|
|
 Previous Article | Table of Contents | Next Article 
Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral
Blood Mononuclear Cells and in the U937 Cell Line
Priscilla Biswas,
Fanny Delfanti,
Sergio Bernasconi,
Manuela Mengozzi,
Manuela Cota,
Nadia Polentarutti,
Alberto Mantovani,
Adriano Lazzarin,
Silvano Sozzani, and
Guido Poli
From the AIDS Immunopathogenesis Unit, DIBIT, and the Division of
Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy;
the Department of Immunology and Cell Biology, "Mario Negri"
Institute for Pharmacological Research, Milan, Italy; and the
Department of Pathology, University of Brescia, Brescia, Italy.
Induction of chemokine gene expression from peripheral blood
mononuclear cells (PBMCs) stimulated by proinflammatory cytokines plays
an important role in both wound repair and response to infectious agents. In the present study, we show that the proinflammatory cytokine
interleukin-6 (IL-6) potently induced mRNA expression and secretion of
the CC chemokine monocyte chemotactic protein 1 (MCP-1) in PBMCs. In
addition, because human immunodeficiency virus (HIV) infection in vivo
and in vitro has been shown to dysregulate the production of
and/or the response to cytokines, PBMCs from both healthy
uninfected and HIV-infected individuals were studied for their
constitutive and IL-6-induced expression of MCP-1. No substantial
differences were observed between the two groups of individuals. In
addition, IL-6 upregulated MCP-1 expression in the promonocytic cell
line U937 and in its chronically HIV-infected counterpart, U1. In these
cell lines, IL-6 selectively induced MCP-1 and not other chemokines,
including regulated upon activation normal T cells expressed and
secreted (RANTES), macrophage inflammatory protein-1 (MIP-1),
MIP-1 , and IL-8. IL-6 induction of MCP-1 was partially inhibited by
hydrocortisone in U1 cells. Thus, IL-6 activates PBMCs to secrete
MCP-1, a CC chemokine pivotal for monocyte recruitment in tissue and
organs in which important inflammatory events occur.
Blood, Vol. 91 No. 1 (January 1), 1998:
pp. 258-265
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. Chen, A. Frister, S. Wang, A. Ludwig, H. Behr, S. Pippig, B. Li, A. Simm, B. Hofmann, C. Pilowski, et al.
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production
Am J Physiol Heart Circ Physiol,
April 1, 2009;
296(4):
H987 - H996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ray, C. Lee, T. Hou, I. Boldogh, and A. R. Brasier
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
Nucleic Acids Res.,
August 1, 2008;
36(13):
4510 - 4520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Stern and B. Slobedman
Human Cytomegalovirus Latent Infection of Myeloid Cells Directs Monocyte Migration by Up-Regulating Monocyte Chemotactic Protein-1
J. Immunol.,
May 15, 2008;
180(10):
6577 - 6585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tanimoto, Y. Murata, K.-Y. Wang, M. Tsutsui, K. Kohno, and Y. Sasaguri
Monocyte Chemoattractant Protein-1 Expression Is Enhanced by Granulocyte-Macrophage Colony-stimulating Factor via Jak2-Stat5 Signaling and Inhibited by Atorvastatin in Human Monocytic U937 Cells
J. Biol. Chem.,
February 22, 2008;
283(8):
4643 - 4651.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nomura, K. Ishii, Y. Kamitsuji, N. Uoshima, E. Ishikawa, H. Kitayama, and K. Hayashi
Elevation of Activated Platelet-Dependent Chemokines in Patients With Anti-CD20 Monoclonal Antibody (Rituximab)-Treated Non-Hodgkin's Lymphoma
Clinical and Applied Thrombosis/Hemostasis,
April 1, 2007;
13(2):
206 - 212.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Jewett, C. Head, and N.A. Cacalano
Emerging Mechanisms of Immunosuppression in Oral Cancers
Journal of Dental Research,
December 1, 2006;
85(12):
1061 - 1073.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Rowland, G. Lertmemongkolchai, A. Bancroft, A. Haque, M. S. Lever, K. F. Griffin, M. C. Jackson, M. Nelson, A. O'Garra, R. Grencis, et al.
Critical Role of Type 1 Cytokines in Controlling Initial Infection with Burkholderia mallei
Infect. Immun.,
September 1, 2006;
74(9):
5333 - 5340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Rizzi, M. P. Crippa, R. E. Jeeninga, B. Berkhout, F. Blasi, G. Poli, and M. Alfano
Pertussis Toxin B-Oligomer Suppresses IL-6 Induced HIV-1 and Chemokine Expression in Chronically Infected U1 Cells via Inhibition of Activator Protein 1
J. Immunol.,
January 15, 2006;
176(2):
999 - 1006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Caselli, M. Galvan, E. Cassai, A. Caruso, L. Sighinolfi, and D. Di Luca
Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells
Blood,
October 15, 2005;
106(8):
2790 - 2797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Martinez, Y. Juarranz, C. Abad, A. Arranz, B. G. Miguel, F. Rosignoli, J. Leceta, and R. P. Gomariz
Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock
J. Leukoc. Biol.,
May 1, 2005;
77(5):
729 - 738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. A. Patel, P. K. Chatterjee, R. Di Paola, E. Mazzon, D. Britti, A. De Sarro, S. Cuzzocrea, and C. Thiemermann
Endogenous Interleukin-6 Enhances the Renal Injury, Dysfunction, and Inflammation Caused by Ischemia/Reperfusion
J. Pharmacol. Exp. Ther.,
March 1, 2005;
312(3):
1170 - 1178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Yamagami, K. Kitagawa, Y. Nagai, H. Hougaku, M. Sakaguchi, K. Kuwabara, K. Kondo, T. Masuyama, M. Matsumoto, and M. Hori
Higher Levels of Interleukin-6 Are Associated With Lower Echogenicity of Carotid Artery Plaques
Stroke,
March 1, 2004;
35(3):
677 - 681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Penido, A. Vieira-de-Abreu, M. T. Bozza, H. C. Castro-Faria-Neto, and P. T. Bozza
Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on {gamma}{delta} T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guerin
J. Immunol.,
December 15, 2003;
171(12):
6788 - 6794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Di Napoli and F. Papa
Association Between Blood Pressure and C-Reactive Protein Levels in Acute Ischemic Stroke
Hypertension,
December 1, 2003;
42(6):
1117 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Fantuzzi, F. Belardelli, and S. Gessani
Monocyte/macrophage-derived CC chemokines and their modulation by HIV-1 and cytokines: A complex network of interactions influencing viral replication and AIDS pathogenesis
J. Leukoc. Biol.,
November 1, 2003;
74(5):
719 - 725.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-S. Cho, M.-L. Cho, P. P. Chen, S.-Y. Min, S.-Y. Hwang, K.-S. Park, W.-U. Kim, D.-J. Min, J.-K. Min, S.-H. Park, et al.
