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Recurring structural chromosome abnormalities in peripheral blood
lymphocytes of patients with mycosis fungoides/Sezary syndrome
M Thangavelu, WG Finn, KK Yelavarthi, HH Roenigk , E Samuelson, L Peterson, TM Kuzel and ST Rosen
Department of Obstetrics/Gynecology, Northwestern University Medical
School, Chicago, IL 60611, USA.
Cytogenetic analysis was performed on peripheral blood lymphocyte cultures
from 19 patients with mycosis fungoides (MF)/Sezary syndrome (SS)
stimulated with either phytohemagglutinin, a conventional mitogen, or a
combination of interleukin-2 (IL-2) plus IL-7. The use of both PHA-
stimulated and IL-2 plus IL-7-stimulated cultures enhanced the ability to
identify clonal abnormalities. Clonal abnormalities were observed in 11
patients (53%) including one with monosomy for the sex chromosome as the
sole abnormality. Five of the 11 patients with clonal abnormalities had
normal peripheral white blood cell counts, indicating detectability of
clones in the absence of frankly leukemic disease. The presence of clonal
abnormalities correlated with advanced stage disease and a significantly
reduced survival duration from the time of cytogenetic studies. Clonal
abnormalities involving chromosomes 1 and 8 were observed in six cases. In
five cases with aberrations of chromosome 1, loss of material involved the
region between 1p22 and 1p36. In an additional case, a reciprocal
translocation involving 1p33 was observed. Clonal abnormalities involving
chromosomes 10 and 17 were observed in 5 cases, clonal abnormalities
involving chromosome 2 in 4 cases, and clonal abnormalities involving
chromosomes 4, 5, 6, 9, 13, 15, 19, and 20 in 3 cases. In 2 cases a
der(8)t(8;17)(p11;q11) was observed. Regions of the genome that encode
T-cell receptors were not involved in abnormalities. The region between
1p22 and 1p36 is identified as a region of the genome that requires
detailed analysis toward the identification of potential gene(s) involved
in the process of malignant transformation and/or progression in MF/SS.
Volume 89,
Issue 9,
pp. 3371-3377,
05/01/1997
Copyright © 1997 by The American Society of Hematology
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