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Leptin stimulates fetal and adult erythroid and myeloid development
AA Mikhail, EX Beck, A Shafer, B Barut, JS Gbur, TJ Zupancic, AC Schweitzer, JA Cioffi, G Lacaud, B Ouyang, G Keller and HR Snodgrass
Progenitor, Inc, Columbus, OH 43212, USA.
The ob gene product, leptin, has been shown in several studies to be
involved in weight control and recombinant leptin recently has entered
clinical trials to treat obesity. The leptin receptor (OB-R/B219) is
expressed in a variety of protein isoforms not only in the central nervous
system, but also in reproductive, and hematopoietic tissues. We reported
recently that the OB-R/B219 was associated with a variety of hematopoietic
lineages as well as the small fraction of cells containing the long-term
reconstituting hematopoietic stem cells. Herein we report that leptin
significantly stimulates the proliferation and differentiation of yolk sac
cells and fetal liver cells and stimulates directly hematopoietic
precursors. Leptin alone can increase the number of macrophage and
granulocyte colonies, and leptin plus erythropoietin act synergistically to
increase erythroid development. These data show that leptin has a
significant, direct effect on early hematopoietic development and can
stimulate the differentiation of lineage-restricted precursors of the
erythrocytic and myelopoietic lineages. These observations along with a
recent report strongly support our previous hypothesis that leptin has an
unanticipated important role in hematopoietic and immune system
development.
Volume 89,
Issue 5,
pp. 1507-1512,
03/01/1997
Copyright © 1997 by The American Society of Hematology
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