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A new subtype of pre-B acute lymphoblastic leukemia with
t(5;12)(q31q33;p12), molecularly and cytogenetically distinct from t(5;12)
in chronic myelomonocytic leukemia
I Wlodarska, A Aventin, J Ingles-Esteve, D Falzetti, A Criel, JJ Cassiman, C Mecucci, H Van den Berghe and P Marynen
Center for Human Genetics, Flemish Interuniversity, University of Leuven,
Belgium.
Translocation t(5;12)(q33;p13), resulting in an ETV6/PDGFRB gene fusion, is
a recurrent chromosomal abnormality associated with chronic myelomonocytic
leukemia (CMML). An analogous translocation was also found in four cell
lines with features of pre-B acute lymphoblastic leukemia (ALL). Using
fluorescence in situ hybridization (FISH) we show here that in three of
these cell lines identical complex rearrangements occurred. However, the
regions involved on 5q and 12p are different from the breakpoints in CMML,
and the translocation is accompanied by seemingly identical cryptic
deletions of both 5q and 12p chromosome sequences in all analyzed pre-B ALL
cell lines. The similar cytogenetic, FISH, and immunophenotyping findings
in the three cell lines suggest that the t(5;12)(q31q33;p12) defines a new
entity of pre- B ALL.
Volume 89,
Issue 5,
pp. 1716-1722,
03/01/1997
Copyright © 1997 by The American Society of Hematology
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