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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bombeli, T. Articles by Harlan, J. M. Search for Related Content PubMed PubMed Citation Articles by Bombeli, T. Articles by Harlan, J. M. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Apoptotic vascular endothelial cells become procoagulant T Bombeli, A Karsan, JF Tait and JM Harlan Department of Laboratory Medicine, University of Washington, Seattle 98195, USA. Whereas unperturbed endothelial cells provide potent anticoagulant properties, exposure to inflammatory and atherogenic stimuli can rapidly lead to a procoagulant behavior. Because recent studies provide evidence that apoptosis of vascular cells may occur under conditions such as atherosclerosis and inflammation, we investigated whether apoptotic endothelial cells may contribute to the development of a prothrombotic state. In this report, it is shown that both adherent and detached apoptotic human umbilical vein endothelial cells (HUVECs) become procoagulant. Apoptosis was induced by staurosporine, a nonspecific protein kinase inhibitor, or by culture in suspension with serum deprivation. Both methods resulted in similar findings. As assessed by flow cytometric determination of annexin V binding, HUVECs undergoing cell death exhibited typically a more rapid exposure of membrane phosphatidylserine (PS) than DNA fragmentation. Depending on the stage of apoptosis, this redistribution of phospholipids was found to induce an increase of the activity of the intrinsic tenase complex by 25% to 60%. Although apoptotic cells did not show antigenic or functional tissue factor (TF) activity, when preactivated with lipopolysaccharide, TF procoagulant activity increased by 50% to 70%. At 8 hours after apoptosis induction, antigenic thrombomodulin, heparan sulfates, and TF pathway inhibitor decreased by about 83%, 80%, and 59%, respectively. The functional activity of these components was reduced by about 36%, 52%, and 39%, respectively. Moreover, the presence of apoptotic HUVECs led to a significant increase of thrombin formation in recalcified citrated plasma. In conclusion, apoptotic HUVECs, either adherent or in suspension, become procoagulant by increased expression of PS and the loss of anticoagulant membrane components. Volume 89, Issue 7, pp. 2429-2442, 04/01/1997 Copyright © 1997 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Kumar, S. Kostin, J.-P. Flacke, H. P. Reusch, and Y. Ladilov Soluble Adenylyl Cyclase Controls Mitochondria-dependent Apoptosis in Coronary Endothelial Cells J. Biol. Chem., May 29, 2009; 284(22): 14760 - 14768. [Abstract] [Full Text] [PDF] A. Maselli, P. Matarrese, E. Straface, S. Canu, F. Franconi, and W. Malorni Cell sex: a new look at cell fate studies FASEB J, April 1, 2009; 23(4): 978 - 984. [Abstract] [Full Text] [PDF] A. Graham, I. Ford, R. Morrison, R. N. Barker, M. Greaves, and L.-P. Erwig Anti-Endothelial Antibodies Interfere in Apoptotic Cell Clearance and Promote Thrombosis in Patients with Antiphospholipid Syndrome J. Immunol., February 1, 2009; 182(3): 1756 - 1762. [Abstract] [Full Text] [PDF] A. Le, R. Damico, M. Damarla, A. Boueiz, H. 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