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Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas
B Gamberi, G Gaidano, N Parsa, A Carbone, S Roncella, DM Knowles, DC Louie, D Shibata, RS Chaganti and R Dalla-Favera
Department of Pathology, College of Physicians and Surgeons, Columbia
University, New York 10032, USA.
Microsatellite instability (MSI), a symptom of defect in DNA mismatch
repair function, represents a type of genomic instability frequently
detected in many types of cancers. However, the involvement of MSI in
non-Hodgkin's lymphomas (NHL) has not been conclusively investigated. In
this study, we have tested the presence of MSI in 69 cases of B-cell NHL
(B-NHL) representative of the various histologic categories of the disease
and including 17 cases of acquired immunodeficiency syndrome (AIDS)-related
B-NHL (AIDS-NHL). In addition, for selected B-NHL cases, consecutive
samples obtained before and after clinical progression (with and without
concomitant histologic transformation) were also investigated. Five
distinct microsatellite repeats (2 dinucleotide, 2 trinucleotide, and 1
tetranucleotide repeats) were analyzed by polymerase chain reaction in all
cases. MSI, defined by the presence of microsatellite alterations in two or
more of the five microsatellite loci tested, was not found in NHL. In
contrast to a previous study reporting the frequent association between MSI
and AIDS-NHL, we found this abnormality in only 1 of 17 cases of AIDS-NHL
representative of the major subtypes. Overall, these data indicate that
defects in DNA mismatch repair do not contribute significantly to the
molecular pathogenesis of B-NHL.
Volume 89,
Issue 3,
pp. 975-979,
02/01/1997
Copyright © 1997 by The American Society of Hematology
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