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Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral
Blood Mononuclear Cells and in the U937 Cell Line
Priscilla Biswas,
Fanny Delfanti,
Sergio Bernasconi,
Manuela Mengozzi,
Manuela Cota,
Nadia Polentarutti,
Alberto Mantovani,
Adriano Lazzarin,
Silvano Sozzani, and
Guido Poli
From the AIDS Immunopathogenesis Unit, DIBIT, and the Division of
Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy;
the Department of Immunology and Cell Biology, "Mario Negri"
Institute for Pharmacological Research, Milan, Italy; and the
Department of Pathology, University of Brescia, Brescia, Italy.
Induction of chemokine gene expression from peripheral blood
mononuclear cells (PBMCs) stimulated by proinflammatory cytokines plays
an important role in both wound repair and response to infectious agents. In the present study, we show that the proinflammatory cytokine
interleukin-6 (IL-6) potently induced mRNA expression and secretion of
the CC chemokine monocyte chemotactic protein 1 (MCP-1) in PBMCs. In
addition, because human immunodeficiency virus (HIV) infection in vivo
and in vitro has been shown to dysregulate the production of
and/or the response to cytokines, PBMCs from both healthy
uninfected and HIV-infected individuals were studied for their
constitutive and IL-6-induced expression of MCP-1. No substantial
differences were observed between the two groups of individuals. In
addition, IL-6 upregulated MCP-1 expression in the promonocytic cell
line U937 and in its chronically HIV-infected counterpart, U1. In these
cell lines, IL-6 selectively induced MCP-1 and not other chemokines,
including regulated upon activation normal T cells expressed and
secreted (RANTES), macrophage inflammatory protein-1 (MIP-1),
MIP-1 , and IL-8. IL-6 induction of MCP-1 was partially inhibited by
hydrocortisone in U1 cells. Thus, IL-6 activates PBMCs to secrete
MCP-1, a CC chemokine pivotal for monocyte recruitment in tissue and
organs in which important inflammatory events occur.
Blood, Vol. 91 No. 1 (January 1), 1998:
pp. 258-265
© 1998 by The American Society of Hematology.
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