Antiphospholipid Antibodies Induce Monocyte Chemoattractant Protein-1 in Endothelial Cells
J. Immunol.,
April 15, 2002;
168(8):
4209 - 4215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. U. Chae, R. T. Lee, N. Rifai, and P. M. Ridker
Blood Pressure and Inflammation in Apparently Healthy Men
Hypertension,
September 1, 2001;
38(3):
399 - 403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Arepally and I. M. Mayer
Antibodies from patients with heparin-induced thrombocytopenia stimulate monocytic cells to express tissue factor and secrete interleukin-8
Blood,
August 15, 2001;
98(4):
1252 - 1254.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Guleria and J. W. Pollard
Aberrant Macrophage and Neutrophil Population Dynamics and Impaired Th1 Response to Listeria monocytogenes in Colony-Stimulating Factor 1-Deficient Mice
Infect. Immun.,
March 1, 2001;
69(3):
1795 - 1807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ito, U. Ikeda, M. Shimpo, K. Yamamoto, and K. Shimada
Serotonin Increases Interleukin-6 Synthesis in Human Vascular Smooth Muscle Cells
Circulation,
November 14, 2000;
102(20):
2522 - 2527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister
Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production
J. Immunol.,
August 15, 2000;
165(4):
1939 - 1948.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Aubry, C. Habasque, A.-P. Satie, B. Jégou, and M. Samson
Expression and Regulation of the CC-Chemokine Monocyte Chemoattractant Protein-1 in Rat Testicular Cells in Primary Culture
Biol Reprod,
May 1, 2000;
62(5):
1427 - 1435.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Schieffer, E. Schieffer, D. Hilfiker-Kleiner, A. Hilfiker, P. T. Kovanen, M. Kaartinen, J. Nussberger, W. Harringer, and H. Drexler
Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques : Potential Implications for Inflammation and Plaque Instability
Circulation,
March 28, 2000;
101(12):
1372 - 1378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Delerive, K. De Bosscher, S. Besnard, W. Vanden Berghe, J. M. Peters, F. J. Gonzalez, J.-C. Fruchart, A. Tedgui, G. Haegeman, and B. Staels
Peroxisome Proliferator-activated Receptor alpha Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-kappa B and AP-1
J. Biol. Chem.,
November 5, 1999;
274(45):
32048 - 32054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. S. Leal, B. Smedegard, P. Andersen, and R. Appelberg
Interleukin-6 and Interleukin-12 Participate in Induction of a Type 1 Protective T-Cell Response during Vaccination with a Tuberculosis Subunit Vaccine
Infect. Immun.,
November 1, 1999;
67(11):
5747 - 5754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Vlahopoulos, I. Boldogh, A. Casola, and A. R. Brasier
Nuclear Factor-kappa B-Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor alpha : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation
Blood,
September 15, 1999;
94(6):
1878 - 1889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Sporri, K. M. Muller, U. Wiesmann, and M. Bickel
Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts
Int. Immunol.,
July 1, 1999;
11(7):
1053 - 1058.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aiuti, L. Turchetto, M. Cota, A. Cipponi, A. Brambilla, C. Arcelloni, R. Paroni, E. Vicenzi, C. Bordignon, and G. Poli
Human CD34+ Cells Express CXCR4 and Its Ligand Stromal Cell-Derived Factor-1. Implications for Infection by T-Cell Tropic Human Immunodeficiency Virus
Blood,
July 1, 1999;
94(1):
62 - 73.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mengozzi, C. De Filippi, P. Transidico, P. Biswas, M. Cota, S. Ghezzi, E. Vicenzi, A. Mantovani, S. Sozzani, and G. Poli
Human Immunodeficiency Virus Replication Induces Monocyte Chemotactic Protein-1 in Human Macrophages and U937 Promonocytic Cells
Blood,
March 15, 1999;
93(6):
1851 - 1857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-W. Oh, N. J. Van Wagoner, S. Rose-John, and E. N. Benveniste
Role of IL-6 and the Soluble IL-6 Receptor in Inhibition of VCAM-1 Gene Expression
J. Immunol.,
November 1, 1998;
161(9):
4992 - 4999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Sukovich, K. Kauser, F. D. Shirley, V. DelVecchio, M. Halks-Miller, and G. M. Rubanyi
Expression of Interleukin-6 in Atherosclerotic Lesions of Male ApoE-Knockout Mice : Inhibition by 17ß-Estradiol
Arterioscler. Thromb. Vasc. Biol.,
September 1, 1998;
18(9):
1498 - 1505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
