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Molecular Delineation of 13q Deletion Boundaries in 20 Patients
With Myeloid Malignancies
R. La Starza,
I. Wlodarska,
A. Aventin,
D. Falzetti,
B. Crescenzi,
M.F. Martelli,
H. Van den Berghe, and
C. Mecucci
From the Hematology Unit, University of Perugia, Perugia, Italy;
Center for Human Genetics and Flanders Interuniversity Institute of
Biotechnology, University of Leuven, Leuven, Belgium; and the
Department of Hematology, University Hospital San Pau, Barcelona,
Spain.
Fluorescent in situ hybridization (FISH) analysis with
a panel of DNA probes for 13q13.1-q14.3 was performed on 20 cases of myeloid malignancies, of which 17 showed a del(13)(q) and three had
translocations affecting 13q. By chromosome morphology, deletions consistently involved bands q14 and q21. In addition to confirming the
chromosome data, FISH allowed us to delineate a commonly deleted region
that was flanked by YAC 833A2 and YAC 854D4. Three cases with 13q
translocations unexpectedly showed accompanying cryptic microdeletions
of 13q, and in one case the commonly deleted region could be narrowed
to a genomic segment, which includes YAC 937C7, RB1, and YAC 745E3.
Homozygous deletions were not detected. This region overlaps with the
smallest deleted region of 13q14 in chronic lymphocytic leukemia.
Blood, Vol. 91 No. 1 (January 1), 1998:
pp. 231-237
© 1998 by The American Society of Hematology.
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