|
|
 Previous Article | Table of Contents | Next Article 
Expression of the Id family helix-loop-helix regulators during growth and
development in the hematopoietic system
CL Cooper, G Brady, F Bilia, NN Iscove and PJ Quesenberry
Department of Medicine University of Massachusetts Cancer Center, Worcester
01605, USA.
To better understand the molecular mechanism(s) by which growth and
differentiation of the primitive hematopoietic stem cell is initiated, as
well as the means by which the maturing cell can commit to development
along a specific cell lineage, we elected to study the Id family of
helix-loop-helix (HLH) transcriptional regulators. Some members of the HLH
family are expressed in a stage-specific manner during hematopoietic
development and can regulate the ability of immature hematopoietic cells to
terminally differentiate. None of the four Id family genes were detected in
the most primitive progenitors. Id-1 was widely expressed in proliferating
bi- and unipotential progenitors, but its expression was downregulated in
cells of increasing maturity; conversely, Id-2 and, to a limited extent,
Id-3 gene expression increased as cells matured and lost proliferative
capacity. Id-2 expression ran counter to that of Id-1 not only during
maturation, but during periods of cell growth and arrest as well. This is
quite distinct from the nonhematopoietic tissues, in which these two
factors are coordinately expressed and suggests that Id-1 and Id-2 might be
regulating very different events during hematopoiesis than they regulate in
other cell types.
Volume 89,
Issue 9,
pp. 3155-3165,
05/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. A. Panepucci, R. T. Calado, V. Rocha, R. Proto-Siqueira, W. A. Silva Jr., and M. A. Zago
Higher Expression of Transcription Targets and Components of the Nuclear Factor-{kappa}B Pathway Is a Distinctive Feature of Umbilical Cord Blood CD34+ Precursors
Stem Cells,
January 1, 2007;
25(1):
189 - 196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Renne, J. I. Martin-Subero, M. Eickernjager, M.-L. Hansmann, R. Kuppers, R. Siebert, and A. Brauninger
Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin's Lymphoma
Am. J. Pathol.,
August 1, 2006;
169(2):
655 - 664.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Leeanansaksiri, H. Wang, J. M. Gooya, K. Renn, M. Abshari, S. Tsai, and J. R. Keller
IL-3 Induces Inhibitor of DNA-Binding Protein-1 in Hemopoietic Progenitor Cells and Promotes Myeloid Cell Development
J. Immunol.,
June 1, 2005;
174(11):
7014 - 7021.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sakurai, N. Tsuchiya, A. Yamaguchi, Y. Okaji, N. H. Tsuno, T. Kobata, K. Takahashi, and K. Tokunaga
Crucial Role of Inhibitor of DNA Binding/Differentiation in the Vascular Endothelial Growth Factor-Induced Activation and Angiogenic Processes of Human Endothelial Cells
J. Immunol.,
November 1, 2004;
173(9):
5801 - 5809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Y. Ng, B. van Kessel, H. M. Lokhorst, M. R. M. Baert, C. M. M. van den Burg, A. C. Bloem, and F. J. T. Staal
Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity
J. Leukoc. Biol.,
February 1, 2004;
75(2):
314 - 323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sciacca, M. Prisco, A. Wu, A. Belfiore, R. Vigneri, and R. Baserga
Signaling Differences from the A and B Isoforms of the Insulin Receptor (IR) in 32D Cells in the Presence or Absence of IR Substrate-1
Endocrinology,
June 1, 2003;
144(6):
2650 - 2658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nieborowska-Skorska, G. Hoser, P. Kossev, M. A. Wasik, and T. Skorski
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
Blood,
May 29, 2002;
99(12):
4531 - 4539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-j. Liu, B. Ding, H. Wang, and P. Lengyel
The MyoD-Inducible p204 Protein Overcomes the Inhibition of Myoblast Differentiation by Id Proteins
Mol. Cell. Biol.,
May 1, 2002;
22(9):
2893 - 2905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.-L. Xie, A. J. van Wijnen, C. M. van der Meijden, J. L. Stein, and G. S. Stein
Forced Expression of the Interferon Regulatory Factor 2 Oncoprotein Causes Polyploidy and Cell Death in FDC-P1 Myeloid Hematopoietic Progenitor Cells
Cancer Res.,
May 1, 2002;
62(9):
2510 - 2515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
Blood,
January 1, 2002;
99(1):
282 - 289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Navarro, B. Valentinis, B. Belletti, G. Romano, K. Reiss, and R. Baserga
Regulation of Id2 Gene Expression by the Type 1 IGF Receptor and the Insulin Receptor Substrate-1
Endocrinology,
December 1, 2001;
142(12):
5149 - 5157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Prisco, F. Peruzzi, B. Belletti, and R. Baserga
Regulation of Id Gene Expression by Type I Insulin-Like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor
Mol. Cell. Biol.,
August 15, 2001;
21(16):
5447 - 5458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. C. Roberts, R. W. Deed, T. Inoue, J. D. Norton, and A. D. Sharrocks
Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding
Mol. Cell. Biol.,
January 15, 2001;
21(2):
524 - 533.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. L. Holmes, J. D. Haley, L. Cerruti, W.-l. Zhou, H. Zogos, D. E. Smith, J. M. Cunningham, and S. M. Jane
Identification of Id2 as a Globin Regulatory Protein by Representational Difference Analysis of K562 Cells Induced To Express gamma -Globin with a Fungal Compound
Mol. Cell. Biol.,
June 1, 1999;
19(6):
4182 - 4190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Kee and C. Murre
Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12
J. Exp. Med.,
August 17, 1998;
188(4):
699 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Woo, A. Cercek, P.-Y. Desprez, and G. L. Firestone
Involvement of the Helix-Loop-Helix Protein Id-1 in the Glucocorticoid Regulation of Tight Junctions in Mammary Epithelial Cells
J. Biol. Chem.,
September 8, 2000;
275(37):
28649 - 28658.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
