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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, C. H. Articles by Broxmeyer, H. E. Search for Related Content PubMed PubMed Citation Articles by Kim, C. H. Articles by Broxmeyer, H. E. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell-Derived Factor-1, Steel Factor, and the Bone Marrow Environment Chang H. Kim and Hal E. Broxmeyer From the Departments of Microbiology/Immunology, Medicine and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis; and the Walther Cancer Institute, Indianapolis, IN. How multiple chemoattractants cooperate in directing the migration of hematopoietic progenitor cells (HPC) for homing and peripheral blood mobilization has not yet been established. We report here the behavior of HPC under the influence of two different chemoattractants, stromal cell-derived factor (SDF)-1 and steel factor (SLF), and the chemotactic nature of the bone marrow (BM) environment using a two-chamber in vitro migration system. Various formulae were adopted to quantitate these effects. Based on these quantitations, SDF-1 showed only chemotactic activity, while SLF showed both chemotactic and chemokinetic activities on factor-dependent MO7e cells. SLF, like SDF-1, attracted human HPC from a population of CD34+ cells and induced actin polymerization in MO7e cells. SLF and SDF-1 cooperated in attracting MO7e cells, as well as cord blood (CB) and BM CD34+ cells. A negative concentration gradient of SLF and SDF-1, formed by the presence of chemoattractants in the upper chamber, showed potent inhibitory effects on MO7e cell migration induced by either of these chemoattractants in the lower chamber, and SDF-1 and SLF were synergistic in mobilizing cells to the lower chamber from this negative chemoattractant gradient. Plasma obtained from BM aspirates, but not CB or peripheral blood, showed strong chemotactic effects on BM and CB CD34+ cells, and an inhibitory effect in a negative gradient on SDF-1-dependent CD34+ cell migration. These in vitro migration experiments suggest that chemoattractants such as SDF-1 and SLF with other unidentified BM chemoattractants may be involved cooperatively in the migration of HPC to the BM and in preventing spontaneous mobilization of HPC out of the BM. Blood, Vol. 91 No. 1 (January 1), 1998: pp. 100-110 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. K. Kim, H.-N. Pak, J. H. Park, K. J. Ko, J. S. Lee, J. I. Choi, D. H. Choi, and Y.-H. Kim Clinical and serological predictors for the recurrence of atrial fibrillation after electrical cardioversion Europace, December 1, 2009; 11(12): 1632 - 1638. [Abstract] [Full Text] [PDF] S. K. Kim, H.-N. Pak, J. H. Park, J. I. Choi, M.-H. Nam, Y. Jo, and Y.-H. Kim Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1{alpha} mechanism Europace, August 1, 2009; 11(8): 1024 - 1031. [Abstract] [Full Text] [PDF] J. Grassinger, D. N. Haylock, M. J. Storan, G. O. Haines, B. Williams, G. A. Whitty, A. R. Vinson, C. L. Be, S. Li, E. S. 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Maurer Macrophage Inflammatory Protein 3{alpha} Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells J. Exp. Med., December 20, 1999; 190(12): 1755 - 1768. [Abstract] [Full Text] [PDF] A. J. Naiyer, D.-Y. Jo, J. Ahn, R. Mohle, M. Peichev, G. Lam, R. L. Silverstein, M. A.S. Moore, and S. Rafii Stromal Derived Factor-1-Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin Blood, December 15, 1999; 94(12): 4011 - 4019. [Abstract] [Full Text] [PDF] R. Salgia, E. Quackenbush, J. Lin, N. Souchkova, M. Sattler, D. S. Ewaniuk, K. M. Klucher, G. Q. Daley, S. K. Kraeft, R. Sackstein, et al. The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1alpha Blood, December 15, 1999; 94(12): 4233 - 4246. [Abstract] [Full Text] [PDF] M. Honczarenko, R. S. Douglas, C. Mathias, B. Lee, M. Z. Ratajczak, and L. E. 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Nagasawa A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution PNAS, May 11, 1999; 96(10): 5663 - 5667. [Abstract] [Full Text] [PDF] S. Reid, A. Ritchie, L. Boring, J. Gosling, S. Cooper, G. Hangoc, I. F. Charo, and H. E. Broxmeyer Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2 Blood, March 1, 1999; 93(5): 1524 - 1533. [Abstract] [Full Text] [PDF] A. Peled, I. Petit, O. Kollet, M. Magid, T. Ponomaryov, T. Byk, A. Nagler, H. Ben-Hur, A. Many, L. Shultz, et al. Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 Science, February 5, 1999; 283(5403): 845 - 848. [Abstract] [Full Text] S. W. Cole, B. D. Jamieson, and J. A. Zack cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection J. Immunol., February 1, 1999; 162(3): 1392 - 1400. [Abstract] [Full Text] [PDF] D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF] P. Dutt, J.-F. Wang, and J. E. Groopman Stromal Cell-Derived Factor-1{alpha} and Stem Cell Factor/kit Ligand Share Signaling Pathways in Hemopoietic Progenitors: A Potential Mechanism for Cooperative Induction of Chemotaxis J. Immunol., October 1, 1998; 161(7): 3652 - 3658. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, and H. E. Broxmeyer Macrophage-Inflammatory Protein-3{beta}/EBI1-Ligand Chemokine/CK{beta}-11, a CC Chemokine, Is a Chemoattractant with a Specificity for Macrophage Progenitors Among Myeloid Progenitor Cells J. Immunol., September 1, 1998; 161(5): 2580 - 2585. [Abstract] [Full Text] [PDF] T. Hamada, R. Mohle, J. Hesselgesser, J. Hoxie, R. L. Nachman, M. A.S. Moore, and S. Rafii Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation J. Exp. Med., August 3, 1998; 188(3): 539 - 548. [Abstract] [Full Text] [PDF] J.-F. Wang, Z.-Y. Liu, and J. E. Groopman The alpha -Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion Blood, August 1, 1998; 92(3): 756 - 764. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, and H. E. Broxmeyer Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines Blood, June 15, 1998; 91(12): 4434 - 4443. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, E. Applebaum, K. Johanson, and H. E. Broxmeyer CK{beta}-11/Macrophage Inflammatory Protein-3{beta}/EBI1-Ligand Chemokine Is an Efficacious Chemoattractant for T and B Cells J. Immunol., March 1, 1998; 160(5): 2418 - 2424. [Abstract] [Full Text] [PDF]

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