|
|
 Previous Article | Table of Contents | Next Article 
RAPID COMMUNICATION
Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome
Reinhold Förster,
Georgina Schweigard,
Sabine Johann,
Thomas Emrich,
Elisabeth Kremmer,
Christoph Nerl, and
Martin Lipp
From the Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany; the Städtisches Krankenhaus München-Schwabing, Abteilung. Hämatologie und Onkologie, München, Germany; the Institute für Experimentelle Chirurgie, der TU München, München, Germany; and the Haematologikum der GSF, München, Germany.
The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation of T-helper memory cells. In the present study, we analyzed the distribution of BLR1 on defined lymphocyte subsets during the progression of acquired immunodeficiency syndrome. It is shown that the proportion of T-helper memory cells coexpressing BLR1 continuously decreases during the infection, whereas a high proportion of  / T cells expressing BLR1 can be found in peripheral blood. The latter subpopulation is restricted to lymphoid tissues in healthy individuals. Most interestingly, in 75% of all human immunodeficiency virus (HIV)+ individuals, peripheral blood B cells were identified as not expressing BLR1 and phenotypically resembling germinal center cells of lymphoid tissue. Using BLR1 as a marker molecule, this study identifies peripheral blood lymphocytes in HIV+ individuals that are usually restricted to lymphoid tissue in healthy individuals. Because HIV infection is active in lymphoid tissue even at the clinically latent stage, aberrant expression of the B-cell homing chemokine receptor BLR1 might be an early indicator for the onset of destruction of lymphoid tissue.
Blood, Vol. 90 No. 2 (July 15), 1997:
pp. 520-525
© 1997 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. M. Dunham, B. Cervasi, J. M. Brenchley, H. Albrecht, A. Weintrob, B. Sumpter, J. Engram, S. Gordon, N. R. Klatt, I. Frank, et al.
CD127 and CD25 Expression Defines CD4+ T Cell Subsets That Are Differentially Depleted during HIV Infection
J. Immunol.,
April 15, 2008;
180(8):
5582 - 5592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Caccamo, L. Battistini, M. Bonneville, F. Poccia, J. J. Fournie, S. Meraviglia, G. Borsellino, R. A. Kroczek, C. La Mendola, E. Scotet, et al.
CXCR5 Identifies a Subset of V{gamma}9V{delta}2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production
J. Immunol.,
October 15, 2006;
177(8):
5290 - 5295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Badr, G. Borhis, D. Treton, C. Moog, O. Garraud, and Y. Richard
HIV Type 1 Glycoprotein 120 Inhibits Human B Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 12, CC Chemokine Ligand (CCL)20, and CCL21
J. Immunol.,
July 1, 2005;
175(1):
302 - 310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moir, A. Malaspina, O. K. Pickeral, E. T. Donoghue, J. Vasquez, N. J. Miller, S. R. Krishnan, M. A. Planta, J. F. Turney, J. S. Justement, et al.
Decreased Survival of B Cells of HIV-viremic Patients Mediated by Altered Expression of Receptors of the TNF Superfamily
J. Exp. Med.,
September 6, 2004;
200(5):
587 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Malaspina, S. Moir, S. Kottilil, C. W. Hallahan, L. A. Ehler, S. Liu, M. A. Planta, T.-W. Chun, and A. S. Fauci
Deleterious Effect of HIV-1 Plasma Viremia on B Cell Costimulatory Function
J. Immunol.,
June 15, 2003;
170(12):
5965 - 5972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moir, K. M. Ogwaro, A. Malaspina, J. Vasquez, E. T. Donoghue, C. W. Hallahan, S. Liu, L. A. Ehler, M. A. Planta, S. Kottilil, et al.
Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals
PNAS,
May 13, 2003;
100(10):
6057 - 6062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Foussat, L. Bouchet-Delbos, D. Berrebi, I. Durand-Gasselin, A. Coulomb-L'Hermine, R. Krzysiek, P. Galanaud, Y. Levy, and D. Emilie
Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients
Blood,
September 15, 2001;
98(6):
1678 - 1686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Lindhout, J. L. M. Vissers, F. C. Hartgers, R. J. F. Huijbens, N. M. Scharenborg, C. G. Figdor, and G. J. Adema
The Dendritic Cell-Specific CC-Chemokine DC-CK1 Is Expressed by Germinal Center Dendritic Cells and Attracts CD38-Negative Mantle Zone B Lymphocytes
J. Immunol.,
March 1, 2001;
166(5):
3284 - 3289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Jones, R. J. Benjamin, A. Shahsafaei, and D. M. Dorfman
The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia
Blood,
January 15, 2000;
95(2):
627 - 632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Ansel, L. J. McHeyzer-Williams, V. N. Ngo, M. G. McHeyzer-Williams, and J. G. Cyster
In Vivo-activated CD4 T Cells Upregulate CXC Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines
J. Exp. Med.,
October 18, 1999;
190(8):
1123 - 1134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
