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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Koury, M. J. Articles by Kopsombut, P. Search for Related Content PubMed PubMed Citation Articles by Koury, M. J. Articles by Kopsombut, P. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Folate Deficiency Delays the Onset But Increases the Incidence of Leukemia in Friend Virus-Infected Mice Mark J. Koury, Don J. Park, Danko Martincic, Donald W. Horne, Vladimir Kravtsov, James A. Whitlock, Maria del Pilar Aguinaga, and Prapaporn Kopsombut From the Departments of Medicine, Pediatrics, and Biochemistry of Vanderbilt University and Nashville Veterans Affairs Medical Centers, Nashville, TN and the Comprehensive Sickle Cell Center of Meharry Medical College, Nashville, TN. Clinical studies have indicated that folate deficiency may enhance the development of various malignancies. In animal studies that examined the effect of folate deficiency on malignancies, conflicting results have been reported. In some studies, folate deficiency increased the development and growth of malignant tumors; in others, it decreased the development and growth of malignancies. We examined the effect of transient folate deficiency on the development of leukemia in mice infected with the anemia-inducing strain of Friend leukemia virus. Friend virus disease can be considered as a model for human acute leukemias that are preceded by a preleukemic period. These include leukemias that develop in patients who received previous chemotherapy and/or radiation therapy, as well as patients with chronic granulocytic leukemia or myelodysplasia. Folate deficiency around the time of Friend virus-infection delayed the onset but increased the incidence of leukemia. The rates of rearrangement of the Spi-1 (PU.1 ) oncogene by provirus integration and alteration of the p53 tumor-suppressor gene were the same in leukemia cell lines derived from folate-deficient mice as they were in cell lines from control mice. These results indicate that folate deficiency did not exert its enhancement of leukemogenesis through changes in either Spi-1 or p53, even though these two genes have been found to be the most frequently altered ones in Friend virus-induced leukemias. Our results suggest that folate deficiency may enhance the development of acute leukemia in patients who are at high risk for this disease. Blood, Vol. 90 No. 10 (November 15), 1997: pp. 4054-4061 © 1997 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Courtemanche, I. Elson-Schwab, S. T. Mashiyama, N. Kerry, and B. N. Ames Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro J. Immunol., September 1, 2004; 173(5): 3186 - 3192. [Abstract] [Full Text] [PDF]

	Copyright © 1997 by American Society of Hematology         Online ISSN: 1528-0020