|
|
 Previous Article | Table of Contents | Next Article 
Intravenous anti-D treatment of immune thrombocytopenic purpura: experience
in 272 patients
A Scaradavou, B Woo, BM Woloski, S Cunningham-Rundles, LJ Ettinger, LM Aledort and JB Bussel
Department of Pediatrics, The New York Hospital-Cornell Medical Center, New
York, NY 10021, USA.
We report the results of intravenous anti-D (WinRho, WinRho SD) therapy in
261 non-splenectomized patients treated at the New York Hospital- Cornell
Medical Center over the period from 1987 to 1994. Children (n = 124) and
adult patients (n = 137) with classic immune thrombocytopenic purpura (ITP;
n = 156) or human immunodeficiency virus (HIV) related thrombocytopenia (n
= 105) and acute (n = 75) or chronic (n = 186) disease at the time of the
initial anti-D treatment were studied. In addition, 11 previously
splenectomized patients were treated as a separate group. Our objectives
were to evaluate the following. (1) Efficacy of anti-D: The response after
the initial infusion was analyzed according to clinical parameters, such as
patient's age, HIV status, gender, disease duration, pretreatment platelet
count, and hemoglobin value, as well as treatment-related factors,
including the dose of anti-D, the solvent detergent treatment of the
preparation, and the type of administration. (2) Use of anti-D as
maintenance therapy: The duration of response after the initial infusion
and the results of subsequent treatments were evaluated. (3)
Safety/toxicity of anti-D: Postinfusion reactions and hemoglobin decrease
after treatment were studied. Anti-D is a safe treatment providing a
hemostatic platelet increase in greater than 70% of the Rh+
non-splenectomized patients. The group with the best results is HIV-
children, but all patient groups respond and the effect lasts more than 21
days in 50% of the responders. Duration of response is not influenced by
HIV status; furthermore, HIV+ patients show no adverse effects on
hemoglobin decrease or HIV disease progression. Patients with chronic ITP
after splenectomy have minimal or no response to intravenous anti-D.
Volume 89,
Issue 8,
pp. 2689-2700,
04/15/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
B. Godeau, R. Porcher, O. Fain, F. Lefrere, P. Fenaux, S. Cheze, A. Vekhoff, M.-P. Chauveheid, J. Stirnemann, L. Galicier, et al.
Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study
Blood,
August 15, 2008;
112(4):
999 - 1004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ruggeri, S. Fortuna, and F. Rodeghiero
Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature
Haematologica,
January 1, 2008;
93(1):
98 - 103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Dimaano, M. Saito, S. Honda, E. A. Miranda, M. T. G. Alonzo, M. D. Valerio, C. A. Mapua, S. Inoue, A. Kumaori, R. Matias, et al.
Lack of Efficacy of High-Dose Intravenous Immunoglobulin Treatment of Severe Thrombocytopenia in Patients with Secondary Dengue Virus Infection
Am J Trop Med Hyg,
December 1, 2007;
77(6):
1135 - 1138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kjaersgaard, R. Aslam, M. Kim, E. R. Speck, J. Freedman, D. I. H. Stewart, E. J. Wiersma, and J. W. Semple
Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets
Blood,
August 15, 2007;
110(4):
1359 - 1361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Deng and J. P. Balthasar
Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia
Blood,
March 15, 2007;
109(6):
2470 - 2476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Cines and J. B. Bussel
How I treat idiopathic thrombocytopenic purpura (ITP)
Blood,
October 1, 2005;
106(7):
2244 - 2251.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Song, A. R. Crow, V. Siragam, J. Freedman, and A. H. Lazarus
Monoclonal antibodies that mimic the action of anti-D in the amelioration of murine ITP act by a mechanism distinct from that of IVIg
Blood,
February 15, 2005;
105(4):
1546 - 1548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Manno
Management of Bleeding Disorders in Children
Hematology,
January 1, 2005;
2005(1):
416 - 422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Song, A. R. Crow, J. Freedman, and A. H. Lazarus
Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG
Blood,
May 1, 2003;
101(9):
3708 - 3713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Cines and V. S. Blanchette
Immune Thrombocytopenic Purpura
N. Engl. J. Med.,
March 28, 2002;
346(13):
995 - 1008.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H J Longhurst, C O'Grady, G Evans, C De Lord, A Hughes, J Cavenagh, and M R Helbert
Anti-D immunoglobulin treatment for thrombocytopenia associated with primary antibody deficiency
J. Clin. Pathol.,
January 1, 2002;
55(1):
64 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. McCrae, J. B. Bussel, P. M. Mannucci, G. Remuzzi, and D. B. Cines
Platelets: An Update on Diagnosis and Management of Thrombocytopenic Disorders
Hematology,
January 1, 2001;
2001(1):
282 - 305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Gaines
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rho(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients
Blood,
April 15, 2000;
95(8):
2523 - 2529.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Avent and M. E. Reid
The Rh blood group system: a review
Blood,
January 15, 2000;
95(2):
375 - 387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Bussel, T. J. Kunicki, and A. D. Michelson
Platelets: New Understanding of Platelet Glycoproteins and Their Role in Disease
Hematology,
January 1, 2000;
2000(1):
222 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gerald Sandler, D. Mallory, J. Trimble, and S. T. Nance
Intravenous Anti-D Treatment for Immune Thrombocytopenic Purpura
Blood,
April 1, 1998;
91(7):
2624 - 2625.
[Full Text]
[PDF]
|
|
|
|
|
