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Lineage- and stage-specific expression of runt box polypeptides in
primitive and definitive hematopoiesis
MT Corsetti and F Calabi
Developmental Biology Unit, Division of Cell and Molecular Biology,
Institute of Child Health, London, UK.
Translocations involving the human CBFA2 locus have been associated with
leukemia. This gene, originally named AML1, is a human homologue of the
Drosophila gene runt that controls early events in fly embryogenesis. To
clarify the role of mammalian runt products in normal and leukemic
hematopoiesis, we have studied their pattern of expression in mouse
hematopoietic tissues in the adult and during ontogeny using an anti-runt
box antiserum. In the adult bone marrow, we found expression of runt
polypeptides in differentiating myeloid cells and in B lymphocytes. Within
the erythroid lineage, runt expression is biphasic, clearly present in the
erythroblasts of early blood islands and of the fetal liver, but absent in
the adult. Biochemical analysis by Western blotting of fetal and adult
hematopoietic populations shows several runt isoforms. At least one of them
appears to be myeloid specific.
Volume 89,
Issue 7,
pp. 2359-2368,
04/01/1997
Copyright © 1997 by The American Society of Hematology
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