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Telomerase activity is induced in human peripheral B lymphocytes by the
stimulation to antigen receptor
H Igarashi and N Sakaguchi
Department of Immunology, Kumamoto University School of Medicine, Japan.
To understand the molecular events for the proliferation of B cells, we
studied the induction of telomerase activity in vitro after stimulation to
B-cell antigen receptor (BCR) on human peripheral B cells. Although
unstimulated purified B cells of tonsils and peripheral blood from healthy
volunteers do not express detectable telomerase activity, anti- IgM beads
induce telomerase activity in these B cells. Soluble anti-IgM antibody (Ab)
alone does not induce telomerase activity, but the second signal, given by
either one of the cytokines of interleukin-2 (IL-2), IL-4, and IL-13 or by
anti-CD40 monoclonal Ab (MoAb), is effective as the costimulation for the
induction of the activity. Stimulation with anti-IgM Ab and anti-CD40 MoAb
induces telomerase activity in most mature B cells of the tonsils and
peripheral blood. The stimuli to both IgM and IgD receptors similarly
induce the activity. Induction of telomerase activity is accompanied with
the proliferation of B cells, but is not absolutely correlated with the
extent of B-cell growth. Phorbol dibutylate (PDB) plus calcium (Ca)
ionophore (PDB/Ca), which replace the activation through BCR and the
costimulatory molecules, also induce telomerase activity. Moreover, it is
suggested that phosphoinositide (PI) 3-kinase plays a role for the
induction of telomerase activity in B cells stimulated with anti-IgM Ab and
anti- CD40 MoAb. These results suggest that telomerase activity is induced
in the B-cell activation of the antigen specific immune response.
Volume 89,
Issue 4,
pp. 1299-1307,
02/15/1997
Copyright © 1997 by The American Society of Hematology
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