|
|
 Previous Article | Table of Contents | Next Article 
Oligoclonal CD4+ CD57+ T-cell expansions contribute to the imbalanced T-
cell receptor repertoire of rheumatoid arthritis patients
L Imberti, A Sottini, S Signorini, R Gorla and D Primi
Consorzio per le Biotecnologie, Terzo Laboratorio Analisi, Clinic
Immunology Department, Spedali Civili, Brescia, Italy.
A peculiar feature of rheumatoid arthritis patients is that they carry
clonally expanded CD4+ and CD8+ cells in the peripheral blood. While the
distortion of the repertoire of CD8+ cells has been ascribed to the
increase of CD8+ CD57+ large granular lymphocytes, often detected in these
patients, the mechanism responsible for the clonal expansion of CD4+ cells
remains unexplained. Here, we report that CD4+ CD57+ cells, that in healthy
individuals represent a small subset of peripheral CD4+ lymphocytes, are
significantly expanded in the peripheral blood of a considerable percentage
of rheumatoid arthritis patients. Furthermore, the expansion of these
lymphocytes appears to correlate with the presence of rheumatoid factor.
The molecular analysis of the T-cell receptor variable beta segments
expressed by the CD4+ CD57+ cells enriched in rheumatoid arthritis patients
showed that they use restricted repertoires, that partially overlap with
those of their CD4- CD57+ counterpart. The structural feature of the
receptor ligand expressed by these cells revealed that their expansion is
most likely mediated by strong antigenic pressures. However, since we also
found that CD4+ CD57+ and CD4- CD57+ cells can share the same clonal
specificity, it is likely that their selection is not mediated by
conventional major histocompatibility complex restricted mechanisms. Thus,
while our data demonstrate that CD4+ CD57+ cells play an important role in
establishing the imbalance of the CD4+ cell repertoire observed in
rheumatoid arthritis patients, they also suggest that these cells have
common features with mouse CD4+ CD8- NK1.1+/T cells.
Volume 89,
Issue 8,
pp. 2822-2832,
04/15/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P Airo, M Scarsi, A Brucato, T Benicchi, F Malacarne, I Cavazzana, E Danieli, M LiDestri, M Motta, L Caimi, et al.
Characterization of T-cell population in children with prolonged fetal exposure to dexamethasone for anti-Ro/SS-A antibodies associated congenital heart block
Lupus,
September 1, 2006;
15(9):
553 - 561.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. E. Palmer, N. Blyveis, A. P. Fontenot, and C. C. Wilson
Functional and Phenotypic Characterization of CD57+CD4+ T Cells and Their Association with HIV-1-Induced T Cell Dysfunction
J. Immunol.,
December 15, 2005;
175(12):
8415 - 8423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Marleau and N. Sarvetnick
T cell homeostasis in tolerance and immunity
J. Leukoc. Biol.,
September 1, 2005;
78(3):
575 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Reijonen, R. Mallone, A.-K. Heninger, E. M. Laughlin, S. A. Kochik, B. Falk, W. W. Kwok, C. Greenbaum, and G. T. Nepom
GAD65-Specific CD4+ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes
Diabetes,
August 1, 2004;
53(8):
1987 - 1994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lima, J. Almeida, M. dos Anjos Teixeira, M. d. C. Alguero, A. H. Santos, A. Balanzategui, M. L. Queiros, P. Barcena, A. Izarra, S. Fonseca, et al.
TCR{alpha}{beta}+/CD4+ Large Granular Lymphocytosis: A New Clonal T-Cell Lymphoproliferative Disorder
Am. J. Pathol.,
August 1, 2003;
163(2):
763 - 771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ponchel, A. W. Morgan, S. J. Bingham, M. Quinn, M. Buch, R. J. Verburg, J. Henwood, S. H. Douglas, A. Masurel, P. Conaghan, et al.
Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis
Blood,
December 15, 2002;
100(13):
4550 - 4556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karadimitris, J. S. Manavalan, H. T. Thaler, R. Notaro, D. J. Araten, K. Nafa, I. A.G. Roberts, M. E. Weksler, and L. Luzzatto
Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
Blood,
October 1, 2000;
96(7):
2613 - 2620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Signorini, L. Imberti, S. Pirovano, A. Villa, F. Facchetti, M. Ungari, F. Bozzi, A. Albertini, A. G. Ugazio, P. Vezzoni, et al.
Intrathymic Restriction and Peripheral Expansion of the T-Cell Repertoire in Omenn Syndrome
Blood,
November 15, 1999;
94(10):
3468 - 3478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Brugnoni, L. D. Notarangelo, A. Sottini, P. Airo, M. Pennacchio, E. Mazzolari, S. Signorini, F. Candotti, A. Villa, P. Mella, et al.
Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient With Autosomal Recessive Severe Combined Immunodeficiency Caused by Defects of the Jak3 Tyrosine Kinase
Blood,
February 1, 1998;
91(3):
949 - 955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
