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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ohene-Frempong, K. Articles by Sickle Cell Disease, t. C. S. o. Search for Related Content PubMed PubMed Citation Articles by Ohene-Frempong, K. Articles by Sickle Cell Disease, t. C. S. o. Related Collections Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Cerebrovascular Accidents in Sickle Cell Disease: Rates and Risk Factors Kwaku Ohene-Frempong, Steven J. Weiner, Lynn A. Sleeper, Scott T. Miller, Stephen Embury, John W. Moohr, Doris L. Wethers, Charles H. Pegelow, Frances M. Gill, and the Cooperative Study of Sickle Cell Disease From The University of Pennsylvania School of Medicine and the Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA; the New England Research Institutes, Watertown, MA; the Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, NY; the San Francisco General Hospital and the University of California, San Francisco, San Francisco, CA; the Department of Pediatrics, Woodhull Medical and Mental Health Center, Brooklyn, NY; the Department of Pediatrics, Columbia University School of Medicine and St Luke's/Roosevelt Hospital, New York, NY; the Department of Pediatrics, University of Miami, Miami, FL; and the Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA. Cerebrovascular accident (CVA) is a major complication of sickle cell disease. The incidence and mortality of and risk factors for CVA in sickle cell disease patients in the United States have been reported only in small patient samples. The Cooperative Study of Sickle Cell Disease collected clinical data on 4,082 sickle cell disease patients enrolled from 1978 to 1988. Patients were followed for an average of 5.2 ± 2.0 years. Age-specific prevalence and incidence rates of CVA in patients with the common genotypes of sickle cell disease were determined, and the effects of hematologic and clinical events on the risk of CVA were analyzed. The highest rates of prevalence of CVA (4.01%) and incidence (0.61 per 100 patient-years) were in sickle cell anemia (SS) patients, but CVA occurred in all common genotypes. The incidence of infarctive CVA was lowest in SS patients 20 to 29 years of age and higher in children and older patients. Conversely, the incidence of hemorrhagic stroke in SS patients was highest among patients aged 20 to 29 years. Across all ages the mortality rate was 26% in the 2 weeks after hemorrhagic stroke. No deaths occurred after infarctive stroke. Risk factors for infarctive stroke included prior transient ischemic attack, low steady-state hemoglobin concentration and rate of and recent episode of acute chest syndrome, and elevated systolic blood pressure. Hemorrhagic stroke was associated with low steady-state hemoglobin and high leukocyte count. Blood, Vol. 91 No. 1 (January 1), 1998: pp. 288-294 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. B. Bailey Jr, F. D. Armstrong, A. R. Kemper, D. Skinner, and S. F. Warren Supporting Family Adaptation to Presymptomatic and "Untreatable" Conditions in an Era of Expanded Newborn Screening J. Pediatr. Psychol., July 1, 2009; 34(6): 648 - 661. [Abstract] [Full Text] [PDF] G. R. Kirk, M. R. Haynes, S. Palasis, C. Brown, T. G. 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