|
|
 Previous Article | Table of Contents | Next Article 
Impaired Induction of the CD28-Responsive Complex in
Granulocyte Colony-Stimulating Factor Mobilized CD4 T Cells
Junji Tanaka,
Marco Mielcarek, and
Beverly Torok-Storb
From the Clinical Research Division, Fred Hutchinson Cancer Research
Center, Seattle, WA and the Department of Medicine, University of
Washington, Seattle, WA.
Use of the CD28/B7 costimulatory signal for T-cell activation was
analyzed in granulocyte colony-stimulating factor (G-CSF) mobilized
peripheral blood mononuclear cells (G-PBMCs) and in peripheral blood
mononuclear cells obtained before administration of G-CSF (preG-PBMCs).
CTLA4Ig inhibition of OKT3-stimulated proliferation was significantly
lower in G-PBMCs compared with preG-PBMCs (39.9% ± 5.6% and 72.2% ± 5.4%, respectively; P < .001). Furthermore, as shown in
electrophoretic mobility-shift assays, the inducible level of the
T-cell transcription factor CD28 responsive complex (CD28RC) was
suppressed in CD4 cells derived from G-PBMC. However, depletion of CD14
cells from G-PBMCs restored CD28RC induction to normal levels. Taken
together, these findings suggest that the large number of CD14
monocytes in G-PBMCs may limit T-cell responsiveness by suppressing the
induction of the CD28RC.
Blood, Vol. 91 No. 1 (January 1), 1998:
pp. 347-352
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. S. Morris, K. P. A. MacDonald, and G. R. Hill
Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?
Blood,
May 1, 2006;
107(9):
3430 - 3435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Rutella, F. Zavala, S. Danese, H. Kared, and G. Leone
Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance
J. Immunol.,
December 1, 2005;
175(11):
7085 - 7091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Crough, M. Nieda, and A. J. Nicol
Granulocyte Colony-Stimulating Factor Modulates {alpha}-Galactosylceramide-Responsive Human V{alpha}24+V{beta}11+ NKT Cells
J. Immunol.,
October 15, 2004;
173(8):
4960 - 4966.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tanaka, T. Toubai, Y. Tsutsumi, Y. Miura, N. Kato, S. Umehara, K. Kahata, A. Mori, N. Toyoshima, S. Ota, et al.
Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells
Blood,
August 1, 2004;
104(3):
768 - 774.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, V. K. Woodward, J. M. Shelton, J. A. Richardson, X. J. Zhou, D. Link, M. L. Kielar, D. R. Jeyarajah, and C. Y. Lu
Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro
Am J Physiol Renal Physiol,
June 1, 2004;
286(6):
F1193 - F1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Rutella, L. Pierelli, G. Bonanno, S. Sica, F. Ameglio, E. Capoluongo, A. Mariotti, G. Scambia, G. d'Onofrio, and G. Leone
Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells
Blood,
September 18, 2002;
100(7):
2562 - 2571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Tzachanis, A. Berezovskaya, L. M. Nadler, and V. A. Boussiotis
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses
Blood,
February 15, 2002;
99(4):
1465 - 1473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Zaucha, T. Gooley, W. I. Bensinger, S. Heimfeld, T. R. Chauncey, R. Zaucha, P. J. Martin, M. E. D. Flowers, J. Storek, G. Georges, et al.
CD34 cell dose in granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen-identical sibling transplantation
Blood,
December 1, 2001;
98(12):
3221 - 3227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Joshi, J. C. Lynch, S. Z. Pavletic, S. R. Tarantolo, S. J. Pirruccello, A. Kessinger, and M. R. Bishop
Decreased immune functions of blood cells following mobilization with granulocyte colony-stimulating factor: association with donor characteristics
Blood,
September 15, 2001;
98(6):
1963 - 1970.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Przepiorka, T. L. Smith, J. Folloder, I. Khouri, N. T. Ueno, R. Mehra, M. Korbling, Y. O. Huh, S. Giralt, J. Gajewski, et al.
Risk Factors for Acute Graft-Versus-Host Disease After Allogeneic Blood Stem Cell Transplantation
Blood,
August 15, 1999;
94(4):
1465 - 1470.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Singh, M. L. Varney, S. Buyukberber, K. Ino, A. G. Ageitos, E. Reed, S. Tarantolo, and J. E. Talmadge
Fas-FasL-mediated CD4+ T-Cell Apoptosis following Stem Cell Transplantation
Cancer Res.,
July 1, 1999;
59(13):
3107 - 3111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mielcarek, L. Graf, G. Johnson, and B. Torok-Storb
Production of Interleukin-10 by Granulocyte Colony-Stimulating Factor-Mobilized Blood Products: A Mechanism for Monocyte-Mediated Suppression of T-Cell Proliferation
Blood,
July 1, 1998;
92(1):
215 - 222.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
