and PML-RAR{alpha}
Blood,
May 15, 2001;
97(10):
3234 - 3243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dimberg, K. Nilsson, and F. Oberg
Phosphorylation-deficient Stat1 inhibits retinoic acid-induced differentiation and cell cycle arrest in U-937 monoblasts
Blood,
October 15, 2000;
96(8):
2870 - 2878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Ponzanelli, M. Gianni, R. Giavazzi, A. Garofalo, I. Nicoletti, U. Reichert, E. Erba, A. Rambaldi, M. Terao, and E. Garattini
Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid
Blood,
April 15, 2000;
95(8):
2672 - 2682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-H. Chen, D. Lavelle, J. DeSimone, S. Uddin, L. C. Platanias, and M. Hankewych
Growth Inhibition of a Human Myeloma Cell Line by All-trans Retinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21WAF1
Blood,
July 1, 1999;
94(1):
251 - 259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick and J. D. Licht
Deconstructing a Disease: RAR{alpha}, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
Blood,
May 15, 1999;
93(10):
3167 - 3215.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A. Percario, V. Giandomenico, G. Fiorucci, M. V. Chiantore, S. Vannucchi, J. Hiscott, E. Affabris, and G. Romeo
Retinoic Acid Is Able to Induce Interferon Regulatory Factor 1 in Squamous Carcinoma Cells via a STAT-1 Independent Signalling Pathway
Cell Growth Differ.,
April 1, 1999;
10(4):
263 - 270.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Mologni, I. Ponzanelli, F. Bresciani, G. Sardiello, D. Bergamaschi, M. Gianni, U. Reichert, A. Rambaldi, M. Terao, and E. Garattini
The Novel Synthetic Retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases
Blood,
February 1, 1999;
93(3):
1045 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yu, J.-H. Tong, M. Mao, L.-X. Kan, M.-M. Liu, Y.-W. Sun, G. Fu, Y.-K. Jing, L. Yu, D. Lepaslier, et al.
Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
PNAS,
July 8, 1997;
94(14):
7406 - 7411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Angell, D. J. Lindner, P. S. Shapiro, E. R. Hofmann, and D. V. Kalvakolanu
Identification of GRIM-19, a Novel Cell Death-regulatory Gene Induced by the Interferon-beta and Retinoic Acid Combination, Using a Genetic Approach
J. Biol. Chem.,
October 20, 2000;
275(43):
33416 - 33426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Alsayed, S. Uddin, N. Mahmud, F. Lekmine, D. V. Kalvakolanu, S. Minucci, G. Bokoch, and L. C. Platanias
Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid
J. Biol. Chem.,
February 2, 2001;
276(6):
4012 - 4019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-B. Yang, Z.-J. Duan, W. Yao, O. Lee, L. Yang, X.-Y. Yang, X. Sun, C. C. Y. Chang, T.-Y. Chang, and B.-L. Li
Synergistic Transcriptional Activation of Human Acyl-coenzyme A: Cholesterol Acyltransterase-1 Gene by Interferon-gamma and All-trans-Retinoic Acid THP-1 Cells
J. Biol. Chem.,
June 8, 2001;
276(24):
20989 - 20998.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Ma, S. Karra, W. Guo, D. J. Lindner, J. Hu, J. E. Angell, E. R. Hofmann, S. P. M. Reddy, and D. V. Kalvakolanu
Regulation of Interferon and Retinoic Acid-induced Cell Death Activation through Thioredoxin Reductase
J. Biol. Chem.,
June 29, 2001;
276(27):
24843 - 24854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
