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Traditional beer consumption and the iron status of spouse pairs from a
rural community in Zimbabwe
VM Moyo, IT Gangaidzo, ZA Gomo, H Khumalo, T Saungweme, CF Kiire, T Rouault and VR Gordeuk
Department of Medicine, Medical School, University of Zimbabwe, Harare.
To examine the relationship between dietary iron exposure through the
consumption of traditional beer and the presence of iron overload in black
Africans not related by birth, we studied 28 husband and wife pairs from a
rural Zimbabwean community. Lifetime traditional beer consumption was
estimated by questioning subjects and iron status was assessed by repeated
measurements of serum ferritin and transferrin saturation in subjects who
were fasting and had received vitamin C supplementation. Each of the 56
study subjects had an estimated lifetime traditional beer consumption
>1,000 L. The mean +/- standard deviation (SD) concentration of iron in
the supernatants of nine samples of traditional beer from the community was
46 +/- 10 mg/L. Four of 28 men (14.3%) and no women had the combination of
an elevated serum ferritin and a transferrin saturation >70%, suggestive
of substantial iron overload. Significant correlations were not found
between the iron status of the husbands and their wives or between dietary
iron exposure and iron stores. Our findings suggest that dietary iron
exposure may not fully explain the development of iron overload in Africans
and are consistent with the hypothesis that an iron-loading gene may also
be implicated in pathogenesis.
Volume 89,
Issue 6,
pp. 2159-2166,
03/15/1997
Copyright © 1997 by The American Society of Hematology
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