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Expression of matrix metalloproteinases and tissue inhibitors of
metalloproteinases in reactive and neoplastic lymphoid cells
M Stetler-Stevenson, A Mansoor, M Lim, P Fukushima, J Kehrl, G Marti, K Ptaszynski, J Wang and WG Stetler-Stevenson
Flow Cytometry Unit, National Cancer Institute, Bethesda, NIH, Bethesda, MD
20892, USA.
We have studied the expression of gelatinase A, gelatinase B, interstitial
collagenase, tissue inhibitor of metalloproteinase (TIMP)- 1 and TIMP-2 in
reactive lymphoid cells, as well as in a series of cell lines derived from
neoplasms of B- and T-cell lineage. Using both Northern blot analysis and
zymography, gelatinase B activity was detected by zymography in two Burkitt
cell lines and in a tonsillar cell suspension, while gelatinase A and
interstitial collagenase activities were not detected by either method.
TIMP-1 expression was demonstrated by Northern blot analysis in the
multipotential neoplastic K-562 cell line, the high grade Burkitt's B-cell
lymphoma lines, isolated tonsillar B cells and at low levels in peripheral
blood T cells, but was not expressed in any of the neoplastic T-cell lines
or isolated peripheral blood B cells. In contrast, TIMP-2 expression was
restricted to tissues containing cells of T-cell lineage with high levels
being observed in the neoplastic T-cell lines and lower levels in normal
peripheral blood T cells and hyperplastic tonsil. Expression of TIMP-1 and
TIMP-2 was confirmed at the protein level by reverse zymography and
immunofluorescence assays using antihuman TIMP polyclonal antibodies.
Expression of gelatinase B by the high grade B- cell Burkitt's lymphoma
cell lines is consistent with previous findings in large cell immunoblastic
lymphomas and indicates that this enzyme may play an important role in high
grade non-Hodgkin's lymphomas. TIMP expression correlated with cell lineage
in that TIMP-1 was primarily observed in B cells and TIMP-2 was restricted
to T cells.
Volume 89,
Issue 5,
pp. 1708-1715,
03/01/1997
Copyright © 1997 by The American Society of Hematology
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