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Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein
nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the
monoclonal antibody ALK1
K Pulford, L Lamant, SW Morris, LH Butler, KM Wood, D Stroud, G Delsol and DY Mason
University Department of Cellular Science, John Radcliffe Hospital, Oxford,
UK.
The t(2;5)(p23;q35) translocation, associated with anaplastic large- cell
lymphoma (ALCL), results in the production of the nucleolar protein
nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) protein. This report
describes an immunocytochemical study of the distribution of ALK and
NPM-ALK proteins using a new monoclonal antibody, ALK1, that recognizes a
formalin resistant epitope in both the 80-kD NPM-ALK chimeric and the
200-kD normal human ALK proteins. Cytoplasmic and nuclear labeling was seen
in the t(2;5)+ SU-DHL-1 and Karpas 299 cell lines. Normal ALK protein
expression was restricted to the central nervous system (in scattered
neurons, glial cells, and endothelial cells). Two hundred and thirty-nine
cases of lymphoma and 80 nonhematopoietic tumors were immunostained.
Antibody ALK1 labeled 53.4% (39 of 73 cases) of CD30+ ALCL. A case of ALCL
with a t(1;2) translocation was ALK1+. Three cases of CD30- ALCL with
prominent nucleoli showed a unique pattern of coarse granular cytoplasmic
labeling. All other tumors, including Hodgkin's disease and lymphomatoid
papulosis, were ALK1-. These results indicate that reliable immunostaining
of routine biopsy material for NPM-ALK and ALK proteins is feasible. Such
analysis is of diagnostic importance, especially because t(2;5)+ ALCL cases
have a good prognosis with appropriate treatment.
Volume 89,
Issue 4,
pp. 1394-1404,
02/15/1997
Copyright © 1997 by The American Society of Hematology
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