Blood, 1954, Vol. 9, No. 6, pp. 648-654.
© 1954 American Society of Hematology, Inc.
Mediterranean Anemia in a Negro Complicated by
Pernicious Anemia of Pregnancy
Report of a Case
MELVIN A. GOLDBERG M.D.1 and
STEVEN O. SCHWARTZ M.D.1
1 Hematology Laboratory and the Hektoen Institute for Medical Research of
the Cook County Hospital, Chicago, Ill.
1. A case is presented of a Negro woman with Mediterranean anemia who
developed megaloblastic anemia of pregnancy in each of three pregnancies.
2. The possibility that Mediterranean anemia predisposes to the development
of pernicious anemia of pregnancy is discussed.
3. With megaloblastic erythropoiesis, anemia became more severe, but the
characteristic red cell hypochromia of Mediterranean disease was masked.
4. Purified liver extract failed to protect against the development of megaloblastic anemia of pregnancy but folic acid produced a satisfactory therapeutic
response.
Submitted on August 12, 1953
Accepted on November 9, 1953
