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EORTC Classification for Primary Cutaneous Lymphomas: A Proposal From the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer
R. Willemze,
H. Kerl,
W. Sterry,
E. Berti,
L. Cerroni,
S. Chimenti,
J.L. Diaz-Peréz,
M.L. Geerts,
M. Goos,
R. Knobler,
E. Ralfkiaer,
M. Santucci,
N. Smith,
J. Wechsler,
W.A. van Vloten, and
C.J.L.M. Meijer
From the Departments of Dermatology and Pathology, Free University Hospital, Amsterdam, The Netherlands; the Department of Dermatology, University of Graz, Austria; the Department of Dermatology, Charité, Humboldt University, Berlin, Germany; the Department of Dermatology, University of Milan, Italy; the Department of Dermatology, University of L'Aquila, Italy; the Department of Dermatology, Cruces Hospital, Bilbao, Spain; the Department of Dermatology, University of Gent, Belgium; the Department of Dermatology, University of Essen, Germany; the Department of Dermatology, University of Vienna, Austria; the Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark; the Department of Pathology, University of Florence, Italy; the Department of Dermatology, St John's Hospital, London, UK; the Department of Pathology, Hospital Henri Mondor, Paris, France; the Department of Dermatology, University of Utrecht, The Netherlands.
Primary cutaneous lymphomas represent a heterogeneous group of T- and B-cell lymphomas that show considerable variation in histology, phenotype, and prognosis. Recently, the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Project Group has reached consensus on a new classification for this group of diseases. The EORTC classification for primary cutaneous lymphomas is based on a combination of clinical, histologic, and immunophenotypic criteria, and thus contains well-defined disease entities rather than histologic subgroups. In addition, this new classification contains a number of provisional entities, which may display characteristic histologic features, but are not yet well defined clinically. These provisional entities account for less than 5% of all primary cutaneous lymphomas. In this report the basic principles of this new classification, as well as the characteristic features of the different disease entities, are described. In addition, survival data of 626 patients with primary cutaneous lymphomas derived from the registry of the Dutch Cutaneous Lymphoma Working Group, illustrating the clinical validity of this new classification, are presented.
Blood, Vol. 90 No. 1 (July 1), 1997:
pp. 354-371
© 1997 by The American Society of Hematology.

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|
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|
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|
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|
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141(3):
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|
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|
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|
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|
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|
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|

|
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|
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|
 |
|

|
 |

|
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|
 |
|

|
 |

|
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|
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|
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|
 |
|

|
 |

|
 |
 
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August 15, 2004;
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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July 1, 2004;
15(7):
1097 - 1108.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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June 1, 2004;
140(6):
751 - 751.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Bcl-2 protein expression is the strongest independent prognostic factor of survival in primary cutaneous large B-cell lymphomas
Blood,
May 15, 2004;
103(10):
3662 - 3668.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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N. Engl. J. Med.,
May 6, 2004;
350(19):
1978 - 1988.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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April 1, 2004;
140(4):
441 - 447.
|
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April 1, 2004;
140(4):
449 - 454.
|
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|
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|
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April 1, 2004;
140(4):
479 - 484.
|
 |
|

|
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|
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March 1, 2004;
140(3):
306 - 312.
[Abstract]
[Full Text]
[PDF]
|
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|

|
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|
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Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems
J. Clin. Oncol.,
February 15, 2004;
22(4):
634 - 639.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
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Site-Specific Expression of Polycomb-Group Genes Encoding the HPC-HPH/PRC1 Complex in Clinically Defined Primary Nodal and Cutaneous Large B-Cell Lymphomas
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February 1, 2 | |