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E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis
Britta Engelhardt,
Dietmar Vestweber,
Rupert Hallmann, and
Martina Schulz
From the Max-Planck Institut für physiologische und klinische Forschung, W. G. Kerckhoff-Institut, Bad Nauheim, Germany; Institut für Zellbiologie ZMBE, Universität Münster, Germany; and Institut für Experimentelle Medizin, Universität Erlangen-Nürnberg, Germany.
In experimental autoimmune encephalomyelitis (EAE) inflammatory cells cross the endothelial blood-brain barrier (BBB) and gain access to the central nervous system (CNS). Here we show that E- and P-selectin are not involved in the recruitment of inflammatory cells across the BBB. Neither expression of E- nor P-selectin is induced in BBB-forming endothelium at any time after initiation of EAE. Some of the inflammatory cells present in the CNS during EAE express ligands for E- or P-selectin. However, anti-E- and P-selectin antibodies influence neither immigration of inflammatory cells across the BBB nor the development of EAE. In general, suppression of E- and P-selectin expression on BBB endothelium is dependent on factors derived from the CNS microenvironment, eg, astrocytes. Our results suggest that during EAE suppression of E- and P-selectin expression on the BBB provides a CNS-specific mechanism to reduce leukocyte recruitment into the CNS.
Blood, Vol. 90 No. 11 (December 1), 1997:
pp. 4459-4472
© 1997 by The American Society of Hematology.
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