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Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli
Tina Yen,
Craig A. Harrison,
Jannine M. Devery,
Sharon Leong,
Siiri E. Iismaa,
Teizo Yoshimura, and
Carolyn L. Geczy
From the School of Pathology, The University of New South Wales, New South Wales, Australia; The Victor Chang Cardiac Research Institute, St Vincent's Hospital, Sydney, New South Wales, Australia; and the Immunopathology Section, Laboratory of Immunobiology, NCI-FCRDC, Frederick, MD.
Microvascular endothelial cells (EC) have multiple functions in inflammatory responses, including the production of chemoattractants that enhance leukocyte transmigration into tissues. Chemotactic protein, 10 kD (CP-10), is an S100 protein with potent chemotactic activity for myeloid cells in vitro and in vivo and is expressed in neutrophils and lipopolysaccharide (LPS)-activated macrophages. We show here that CP-10 is induced in murine endothelioma cell lines (bEnd-3, sEnd-1, and tEnd-1) after activation with LPS and interleukin-1 (IL-1) but not tumor necrosis factor  (TNF) or interferon  (IFN). Induction was not mediated by endogenous release of IL-1 or TNF and was not directly upregulated by phorbol myristate acetate, calcium ionophore, or vitamin D3. EC were exquisitely sensitive to IL-1 activation (3.4 U/mL) and CP-10 mRNA induction with IL-1 occurred earlier (8 hours) than with LPS (12 hours). Furthermore, some microvessels and capillaries in delayed-type hypersensitivity lesions expressed cytoplasmic CP-10. Responses to LPS and not IL-1 in vitro were regulated by the degree of cell confluence and by TNF costimulation. The related MRP-14 mRNA had a different induction pattern. Monomeric and homodimeric CP-10 upregulated by activation was predominantly cell-associated. EC-derived CP-10 may contribute to amplification of inflammatory processes by enhancing leukocyte shape changes and transmigration in the microcirculation.
Blood, Vol. 90 No. 12 (December 15), 1997:
pp. 4812-4821
© 1997 by The American Society of Hematology.
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